L-Carnitine and Acetyl-L-carnitine Roles and Neuroprotection in Developing Brain
Neurochem Res. 2017 Jun;42(6):1661-1675. doi: 10.1007/s11064-017-2288-7. Epub 2017 May 16. ABSTRACT L-Carnitine functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by...
ALCAR promote adult hippocampal neurogenesis by regulating cell-survival and cell death-related signals in rat model of Parkinson’s disease like-phenotypes
Neurochem Int. 2017 Sep;108:388-396. doi: 10.1016/j.neuint.2017.05.017. Epub 2017 May 31. ABSTRACT Parkinson’s disease (PD) is characterized by the degeneration of dopaminergic neurons in the nigrostriatal...
Acetyl-l-carnitine enhances myelination of regenerated fibers of the lateral olfactory tract
Neurosci Lett. 2017 Jul 13;653:215-219. doi: 10.1016/j.neulet.2017.06.001. Epub 2017 Jun 3. ABSTRACT It is well known that acetyl-l-carnitine (ALC) has various neuroprotective effects against neurodegenerative...
Dietary supplementation with acetyl-l-carnitine counteracts age-related alterations of mitochondrial biogenesis, dynamics and antioxidant defenses in brain of old rats
Exp Gerontol. 2017 Nov;98:99-109. doi: 10.1016/j.exger.2017.08.017. Epub 2017 Aug 12. ABSTRACT We previously reported the ability of dietary supplementation with acetyl-l-carnitine (ALCAR) to prevent age-related...
Neuroprotective effects of acetyl-l-carnitine on lipopolysaccharide-induced neuroinflammation in mice: Involvement of brain-derived neurotrophic factor
Neurosci Lett. 2017 Sep 29;658:32-36. doi: 10.1016/j.neulet.2017.07.059. Epub 2017 Aug 16. ABSTRACT Neuroinflammation is the inflammation of nervous tissue that can lead to neurodegeneration. Brain-derived...
Acetyl-L-Carnitine Attenuates Arsenic-Induced Oxidative Stress and Hippocampal Mitochondrial Dysfunction
Biol Trace Elem Res. 2018 Aug;184(2):422-435. doi: 10.1007/s12011-017-1210-0. Epub 2017 Nov 30. ABSTRACT Augmentation of mitochondrial oxidative stress through activating a series of deadly events...
The possible anti-apoptotic and antioxidant effects of acetyl l-carnitine as an add-on therapy on a relapsing-remitting model of experimental autoimmune encephalomyelitis in rats
Biomed Pharmacother. 2018 Jul;103:1302-1311. doi: 10.1016/j.biopha.2018.04.173. Epub 2018 May 7. ABSTRACT Multiple sclerosis (MS) is a progressive inflammatory autoimmune demyelinating disease of the brain and...
Neuroprotective effects of acetyl-l-carnitine (ALC) in a chronic MPTP-induced Parkinson’s disease mouse model: Endothelial and microglial effects
Neurosci Lett. 2019 Jun 11;703:86-95. doi: 10.1016/j.neulet.2019.03.015. Epub 2019 Mar 16. ABSTRACT Parkinson’s disease (PD) is a progressive motor disease with clinical features emerging due...
Acetyl-L-carnitine as a putative candidate for the treatment of stress-related psychiatric disorders: Novel evidence from a zebrafish model
Neuropharmacology. 2019 May 15;150:145-152. doi: 10.1016/j.neuropharm.2019.03.024. Epub 2019 Mar 24. ABSTRACT Stress-related psychiatric disorders are mental conditions that affect mood, cognition and behavior and arise...
Effect of Acetyl-L-carnitine Used for Protection of Neonatal Hypoxic-Ischemic Brain Injury on Acute Kidney Changes in Male and Female Rats
Neurochem Res. 2019 Oct;44(10):2405-2412. doi: 10.1007/s11064-019-02807-3. Epub 2019 Apr 30. ABSTRACT Neonatal hypoxia-ischemia (HI) is a common cause of brain injury in infants. Acute kidney...
Metabolic signature in nucleus accumbens for anti-depressant-like effects of acetyl-L-carnitine
Elife. 2020 Jan 10;9:e50631. doi: 10.7554/eLife.50631. ABSTRACT Emerging evidence suggests that hierarchical status provides vulnerability to develop stress-induced depression. Energy metabolic changes in the nucleus...
Neuroprotective efficacy of nano-CoQ against propionic acid toxicity in rats: Role of BDNF and CREB protein expressions
J Biochem Mol Toxicol. 2020 Apr;34(4):e22449. doi: 10.1002/jbt.22449. Epub 2020 Jan 22. ABSTRACT Propionic acid (PRA) is used as a food preservative. This study was...
Acetyl-l-carnitine does not prevent neurodegeneration in a rodent model of prolonged neonatal anesthesia
Neurotoxicol Teratol. 2020 Jul-Aug;80:106891. doi: 10.1016/j.ntt.2020.106891. Epub 2020 May 3. ABSTRACT Many studies have shown that prolonged or repeated use of general anesthesia early in...
Acetyl-L-Carnitine in Dementia and Other Cognitive Disorders: A Critical Update
Nutrients. 2020 May 12;12(5):1389. doi: 10.3390/nu12051389. ABSTRACT Several studies explored the effects of acetyl-L-carnitine (ALC) in dementia, suggesting a role in slowing down cognitive decline....
Moringa oleifera extract attenuates the CoCl2 induced hypoxia of rat’s brain: Expression pattern of HIF-1α, NF-kB, MAO and EPO
Biomed Pharmacother. 2019 Jan;109:1688-1697. doi: 10.1016/j.biopha.2018.11.019. Epub 2018 Nov 20. ABSTRACT Hypoxia-induced oxidative stress and apoptosis are the major hallmark explanations underlying brain dysfunction. Hypoxia...