Associations between polygenic risk of substance use and use disorder and alcohol, cannabis, and nicotine use in adolescence and young adulthood in a longitudinal twin study
Psychol Med. 2023 Apr;53(6):2296-2306. doi: 10.1017/S0033291721004116. Epub 2021 Oct 12. ABSTRACT BACKGROUND: Recent well-powered genome-wide association studies have enhanced prediction of substance use outcomes via...
Continuities in maternal substance use from early adolescence to parenthood: findings from the intergenerational cohort consortium
Psychol Med. 2023 Apr;53(5):2136-2145. doi: 10.1017/S0033291721003925. Epub 2021 Oct 8. ABSTRACT BACKGROUND: This study assessed the extent to which women’s preconception binge drinking, tobacco use...
Disentangling heterogeneity of psychosis expression in the general population: sex-specific moderation effects of environmental risk factors on symptom networks
Psychol Med. 2023 Apr;53(5):1860-1869. doi: 10.1017/S0033291721003470. Epub 2021 Aug 25. ABSTRACT BACKGROUND: Psychosis expression in the general population may reflect a behavioral manifestation of the...
Independent contribution of polygenic risk for schizophrenia and cannabis use in predicting psychotic-like experiences in young adulthood: testing gene × environment moderation and mediation
Psychol Med. 2023 Apr;53(5):1759-1769. doi: 10.1017/S0033291721003378. Epub 2021 Sep 23. ABSTRACT BACKGROUND: It has not yet been determined if the commonly reported cannabis-psychosis association is...
Preclinical effects of cannabidiol in an experimental model of migraine
Pain. 2023 Jun 9. doi: 10.1097/j.pain.0000000000002960. Online ahead of print. ABSTRACT Migraine is a disabling disorder characterized by recurrent headaches, accompanied by abnormal sensory sensitivity...
Development, Characterization and Evidence of Anti-Endometriotic Activity of Phytocannabinoid-Rich Nanoemulsions
Int J Pharm. 2023 May 15:123049. doi: 10.1016/j.ijpharm.2023.123049. Online ahead of print. ABSTRACT During the last decades, the cannabinoid research for therapeutic purposes has been...
Bioactivity of the cannabigerol cannabinoid and its analogues – the role of 3-dimensional conformation
Org Biomol Chem. 2023 Jun 7;21(22):4683-4693. doi: 10.1039/d3ob00383c. ABSTRACT Cannabinoids are naturally occurring bioactive compounds with the potential to help treat chronic illnesses including epilepsy,...
Editorial: Cannabinoid interactions with ion channels, receptors, and the bio-membrane
Front Physiol. 2023 May 9;14:1211230. doi: 10.3389/fphys.2023.1211230. eCollection 2023. NO ABSTRACT PMID:37228821 | PMC:PMC10203607 | DOI:10.3389/fphys.2023.1211230...
Role of omega-3 and omega-6 endocannabinoids in cardiopulmonary pharmacology
Adv Pharmacol. 2023;97:375-422. doi: 10.1016/bs.apha.2023.02.003. Epub 2023 Mar 28. ABSTRACT Endocannabinoids are derived from dietary omega-3 and omega-6 fatty acids and play an important role...
Isolation of Biologically Active Compounds from Cannabis sativa L. Inflorescences by Using Different Extraction Solvents and Evaluation of Antimicrobial Activity
Antioxidants (Basel). 2023 Apr 25;12(5):998. doi: 10.3390/antiox12050998. ABSTRACT Hemp inflorescences are a source of vital compounds, including phytocannabinoids and other biologically active compounds. Various methods...
Non-Psychoactive Cannabinoid Modulation of Nociception and Inflammation Associated with a Rat Model of Pulpitis
Biomolecules. 2023 May 16;13(5):846. doi: 10.3390/biom13050846. ABSTRACT Despite advancements in dental pain management, one of the most common reasons for emergency dental care is orofacial...
Cannabinoid and Opioid Receptor Affinity and Modulation of Cancer-Related Signaling Pathways of Machaeriols and Machaeridiols from Machaerium Pers
Molecules. 2023 May 18;28(10):4162. doi: 10.3390/molecules28104162. ABSTRACT Machaeriols and machaeridiols are unique hexahydrodibenzopyran-type aralkyl phytocannabinoids isolated from Machaerium Pers. Earlier studies of machaeriol A (1)...
Cannabidiol and Minor Phytocannabinoids: A Preliminary Study to Assess Their Anti-Melanoma, Anti-Melanogenic, and Anti-Tyrosinase Properties
Pharmaceuticals (Basel). 2023 Apr 26;16(5):648. doi: 10.3390/ph16050648. ABSTRACT Currently, there is an increased interest from both scientists and consumers in the application of cannabis/hemp/phytocannabinoids in...
Cell-autonomous and differential endocannabinoid signaling impacts the development of presynaptic retinal ganglion cell axon connectivity in vivo
Front Synaptic Neurosci. 2023 May 12;15:1176864. doi: 10.3389/fnsyn.2023.1176864. eCollection 2023. ABSTRACT Cannabis exposure during gestation evokes significant molecular modifications to neurodevelopmental programs leading to neurophysiological...
Anti-allodynic and medullary modulatory effects of a single dose of delta-9-tetrahydrocannabinol (THC) in neuropathic rats tolerant to morphine
Prog Neuropsychopharmacol Biol Psychiatry. 2023 May 29:110805. doi: 10.1016/j.pnpbp.2023.110805. Online ahead of print. ABSTRACT Neuropathic pain (NP) is often treated with opioids, the prolonged use...