Widely assumed phenotypic associations in Cannabis sativa lack a shared genetic basis
PeerJ. 2021 Apr 20;9:e10672. doi: 10.7717/peerj.10672. eCollection 2021. ABSTRACT The flowering plant Cannabis sativa, cultivated for centuries for multiple purposes, displays extensive variation in phenotypic...
Evaluation of the Possible Anticonvulsant Effect of Δ9-Tetrahydrocannabinolic Acid in Murine Seizure Models
Cannabis Cannabinoid Res. 2022 Feb;7(1):46-57. doi: 10.1089/can.2020.0073. Epub 2020 Sep 9. ABSTRACT Introduction: The cannabinoid Δ9-tetrahydrocannabinolic acid (Δ9-THCA) has long been suggested in review articles...
Modulation of Recombinant Human T-Type Calcium Channels by Δ9-Tetrahydrocannabinolic Acid In Vitro
Cannabis Cannabinoid Res. 2022 Feb;7(1):34-45. doi: 10.1089/can.2020.0134. Epub 2021 Jan 21. ABSTRACT Introduction: Low voltage-activated T-type calcium channels (T-type ICa), CaV3.1, CaV3.2, and CaV3.3, are...
Cannabinoid Content in Cannabis Flowers and Homemade Cannabis-Based Products Used for Therapeutic Purposes in Argentina
Cannabis Cannabinoid Res. 2023 Feb;8(1):197-206. doi: 10.1089/can.2020.0117. Epub 2021 Mar 26. ABSTRACT Introduction: A recent law (DCTO-2020-883-APN-PTE-Law No. 27,350. Regulation) passed in Argentina put an...
LC-MS-MS Analysis of Δ9-THC, CBN and CBD in Hair: Investigation of Artifacts
J Anal Toxicol. 2022 May 20;46(5):504-511. doi: 10.1093/jat/bkab056. ABSTRACT In forensic toxicology, high-performance liquid chromatography tandem mass spectrometry (LC-MS-MS) is increasingly used for the fast...
Fast liquid chromatography-tandem mass spectrometry method for the simultaneous determination of phytocannabinoids in oily based preparations
J Pharm Biomed Anal. 2021 Sep 5;203:114174. doi: 10.1016/j.jpba.2021.114174. Epub 2021 May 26. ABSTRACT The reported method aims to be a powerful aid for the...
Development of a novel cannabinoid-loaded microemulsion towards an improved stability and transdermal delivery
Int J Pharm. 2021 Jul 15;604:120766. doi: 10.1016/j.ijpharm.2021.120766. Epub 2021 Jun 2. ABSTRACT The aim of this study was to develop a stable microemulsion (ME)...
Detectability of cannabinoids in the serum samples of cannabis users: Indicators of recent cannabis use? A follow-up study
Drug Test Anal. 2021 Sep;13(9):1614-1626. doi: 10.1002/dta.3110. Epub 2021 Jun 21. ABSTRACT Forensic toxicologists are frequently required to predict the time of last cannabis consumption....
In Situ Decarboxylation-Pressurized Hot Water Extraction for Selective Extraction of Cannabinoids from Cannabis sativa. Chemometric Approach
Molecules. 2021 Jun 2;26(11):3343. doi: 10.3390/molecules26113343. ABSTRACT Isolation of the therapeutic cannabinoid compounds from Cannabis Sativa L. (C. Sativa) is important for the development of...
Genomic and Chemical Diversity of Commercially Available High-CBD Industrial Hemp Accessions
Front Genet. 2021 Jul 7;12:682475. doi: 10.3389/fgene.2021.682475. eCollection 2021. ABSTRACT High consumer demand for cannabidiol (CBD) has made high-CBD hemp (Cannabis sativa) an extremely high-value...
The Highs and Lows of P Supply in Medical Cannabis: Effects on Cannabinoids, the Ionome, and Morpho-Physiology
Front Plant Sci. 2021 Jul 15;12:657323. doi: 10.3389/fpls.2021.657323. eCollection 2021. ABSTRACT Environmental conditions, including the availability of mineral nutrients, affect secondary metabolism in plants. Therefore,...
Evidence for adverse effects of cannabidiol (CBD) products and their non-conformity on the European food market – response to the European Industrial Hemp Association
F1000Res. 2020 Aug 26;9:1051. doi: 10.12688/f1000research.26045.2. eCollection 2020. ABSTRACT An interesting and valuable discussion has arisen from our recent article (Lachenmeier et al., 2020) and...
Cannabinoids Accumulation in Hemp (Cannabis sativa L.) Plants under LED Light Spectra and Their Discrete Role as a Stress Marker
Biology (Basel). 2021 Jul 24;10(8):710. doi: 10.3390/biology10080710. ABSTRACT Hemp adaptability through physiological and biochemical changes was studied under 10 LED light spectra and natural light...
Analysis of Sequence Variability and Transcriptional Profile of Cannabinoid synthase Genes in Cannabis sativa L. Chemotypes with a Focus on Cannabichromenic acid synthase
Plants (Basel). 2021 Sep 8;10(9):1857. doi: 10.3390/plants10091857. ABSTRACT Cannabis sativa L. has been long cultivated for its narcotic potential due to the accumulation of tetrahydrocannabinolic...
Valorization of CBD-hemp through distillation to provide essential oil and improved cannabinoids profile
Sci Rep. 2021 Oct 6;11(1):19890. doi: 10.1038/s41598-021-99335-4. ABSTRACT Hemp (Cannabis sativa L.) synthesizes and accumulates a number of secondary metabolites such as terpenes and cannabinoids....