Placebo response in patients with Dravet syndrome: Post-hoc analysis of two clinical trials
Epilepsy Behav. 2024 Apr 26;156:109805. doi: 10.1016/j.yebeh.2024.109805. Online ahead of print. ABSTRACT OBJECTIVE: Dravet syndrome is a rare, early childhood-onset epileptic and developmental encephalopathy. Responses...
Phytocannabinoids in neuromodulation: from omics to epigenetics
J Ethnopharmacol. 2024 Apr 25:118201. doi: 10.1016/j.jep.2024.118201. Online ahead of print. ABSTRACT BACKGROUND: Recent developments in metabolomics, transcriptomic and epigenetics open up new horizons regarding...
Phytocannabinoids in neuromodulation: from omics to epigenetics
J Ethnopharmacol. 2024 Apr 25:118201. doi: 10.1016/j.jep.2024.118201. Online ahead of print. ABSTRACT BACKGROUND: Recent developments in metabolomics, transcriptomic and epigenetics open up new horizons regarding...
Trametes versicolor Laccase-Based Magnetic Inorganic-Protein Hybrid Nanobiocatalyst for Efficient Decolorization of Dyes in the Presence of Inhibitors
Materials (Basel). 2024 Apr 13;17(8):1790. doi: 10.3390/ma17081790. ABSTRACT In the present investigation, an ecofriendly magnetic inorganic-protein hybrid system-based enzyme immobilization was developed using partially purified...
Comparative Analysis of Viromes Identified in Multiple Macrofungi
Viruses. 2024 Apr 12;16(4):597. doi: 10.3390/v16040597. ABSTRACT Macrofungi play important roles in the soil elemental cycle of terrestrial ecosystems. Fungal viruses are common in filamentous...
Effectiveness of a universal, school-based, online programme for the prevention of anxiety, depression, and substance misuse among adolescents in Australia: 72-month outcomes from a cluster-randomised controlled trial
Lancet Digit Health. 2024 May;6(5):e334-e344. doi: 10.1016/S2589-7500(24)00046-3. ABSTRACT BACKGROUND: The CSC study found that the universal delivery of a school-based, online programme for the prevention...
An observational time-series study on the behavioral effects of adjunctive artisanal cannabidiol use by adults with treatment resistant epilepsies
BMC Neurol. 2024 Apr 26;24(1):141. doi: 10.1186/s12883-024-03646-8. ABSTRACT BACKGROUND: For approximately 30% of people with epilepsy, seizures are not well-controlled by anti-seizure medication (ASM). This...
Analysis of the Relationship between Psychiatric and Addiction-Related Disorders in Patients of an Outpatient Addiction Treatment Clinic for Children and Adolescents
Children (Basel). 2024 Mar 31;11(4):414. doi: 10.3390/children11040414. ABSTRACT INTRODUCTION: Dual diagnosis is used in addiction medicine to refer to the co-occurrence of an addiction-related disorder...
Bipiperidinyl Derivatives of Cannabidiol Enhance Its Antiproliferative Effects in Melanoma Cells
Antioxidants (Basel). 2024 Apr 17;13(4):478. doi: 10.3390/antiox13040478. ABSTRACT Cannabis and its major cannabinoid cannabidiol (CBD) are reported to exhibit anticancer activity against skin tumors. However,...
Neuromodulation for Cannabis Use: A Scoping Review
Brain Sci. 2024 Apr 2;14(4):356. doi: 10.3390/brainsci14040356. ABSTRACT This scoping review explores the use of neuromodulation techniques in individuals with cannabis use. Our goal was...
Sex-Specific Differences and the Role of Environmental Enrichment in the Expression of Hippocampal CB(1) Receptors following Chronic Unpredictable Stress
Brain Sci. 2024 Apr 3;14(4):357. doi: 10.3390/brainsci14040357. ABSTRACT Stress-related mental disorders have become increasingly prevalent, thus endangering mental health worldwide. Exploring stress-associated brain alterations is...
Immunostimulatory and Antibacterial Effects of Cannabis sativa L. Leaves on Broilers
Animals (Basel). 2024 Apr 11;14(8):1159. doi: 10.3390/ani14081159. ABSTRACT The aim of this study was to evaluate the effect of dried Cannabis sativa L. leaves as...
Increasing CB2 Receptor Activity after Early Life Stress Prevents Depressive Behavior in Female Rats
Biomolecules. 2024 Apr 10;14(4):464. doi: 10.3390/biom14040464. ABSTRACT Early adversity, the loss of the inhibitory GABAergic interneuron parvalbumin, and elevated neuroinflammation are associated with depression. Individuals...
Effects of Cannabidiol, ∆9-Tetrahydrocannabinol, and WIN 55-212-22 on the Viability of Canine and Human Non-Hodgkin Lymphoma Cell Lines
Biomolecules. 2024 Apr 19;14(4):495. doi: 10.3390/biom14040495. ABSTRACT In our previous study, we demonstrated the impact of overexpression of CB1 and CB2 cannabinoid receptors and the...
Heteromers Formed by GPR55 and Either Cannabinoid CB(1) or CB(2) Receptors Are Upregulated in the Prefrontal Cortex of Multiple Sclerosis Patients
Int J Mol Sci. 2024 Apr 10;25(8):4176. doi: 10.3390/ijms25084176. ABSTRACT Multiple sclerosis (MS) is an autoimmune, inflammatory, and neurodegenerative disease of the central nervous system...