Therapeutic potential of gamma entrainment using sensory stimulation for cognitive symptoms associated with schizophrenia
Neurosci Biobehav Rev. 2024 Apr 17;161:105681. doi: 10.1016/j.neubiorev.2024.105681. Online ahead of print. ABSTRACT Schizophrenia is a complex neuropsychiatric disorder with significant morbidity. Treatment options that...
Icariin attenuates vascular endothelial dysfunction by inhibiting inflammation through GPER/Sirt1/HMGB1 signaling pathway in type 1 diabetic rats
Chin J Nat Med. 2024 Apr;22(4):293-306. doi: 10.1016/S1875-5364(24)60618-7. ABSTRACT Icariin, a flavonoid glycoside, is extracted from Epimedium. This study aimed to investigate the vascular protective...
3D DLP-printed cannabinoid microneedles patch and its pharmacokinetic evaluation in rats
J Pharm Pharmacol. 2024 Apr 24:rgae043. doi: 10.1093/jpp/rgae043. Online ahead of print. ABSTRACT OBJECTIVE: The objective of the present study was to enhance the bioavailability...
Comparative Pharmacokinetic Assessment of Innovative Sublingual, Rectal and Vaporizer Cannabis Products Versus Approved Cannabis Products in Healthy Volunteers
Cannabis Cannabinoid Res. 2024 Apr 24. doi: 10.1089/can.2023.0229. Online ahead of print. ABSTRACT Background: Over the last years, there is a dramatic increase in the...
The Role of Cannabinoid-1 Receptor Ligands in the Ovalbumin-Induced Mouse Model of Allergic Asthma: Is It Related to Transient Receptor Potential Vanilloid-1 Channels?
Cannabis Cannabinoid Res. 2024 Apr 24. doi: 10.1089/can.2023.0151. Online ahead of print. ABSTRACT Objectives: The aim of this study was to investigate the role of...
The association between single and dual use of cannabis and alcohol and driving under the influence and riding with an impaired driver in a large sample of Canadian adolescents
Traffic Inj Prev. 2024 Apr 24:1-9. doi: 10.1080/15389588.2024.2342571. Online ahead of print. ABSTRACT OBJECTIVE: Dual use of cannabis and alcohol has increased in adolescents, but...
Cannabidiol attenuates seizure susceptibility and behavioural deficits in adult CDKL5R59X knock-in mice
Eur J Neurosci. 2024 Apr 23. doi: 10.1111/ejn.16350. Online ahead of print. ABSTRACT Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) is caused by a loss-of-function...
Physician Perceptions of Cannabidiol (CBD) and Cannabis in Sports Medicine and Performance
Transl Sports Med. 2023 Dec 11;2023:8824466. doi: 10.1155/2023/8824466. eCollection 2023. ABSTRACT OBJECTIVES: There is growing evidence regarding cannabinoid use in sports medicine and performance, especially...
Effects of recent cannabis consumption on eye-tracking and pupillometry
Front Neurosci. 2024 Apr 9;18:1358491. doi: 10.3389/fnins.2024.1358491. eCollection 2024. ABSTRACT INTRODUCTION: Cannabis consumption is known to immediately affect ocular and oculomotor function, however, cannabis consumption...
The Use of Tetrahydrocannabinol Is Associated with an Increase in Survival Time in Palliative Cancer Patients: A Retrospective Multicenter Cohort Study
Med Cannabis Cannabinoids. 2024 Mar 14;7(1):59-67. doi: 10.1159/000538311. eCollection 2024 Jan-Dec. ABSTRACT INTRODUCTION: Tetrahydrocannabinol (THC) is often prescribed for ambulatory palliative patients to improve sleep...
Effects of Cannabidiol and Δ9-Tetrahydrocannabinol on Cytochrome P450 Enzymes: A Systematic Review
Drug Metab Rev. 2024 Apr 24:1-20. doi: 10.1080/03602532.2024.2346767. Online ahead of print. ABSTRACT Due to legal, political, and cultural changes, the use of cannabis has...
Quantitative Estimation of Promoter Activity in Cannabis sativa Using Agroinfiltration-Based Transient Gene Expression
Methods Mol Biol. 2024;2787:245-253. doi: 10.1007/978-1-0716-3778-4_16. ABSTRACT To properly assess promoter activity, which is critical for understanding biosynthetic pathways in different plant species, we use...
DeLA-DrugSelf: Empowering multi-objective de novo design through SELFIES molecular representation
Comput Biol Med. 2024 Apr 16;175:108486. doi: 10.1016/j.compbiomed.2024.108486. Online ahead of print. ABSTRACT In this paper, we introduce DeLA-DrugSelf, an upgraded version of DeLA-Drug [J....
Endocannabinoid remodeling in murine cachexic muscle associates with catabolic and metabolic regulation
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 21:167179. doi: 10.1016/j.bbadis.2024.167179. Online ahead of print. ABSTRACT Muscle degeneration is a common feature in cancer cachexia...
Rapid Screening of New Psychoactive Substances Using pDART-QqQ-MS
J Am Soc Mass Spectrom. 2024 Apr 23. doi: 10.1021/jasms.4c00124. Online ahead of print. ABSTRACT Drug abuse is a severe social problem worldwide. Particularly, the...