Selective Cytotoxicity of Medical Cannabis (Cannabis sativa L.) Extracts Across the Whole Vegetation Cycle Under Various Hydroponic and Nutritional Treatments
Cannabis Cannabinoid Res. 2022 Dec 1. doi: 10.1089/can.2022.0243. Online ahead of print. ABSTRACT Introduction: The use of Cannabis sativa L. in health care requires stringent...
Cold Ethanol Extraction of Cannabinoids and Terpenes from Cannabis Using Response Surface Methodology: Optimization and Comparative Study
Molecules. 2022 Dec 11;27(24):8780. doi: 10.3390/molecules27248780. ABSTRACT Efficient cannabis biomass extraction can increase yield while reducing costs and minimizing waste. Cold ethanol extraction was evaluated...
Microwave- and Ultrasound-Assisted Extraction of Cannabinoids and Terpenes from Cannabis Using Response Surface Methodology
Molecules. 2022 Dec 12;27(24):8803. doi: 10.3390/molecules27248803. ABSTRACT Limited studies have explored different extraction techniques that improve cannabis extraction with scale-up potential. Ultrasound-assisted and microwave-assisted extraction...
Molecular Modeling Targeting the ACE2 Receptor with Cannabis sativa‘s Active Ingredients for Antiviral Drug Discovery against SARS-CoV-2 Infections
Bioinform Biol Insights. 2022 Dec 22;16:11779322221145380. doi: 10.1177/11779322221145380. eCollection 2022. ABSTRACT The emergence of a novel coronavirus that later on rendered a global pandemic, caused...
Novel fluorescence spectroscopy method coupled with N-PLS-R and PLS-DA models for the quantification of cannabinoids and the classification of cannabis cultivars
Phytochem Anal. 2023 Apr;34(3):280-288. doi: 10.1002/pca.3205. Epub 2023 Jan 4. ABSTRACT INTRODUCTION: Cannabis sativa L. inflorescences are rich in secondary metabolites, particularly cannabinoids. The most...
Exogenous application of stress-related signaling molecules affect growth and cannabinoid accumulation in medical cannabis (Cannabis sativa L.)
Front Plant Sci. 2022 Dec 20;13:1082554. doi: 10.3389/fpls.2022.1082554. eCollection 2022. ABSTRACT Medical cannabis (Cannabis sativa L.) is a source of bioactive phytochemicals with promising pharmacological...
The B1080/B1192 molecular marker identifies hemp plants with functional THCA synthase and total THC content above legal limit
Gene. 2023 Mar 30;858:147198. doi: 10.1016/j.gene.2023.147198. Epub 2023 Jan 11. ABSTRACT In Cannabis sativa L. the presence of delta 9-tetrahydrocannabinolic acid (THCA) above legal limit...
Evaluation of decarboxylation efficiency of Δ9-tetrahydrocannabinolic acid and cannabidiolic acid by UNODC method
Forensic Toxicol. 2023 Jan;41(1):105-113. doi: 10.1007/s11419-022-00645-7. Epub 2022 Sep 23. ABSTRACT PURPOSE: Decarboxylation of Δ9-tetrahydrocannabinolic acid (Δ9-THCA) to Δ9-tetrahydrocannabinol (Δ9-THC) by heating is a common...
Twice-daily oral administration of a cannabidiol and cannabidiolic acid-rich hemp extract was well tolerated in orange-winged Amazon parrots (Amazona amazonica) and has a favorable pharmacokinetic profile
Am J Vet Res. 2023 Feb 21;84(4):ajvr.22.11.0197. doi: 10.2460/ajvr.22.11.0197. Print 2023 Apr 1. ABSTRACT OBJECTIVE: To determine the pharmacokinetics of 8 cannabinoids and 5 metabolites...
Biotechnological Fungal Platforms for the Production of Biosynthetic Cannabinoids
J Fungi (Basel). 2023 Feb 10;9(2):234. doi: 10.3390/jof9020234. ABSTRACT Cannabinoids are bioactive meroterpenoids comprising prenylated polyketide molecules that can modulate a wide range of physiological...
Excretion and residue depletion of cannabinoids in beef cattle fed hempseed cake for 111 days
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2023 Apr;40(4):552-565. doi: 10.1080/19440049.2023.2187645. Epub 2023 Mar 10. ABSTRACT Thirty-two crossbred heifers were fed...
Comparative metabolism of THCA and THCV using UHPLC-Q-Exactive Orbitrap-MS
Xenobiotica. 2023 Jan;53(1):46-59. doi: 10.1080/00498254.2023.2194981. Epub 2023 Apr 10. ABSTRACT Delta(9)-tetrahydrocannabinolic acid (THCA) and delta(9)-tetrahydrocannabivarin (THCV) are phytocannabinoids with a similar structure derived from Cannabis...
Enantioseparation of chiral phytocannabinoids in medicinal cannabis
J Chromatogr B Analyt Technol Biomed Life Sci. 2023 Apr 15;1221:123682. doi: 10.1016/j.jchromb.2023.123682. Epub 2023 Mar 21. ABSTRACT The evaluation of the chiral composition of...
Beyond cannabinoids: Application of NMR-based metabolomics for the assessment of Cannabis sativa L. crop health
Front Plant Sci. 2023 Mar 22;14:1025932. doi: 10.3389/fpls.2023.1025932. eCollection 2023. ABSTRACT While Cannabis sativa L. varieties have been traditionally characterized by their major cannabinoid profile,...
The Cannabinoids, CBDA and THCA, Rescue Memory Deficits and Reduce Amyloid-Beta and Tau Pathology in an Alzheimer’s Disease-like Mouse Model
Int J Mol Sci. 2023 Apr 6;24(7):6827. doi: 10.3390/ijms24076827. ABSTRACT Most studies related to hemp are focused on Cannabidiol (CBD) and Tetrahydrocannabinol (THC); however, up...