In vitro and in vivo pharmacological activity of minor cannabinoids isolated from Cannabis sativa
Sci Rep. 2020 Nov 23;10(1):20405. doi: 10.1038/s41598-020-77175-y. ABSTRACT The Cannabis sativa plant contains more than 120 cannabinoids. With the exceptions of ∆9-tetrahydrocannabinol (∆9-THC) and cannabidiol...
Natural Salicylates and Their Roles in Human Health
Int J Mol Sci. 2020 Nov 28;21(23):9049. doi: 10.3390/ijms21239049. ABSTRACT Salicylic acid (SA) is a plant hormone which plays a crucial role in the plant...
Quantitation of Δ8-THC, Δ9-THC, Cannabidiol and 10 Other Cannabinoids and Metabolites in Oral Fluid by HPLC-MS-MS
J Anal Toxicol. 2022 Feb 14;46(1):76-88. doi: 10.1093/jat/bkaa184. ABSTRACT Quantitative analysis of Δ9-tetrahydrocannabinol (Δ9-THC) in oral fluid has gained increasing interest in clinical and forensic...
Rapid identification of drug-type and fiber-type cannabis by allele specific duplex PCR
Forensic Sci Int. 2021 Jan;318:110634. doi: 10.1016/j.forsciint.2020.110634. Epub 2020 Nov 26. ABSTRACT Cannabis is classified into two types: drug-type cannabis, which is abused worldwide, and...
The effect of cannabis toxicity on a model microbiome bacterium epitomized by a panel of bioluminescent E. coli
Chemosphere. 2021 Jan;263:128241. doi: 10.1016/j.chemosphere.2020.128241. Epub 2020 Sep 3. ABSTRACT The world acceptance of medical cannabis slowly widens. Cannabinoids are known as the main therapeutic...
Δ9-Tetrahydrocannabinolic Acid markedly alleviates liver fibrosis and inflammation in mice
Phytomedicine. 2021 Jan;81:153426. doi: 10.1016/j.phymed.2020.153426. Epub 2020 Nov 30. ABSTRACT BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the Western...
Disposition of Phytocannabinoids, Their Acidic Precursors and Their Metabolites in Biological Matrices of Healthy Individuals Treated with Vaporized Medical Cannabis
Pharmaceuticals (Basel). 2021 Jan 13;14(1):59. doi: 10.3390/ph14010059. ABSTRACT Inhalation by vaporization is a useful application mode for medical cannabis. In this study, we present the...
In vitro cholinesterase inhibitory action of Cannabis sativa L. Cannabaceae and in silico study of its selected phytocompounds
In Silico Pharmacol. 2021 Jan 21;9(1):13. doi: 10.1007/s40203-021-00075-0. eCollection 2021. ABSTRACT Cannabis sativa L. Cannabaceae, used for psychoactive rituals in Mesopotamia. Here, we investigated in...
A new Cannabis genome assembly associates elevated cannabidiol (CBD) with hemp introgressed into marijuana
New Phytol. 2021 May;230(4):1665-1679. doi: 10.1111/nph.17243. Epub 2021 Feb 28. ABSTRACT Demand for cannabidiol (CBD), the predominant cannabinoid in hemp (Cannabis sativa), has favored cultivars...
A single nucleotide polymorphism assay sheds light on the extent and distribution of genetic diversity, population structure and functional basis of key traits in cultivated north American cannabis
J Cannabis Res. 2020 Sep 11;2(1):26. doi: 10.1186/s42238-020-00036-y. ABSTRACT BACKGROUND: The taxonomic classification of Cannabis genus has been delineated through three main types: sativa (tall...
Δ9-Tetrahydrocannabinolic acid A, the precursor to Δ9-tetrahydrocannabinol (THC)
Acta Crystallogr C Struct Chem. 2021 Feb 1;77(Pt 2):84-89. doi: 10.1107/S2053229621000280. Epub 2021 Jan 14. ABSTRACT While Δ9-tetrahydrocannabinolic acid A (THCA-A) has been reported to...
SNP in Potentially Defunct Tetrahydrocannabinolic Acid Synthase Is a Marker for Cannabigerolic Acid Dominance in Cannabis sativa L
Genes (Basel). 2021 Feb 4;12(2):228. doi: 10.3390/genes12020228. ABSTRACT The regulation of cannabinoid synthesis in Cannabis sativa is of increasing research interest as restrictions around the...
Three novel transcription factors involved in cannabinoid biosynthesis in Cannabis sativa L
Plant Mol Biol. 2021 May;106(1-2):49-65. doi: 10.1007/s11103-021-01129-9. Epub 2021 Feb 24. ABSTRACT Three novel transcription factors were successfully identified and shown to interact with the...
Cannabichromene and Δ9-Tetrahydrocannabinolic Acid Identified as Lactate Dehydrogenase-A Inhibitors by in Silico and in Vitro Screening
J Nat Prod. 2021 May 28;84(5):1469-1477. doi: 10.1021/acs.jnatprod.0c01281. Epub 2021 Apr 22. ABSTRACT Cannabis sativa contains >120 phytocannabinoids, but our understanding of these compounds is...
CBG, CBD, Δ9-THC, CBN, CBGA, CBDA and Δ9-THCA as antioxidant agents and their intervention abilities in antioxidant action
Fitoterapia. 2021 Jul;152:104915. doi: 10.1016/j.fitote.2021.104915. Epub 2021 May 6. ABSTRACT Positive effect of some cannabinoids in the treatment and prophylaxis of a wide variety of...