A combined DHA-rich fish oil and cocoa flavanols intervention does not improve cognition or brain structure in older adults with memory complaints: results from the CANN randomized, controlled parallel-design study
Am J Clin Nutr. 2023 Aug;118(2):369-381. doi: 10.1016/j.ajcnut.2023.06.008. Epub 2023 Jun 12. ABSTRACT BACKGROUND: There is evidence that both omega-3 long-chain polyunsaturated fatty acids (PUFAs)...
Anti-Alzheimer Activity of Combinations of Cocoa with Vinpocetine or Other Nutraceuticals in Rat Model: Modulation of Wnt3/β-Catenin/GSK-3β/Nrf2/HO-1 and PERK/CHOP/Bcl-2 Pathways
Pharmaceutics. 2023 Jul 31;15(8):2063. doi: 10.3390/pharmaceutics15082063. ABSTRACT Alzheimer’s disease (AD) is a devastating illness with limited therapeutic interventions. The aim of this study is to...
The Influence of APOE Genotype, DHA, and Flavanol Intervention on Brain DHA and Lipidomics Profile in Aged Transgenic Mice
Nutrients. 2023 Apr 23;15(9):2032. doi: 10.3390/nu15092032. ABSTRACT The apolipoprotein E4 (APOE4) genotype is predictive of Alzheimer’s disease (AD). The brain is highly enriched with the...
Cocoa flavanol supplementation preserves early and late radial artery function after transradial catheterization
Food Funct. 2023 May 22;14(10):4824-4835. doi: 10.1039/d3fo01116j. ABSTRACT Background: The transradial approach for coronary angiography is associated with fewer complications and preferred over the femoral...
A single dose of microencapsulated cocoa supplementation attenuated eccentric exercise-induced endothelial dysfunction
Int J Food Sci Nutr. 2023 May;74(3):373-381. doi: 10.1080/09637486.2023.2207783. Epub 2023 May 9. ABSTRACT In the present study, it was evaluated whether microencapsulated cocoa supplementation...
Suppression of tomato wilt by cell-free supernatants of Acinetobacter baumannii isolates from wild cacao from the Colombian Amazon
World J Microbiol Biotechnol. 2023 Sep 2;39(11):297. doi: 10.1007/s11274-023-03719-9. ABSTRACT Tomato vascular wilt caused by Fusarium oxysporum f. sp. lycopersici (Fol) is one of the...
Cocoa flavanols improve peakVO2 and exercise capacity in a randomized double blinded clinical trial in healthy elderly people
Food Funct. 2023 Aug 14;14(16):7562-7573. doi: 10.1039/d3fo01737k. ABSTRACT Background: Loss of functional capacity is one of the hallmarks in cardiovascular aging. Cocoa flavanols (CF) exert...
Exploring the Nutritional Composition and Bioactive Compounds in Different Cocoa Powders
Antioxidants (Basel). 2023 Mar 14;12(3):716. doi: 10.3390/antiox12030716. ABSTRACT Cocoa, the main derivative of the seeds of Theobroma cacao L., has been recognized to have several...
Flavan-3-ol-methylxanthine interactions: Modulation of flavan-3-ol bioavailability in volunteers with a functional colon and an ileostomy
Free Radic Biol Med. 2023 Jan 5:S0891-5849(23)00004-7. doi: 10.1016/j.freeradbiomed.2023.01.003. Online ahead of print. ABSTRACT Flavan-3-ols, including the flavan-3-ol monomer (-)-epicatechin, are dietary bioactives known to...
Mental Performance and Sport: Caffeine and Co-consumed Bioactive Ingredients
Sports Med. 2022 Nov 30. doi: 10.1007/s40279-022-01796-8. Online ahead of print. ABSTRACT The plant defence compound caffeine is widely consumed as a performance enhancer in...
Mental Performance and Sport: Caffeine and Co-consumed Bioactive Ingredients
Sports Med. 2022 Nov 30. doi: 10.1007/s40279-022-01796-8. Online ahead of print. ABSTRACT The plant defence compound caffeine is widely consumed as a performance enhancer in...
Fish oil and probiotics supplementation through milk chocolate improves spatial learning and memory in male Wistar rats
Front Nutr. 2022 Nov 17;9:1023653. doi: 10.3389/fnut.2022.1023653. eCollection 2022. NO ABSTRACT PMID:36466424 | PMC:PMC9712752 | DOI:10.3389/fnut.2022.1023653...
The action of phytochemicals present in cocoa in the prevention of vascular dysfunction and atherosclerosis
J Clin Transl Res. 2022 Nov 10;8(6):509-551. eCollection 2022 Dec 29. ABSTRACT BACKGROUND: Chronic non-communicable diseases, including cardiovascular diseases (CVDs), have caused many deaths worldwide....
Effect of an (-)-Epicatechin Intake on Cardiometabolic Parameters-A Systematic Review of Randomized Controlled Trials
Nutrients. 2022 Oct 26;14(21):4500. doi: 10.3390/nu14214500. ABSTRACT Growing evidence exists that consumption of cocoa-rich food improves the parameters of cardiometabolic health. These effects are ascribed...
Dark chocolate: An overview of its biological activity, processing, and fortification approaches
Curr Res Food Sci. 2022 Oct 15;5:1916-1943. doi: 10.1016/j.crfs.2022.10.017. eCollection 2022. ABSTRACT Dark chocolate gets popularity for several decades due to its enormous health benefits....