Rapid Screening of New Psychoactive Substances Using pDART-QqQ-MS
J Am Soc Mass Spectrom. 2024 Apr 23. doi: 10.1021/jasms.4c00124. Online ahead of print. ABSTRACT Drug abuse is a severe social problem worldwide. Particularly, the...
A simple aptamer-dye fluorescence sensor for detecting Δ9-tetrahydrocannabinol and its metabolite in urban sewage
Chem Commun (Camb). 2024 Apr 23. doi: 10.1039/d4cc00824c. Online ahead of print. ABSTRACT This work developed an aptamer-dye complex as a label-free ratiometric fluorescence sensor...
Cannabidiol potentiates hyperpolarization-activated cyclic nucleotide-gated (HCN4) channels
J Gen Physiol. 2024 Jun 3;156(6):e202313505. doi: 10.1085/jgp.202313505. Epub 2024 Apr 23. ABSTRACT Cannabidiol (CBD), the main non-psychotropic phytocannabinoid produced by the Cannabis sativa plant,...
Genetic insights into agronomic and morphological traits of drug-type cannabis revealed by genome-wide association studies
Sci Rep. 2024 Apr 22;14(1):9162. doi: 10.1038/s41598-024-58931-w. ABSTRACT Cannabis sativa L., previously concealed by prohibition, is now a versatile and promising plant, thanks to recent...
Adolescent Cannabis Use and Suicidality
Am Fam Physician. 2024 Apr;109(4):369-370. NO ABSTRACT PMID:38648838...
Hexahydrocannabinol (HHC) and delta(9)-tetrahydrocannabinol (delta(9)-THC) driven activation of cannabinoid receptor 1 results in biased intracellular signaling
Sci Rep. 2024 Apr 22;14(1):9181. doi: 10.1038/s41598-024-58845-7. ABSTRACT The Cannabis sativa plant has been used for centuries as a recreational drug and more recently in...
Effects of Recreational Cannabis Legalization on Mental Health: Scoping Review
Psychiatr Serv. 2024 Apr 23:appips20230434. doi: 10.1176/appi.ps.20230434. Online ahead of print. ABSTRACT OBJECTIVE: Recreational cannabis legalization (RCL) is expanding rapidly. RCL’s effects on mental health...
Maternal Substance Use and Early-Life Adversity: Inducing Drug Dependence in Offspring, Interactions, Mechanisms, and Treatments
Addict Health. 2024 Feb;16(1):51-66. doi: 10.34172/ahj.2024.1478. Epub 2024 Feb 29. ABSTRACT The likelihood of substance dependency in offspring is increased in cases when there is...
Oral Delta-9-Tetrahydrocannabinol (THC) Increases Parasympathetic Activity and Supraspinal Conditioned Pain Modulation in Chronic Neuropathic Pain Male Patients: A Crossover, Double-Blind, Placebo-Controlled Trial
CNS Drugs. 2024 May;38(5):375-385. doi: 10.1007/s40263-024-01085-0. Epub 2024 Apr 10. ABSTRACT BACKGROUND: Disordered autonomic nervous system regulation and supraspinal pain inhibition have been repeatedly described...
A robust brain network for sustained attention from adolescence to adulthood that predicts later substance use
bioRxiv [Preprint]. 2024 Apr 5:2024.04.03.587900. doi: 10.1101/2024.04.03.587900. ABSTRACT Substance use, including cigarettes and cannabis, is associated with poorer sustained attention in late adolescence and early...
Long-lasting cigarette smoking alterations in immune function occur in cannabis smokers, possibly rendering them vulnerable to smoking-related tumors in later life
medRxiv [Preprint]. 2024 Apr 1:2024.04.01.24305156. doi: 10.1101/2024.04.01.24305156. ABSTRACT BACKGROUND: Active cigarette smoking leads to increased CXCL5 production. CXCL5 mediates the immune response by attracting immune...
Morphological and clinical findings in placentas and newborns with a history of tobacco, alcohol, and other substance abuse during pregnancy
J Neonatal Perinatal Med. 2024 Apr 13. doi: 10.3233/NPM-230104. Online ahead of print. ABSTRACT BACKGROUND: Exposure to toxins during pregnancy is the main modifiable behavior...
Age differences in patterns of cannabis use among an online US sample of adults who consume cannabis frequently
Am J Drug Alcohol Abuse. 2024 Apr 19:1-10. doi: 10.1080/00952990.2024.2309340. Online ahead of print. ABSTRACT Background: Cannabis use is increasing among middle-aged and older US...
Medicinal Cannabis oil improves anxiety-like and depressive-like behaviors in CCS mice via the BDNF/TRPC6 signaling pathway
Behav Brain Res. 2024 Apr 17:115005. doi: 10.1016/j.bbr.2024.115005. Online ahead of print. ABSTRACT BACKGROUND: Post-traumatic stress disorder (PTSD) refers to a chronic impairing psychiatric disorder...
Development and initial validation of the cannabis-related psychosis risk literacy scale (CPRL): a multinational psychometric study
BMC Psychiatry. 2024 Apr 19;24(1):298. doi: 10.1186/s12888-024-05727-x. ABSTRACT BACKGROUND: Public education efforts to address and reduce potential harms from cannabis use in Arab countries are...