Cannabidiol prevents chemotherapy-induced neuropathic pain by modulating spinal TLR4 via endocannabinoid system activation
J Pharm Pharmacol. 2023 Apr 17;75(5):655-665. doi: 10.1093/jpp/rgad023. ABSTRACT OBJECTIVES: This study aimed to investigate the effect of cannabidiol (CBD) on type 4 Toll-like receptors...
The CB1 cannabinoid receptor regulates autophagy in the tibialis anterior skeletal muscle in mice
Biol Res. 2023 Mar 25;56(1):14. doi: 10.1186/s40659-023-00426-5. ABSTRACT The endocannabinoid system (ECS) regulates energy metabolism, has been implicated in the pathogenesis of metabolic diseases and...
Endocannabinoid system as a therapeutic target for psychostimulants relapse: A systematic review of preclinical studies
Eur J Pharmacol. 2023 Jul 15;951:175669. doi: 10.1016/j.ejphar.2023.175669. Epub 2023 Mar 23. ABSTRACT The mechanism behind the reinstament of psychostimulant, as a major obstacle in...
The association of CNR1 genetic variants with resting-state functional connectivity in youth bipolar disorder
Eur Neuropsychopharmacol. 2023 Jun;71:41-54. doi: 10.1016/j.euroneuro.2023.03.004. Epub 2023 Mar 25. ABSTRACT Cannabinoid 1 receptors coded by the CNR1 gene are implicated in mood disorders and...
Cannabinoid type 2 receptor activation inhibits MPP+-induced M1 differentiation of microglia through activating PI3K/Akt/Nrf2 signal pathway
Mol Biol Rep. 2023 May;50(5):4423-4433. doi: 10.1007/s11033-023-08395-4. Epub 2023 Mar 28. ABSTRACT BACKGROUND: Growing evidence indicates that cannabinoid type 2 (CB2) receptor activation inhibits neuroinflammation...
Cannabinoid Receptor 1 Agonist ACEA and Cannabinoid Receptor 2 Agonist GW833972A Attenuates Cell-Mediated Immunity by Different Biological Mechanisms
Cells. 2023 Mar 9;12(6):848. doi: 10.3390/cells12060848. ABSTRACT Cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2) are components in the endocannabinoid system that play significant...
The Mechanisms of GPR55 Receptor Functional Selectivity during Apoptosis and Proliferation Regulation in Cancer Cells
Int J Mol Sci. 2023 Mar 14;24(6):5524. doi: 10.3390/ijms24065524. ABSTRACT GPR55 is a non-canonical cannabinoid receptor, important for cancer proliferation. Depending on the ligand, it...
Have recreational marijuana laws undermined public health progress on adult tobacco use?
J Health Econ. 2023 Jul;90:102756. doi: 10.1016/j.jhealeco.2023.102756. Epub 2023 Apr 5. ABSTRACT Public health experts caution that legalization of recreational marijuana may normalize smoking and...
The chronic pharmacological antagonism of the CB1 receptor is not involved in the behavioral effects of antidepressants administered in mice submitted to chronic unpredictable stress
Behav Brain Res. 2023 Jul 26;450:114502. doi: 10.1016/j.bbr.2023.114502. Epub 2023 May 19. ABSTRACT Several pieces of evidence suggest that the monoaminergic theory of depression cannot...
Pilot trial of a telehealth-delivered behavioral economic intervention promoting cannabis-free activities among adults with cannabis use disorder
J Psychiatr Res. 2023 Jul;163:202-210. doi: 10.1016/j.jpsychires.2023.05.012. Epub 2023 May 16. ABSTRACT BACKGROUND: Cannabis is increasingly consumed and increasingly perceived as harmless. Among those whose...
Forensic Mass Spectrometry: Scientific and Legal Precedents
J Am Soc Mass Spectrom. 2023 Jul 5;34(7):1210-1224. doi: 10.1021/jasms.3c00124. Epub 2023 Jun 5. ABSTRACT Mass spectrometry has made profound contributions to the criminal justice...
Trans-palmitoleic acid, a dairy fat biomarker, stimulates insulin secretion and activates G protein-coupled receptors with a different mechanism from the cis isomer
Food Funct. 2023 Jul 17;14(14):6496-6512. doi: 10.1039/d2fo03412c. ABSTRACT Dietary trans-palmitoleic acid (trans 16:1n-7, tPOA), a biomarker for high-fat dairy product intake, has been associated with...
Acetyl-l-carnitine restores synaptic transmission and enhances the inducibility of stable LTP after oxygen-glucose deprivation
Neuroscience. 2016 Sep 22;332:203-11. doi: 10.1016/j.neuroscience.2016.06.046. Epub 2016 Jul 1. ABSTRACT Hypoxic circumstances result in functional and structural impairments of the brain. Oxygen-glucose deprivation (OGD)...
Reply to Arduini et al.: Acetyl-l-carnitine and the brain: Epigenetics, energetics, and stress
Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):E5700-1. doi: 10.1073/pnas.1612347113. Epub 2016 Sep 12. NO ABSTRACT PMID:27621429 | PMC:PMC5047174 | DOI:10.1073/pnas.1612347113...
Acetyl-l-carnitine protects dopaminergic nigrostriatal pathway in 6-hydroxydopamine-induced model of Parkinson’s disease in the rat
Biomed Pharmacother. 2017 May;89:1-9. doi: 10.1016/j.biopha.2017.02.007. Epub 2017 Feb 12. ABSTRACT Parkinson’s disease (PD) is a movement disorder and the second most common neurodegenerative disease...