Potential of dietary polyphenols for protection from age-related decline and neurodegeneration: a role for gut microbiota?
Nutr Neurosci. 2024 Jan 29:1-19. doi: 10.1080/1028415X.2023.2298098. Online ahead of print. ABSTRACT Many epidemiological studies have shown the beneficial effects of a largely plant-based diet,...
Potential of dietary polyphenols for protection from age-related decline and neurodegeneration: a role for gut microbiota?
Nutr Neurosci. 2024 Jan 29:1-19. doi: 10.1080/1028415X.2023.2298098. Online ahead of print. ABSTRACT Many epidemiological studies have shown the beneficial effects of a largely plant-based diet,...
Neuroprotective effect of isovaleraldehyde accompanied with upregulation of BDNF and CREB phosphorylation via the PKA pathway
J Nat Med. 2024 Jan;78(1):208-215. doi: 10.1007/s11418-023-01763-1. Epub 2023 Dec 8. ABSTRACT Recently, the number of patients diagnosed with dementia has increased. The World Health...
Short-term cocoa bioflavanol supplementation does not improve cold-induced vasodilation in young healthy adults
Eur J Appl Physiol. 2023 Dec 27. doi: 10.1007/s00421-023-05380-4. Online ahead of print. ABSTRACT PURPOSE: Cold-induced vasodilation (CIVD) is an oscillatory rise in blood flow...
Biological Properties and Antimicrobial Potential of Cocoa and Its Effects on Systemic and Oral Health
Nutrients. 2023 Sep 10;15(18):3927. doi: 10.3390/nu15183927. ABSTRACT Cocoa is considered a functional food because it is a natural source of macro- and micronutrients. Thus, cocoa...
A combined DHA-rich fish oil and cocoa flavanols intervention does not improve cognition or brain structure in older adults with memory complaints: results from the CANN randomized, controlled parallel-design study
Am J Clin Nutr. 2023 Aug;118(2):369-381. doi: 10.1016/j.ajcnut.2023.06.008. Epub 2023 Jun 12. ABSTRACT BACKGROUND: There is evidence that both omega-3 long-chain polyunsaturated fatty acids (PUFAs)...
Anti-Alzheimer Activity of Combinations of Cocoa with Vinpocetine or Other Nutraceuticals in Rat Model: Modulation of Wnt3/β-Catenin/GSK-3β/Nrf2/HO-1 and PERK/CHOP/Bcl-2 Pathways
Pharmaceutics. 2023 Jul 31;15(8):2063. doi: 10.3390/pharmaceutics15082063. ABSTRACT Alzheimer’s disease (AD) is a devastating illness with limited therapeutic interventions. The aim of this study is to...
The Influence of APOE Genotype, DHA, and Flavanol Intervention on Brain DHA and Lipidomics Profile in Aged Transgenic Mice
Nutrients. 2023 Apr 23;15(9):2032. doi: 10.3390/nu15092032. ABSTRACT The apolipoprotein E4 (APOE4) genotype is predictive of Alzheimer’s disease (AD). The brain is highly enriched with the...
A single dose of microencapsulated cocoa supplementation attenuated eccentric exercise-induced endothelial dysfunction
Int J Food Sci Nutr. 2023 May;74(3):373-381. doi: 10.1080/09637486.2023.2207783. Epub 2023 May 9. ABSTRACT In the present study, it was evaluated whether microencapsulated cocoa supplementation...
Cocoa flavanol supplementation preserves early and late radial artery function after transradial catheterization
Food Funct. 2023 May 22;14(10):4824-4835. doi: 10.1039/d3fo01116j. ABSTRACT Background: The transradial approach for coronary angiography is associated with fewer complications and preferred over the femoral...
Suppression of tomato wilt by cell-free supernatants of Acinetobacter baumannii isolates from wild cacao from the Colombian Amazon
World J Microbiol Biotechnol. 2023 Sep 2;39(11):297. doi: 10.1007/s11274-023-03719-9. ABSTRACT Tomato vascular wilt caused by Fusarium oxysporum f. sp. lycopersici (Fol) is one of the...
Cocoa flavanols improve peakVO2 and exercise capacity in a randomized double blinded clinical trial in healthy elderly people
Food Funct. 2023 Aug 14;14(16):7562-7573. doi: 10.1039/d3fo01737k. ABSTRACT Background: Loss of functional capacity is one of the hallmarks in cardiovascular aging. Cocoa flavanols (CF) exert...
Exploring the Nutritional Composition and Bioactive Compounds in Different Cocoa Powders
Antioxidants (Basel). 2023 Mar 14;12(3):716. doi: 10.3390/antiox12030716. ABSTRACT Cocoa, the main derivative of the seeds of Theobroma cacao L., has been recognized to have several...
Flavan-3-ol-methylxanthine interactions: Modulation of flavan-3-ol bioavailability in volunteers with a functional colon and an ileostomy
Free Radic Biol Med. 2023 Jan 5:S0891-5849(23)00004-7. doi: 10.1016/j.freeradbiomed.2023.01.003. Online ahead of print. ABSTRACT Flavan-3-ols, including the flavan-3-ol monomer (-)-epicatechin, are dietary bioactives known to...
Mental Performance and Sport: Caffeine and Co-consumed Bioactive Ingredients
Sports Med. 2022 Nov 30. doi: 10.1007/s40279-022-01796-8. Online ahead of print. ABSTRACT The plant defence compound caffeine is widely consumed as a performance enhancer in...