Phytocannabinoids: Exploring Pharmacological Profiles and Their Impact on Therapeutical Use
Int J Mol Sci. 2024 Apr 10;25(8):4204. doi: 10.3390/ijms25084204. ABSTRACT Phytocannabinoids, a diverse group of naturally occurring compounds extracted from the Cannabis plant, have attracted...
Paclitaxel-Associated Mechanical Sensitivity and Neuroinflammation Are Sex-, Time-, and Site-Specific and Prevented through Cannabigerol Administration in C57Bl/6 Mice
Int J Mol Sci. 2024 Apr 12;25(8):4277. doi: 10.3390/ijms25084277. ABSTRACT Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most prevalent and dose-limiting complications in chemotherapy...
The Efficiency of CBD Production Using Grafted Cannabis sativa L. Plants Is Highly Dependent on the Type of Rootstock: A Study
Plants (Basel). 2024 Apr 17;13(8):1117. doi: 10.3390/plants13081117. ABSTRACT The global cannabis market is continuously expanding and as a result, the cannabis industry demands new and...
Cornflower Extract and Its Active Components Alleviate Dexamethasone-Induced Muscle Wasting by Targeting Cannabinoid Receptors and Modulating Gut Microbiota
Nutrients. 2024 Apr 11;16(8):1130. doi: 10.3390/nu16081130. ABSTRACT Sarcopenia, a decline in muscle mass and strength, can be triggered by aging or medications like glucocorticoids. This...
Exploring Microbial Metabolite Receptors in Inflammatory Bowel Disease: An In Silico Analysis of Their Potential Role in Inflammation and Fibrosis
Pharmaceuticals (Basel). 2024 Apr 12;17(4):492. doi: 10.3390/ph17040492. ABSTRACT Metabolites produced by dysbiotic intestinal microbiota can influence disease pathophysiology by participating in ligand-receptor interactions. Our aim...
Exploring Cannabinoids with Enhanced Binding Affinity for Targeting the Expanded Endocannabinoid System: A Promising Therapeutic Strategy for Alzheimer’s Disease Treatment
Pharmaceuticals (Basel). 2024 Apr 19;17(4):530. doi: 10.3390/ph17040530. ABSTRACT Despite decades of rigorous research and numerous clinical trials, Alzheimer’s disease (AD) stands as a notable healthcare...
A Novel Non-Psychoactive Fatty Acid from a Marine Snail, Conus inscriptus, Signals Cannabinoid Receptor 1 (CB1) to Accumulate Apoptotic C16:0 and C18:0 Ceramides in Teratocarcinoma Cell Line PA1
Molecules. 2024 Apr 11;29(8):1737. doi: 10.3390/molecules29081737. ABSTRACT The cannabinoid-type I (CB1) receptor functions as a double-edged sword to decide cell fate: apoptosis/survival. Elevated CB1 receptor...
CB1 Receptor Negative Allosteric Modulators as a Potential Tool to Reverse Cannabinoid Toxicity
Molecules. 2024 Apr 20;29(8):1881. doi: 10.3390/molecules29081881. ABSTRACT While the opioid crisis has justifiably occupied news headlines, emergency rooms are seeing many thousands of visits for...
Bipiperidinyl Derivatives of Cannabidiol Enhance Its Antiproliferative Effects in Melanoma Cells
Antioxidants (Basel). 2024 Apr 17;13(4):478. doi: 10.3390/antiox13040478. ABSTRACT Cannabis and its major cannabinoid cannabidiol (CBD) are reported to exhibit anticancer activity against skin tumors. However,...
Effects of Cannabidiol, ∆9-Tetrahydrocannabinol, and WIN 55-212-22 on the Viability of Canine and Human Non-Hodgkin Lymphoma Cell Lines
Biomolecules. 2024 Apr 19;14(4):495. doi: 10.3390/biom14040495. ABSTRACT In our previous study, we demonstrated the impact of overexpression of CB1 and CB2 cannabinoid receptors and the...
Heteromers Formed by GPR55 and Either Cannabinoid CB1 or CB2 Receptors Are Upregulated in the Prefrontal Cortex of Multiple Sclerosis Patients
Int J Mol Sci. 2024 Apr 10;25(8):4176. doi: 10.3390/ijms25084176. ABSTRACT Multiple sclerosis (MS) is an autoimmune, inflammatory, and neurodegenerative disease of the central nervous system...
Phytocannabinoids: Exploring Pharmacological Profiles and Their Impact on Therapeutical Use
Int J Mol Sci. 2024 Apr 10;25(8):4204. doi: 10.3390/ijms25084204. ABSTRACT Phytocannabinoids, a diverse group of naturally occurring compounds extracted from the Cannabis plant, have attracted...
Sharing Advice that We Give to People with Parkinson’s Disease
J Parkinsons Dis. 2024;14(3):361-362. doi: 10.3233/JPD-249003. NO ABSTRACT PMID:38669485 | DOI:10.3233/JPD-249003...
Improving the Decay Resistance of Wood through the Fixation of Different Nanoparticles Using Silica Aerogel
Gels. 2024 Apr 10;10(4):255. doi: 10.3390/gels10040255. ABSTRACT Nowadays, the protection of wood is becoming more important with the increasing demand for durable wood, in addition...
Antimicrobial, Probiotic, and Immunomodulatory Potential of Cannabis sativa Extract and Delivery Systems
Antibiotics (Basel). 2024 Apr 17;13(4):369. doi: 10.3390/antibiotics13040369. ABSTRACT The compounds present in hemp show multidirectional biological activity. It is related to the presence of secondary...