Using Social Media Data to Investigate Public Perceptions of Cannabis as a Medicine: Narrative Review
J Med Internet Res. 2023 Feb 27;25:e36667. doi: 10.2196/36667. ABSTRACT BACKGROUND: The use and acceptance of medicinal cannabis is on the rise across the globe....
Role of Cannabinoid CB1 Receptor in Object Recognition Memory Impairment in Chronically Rapid Eye Movement Sleep-deprived Rats
Chin Med Sci J. 2023 Mar 31;38(1):29-37. doi: 10.24920/004087. ABSTRACT Objective We aimed to investigate whether antagonism of the cannabinoid CB1 receptor (CB1R) could affect...
Chronic exposure to a synthetic cannabinoid alters cerebral brain metabolism and causes long-lasting behavioral deficits in adult mice
J Neural Transm (Vienna). 2023 Aug;130(8):1013-1027. doi: 10.1007/s00702-023-02607-8. Epub 2023 Feb 28. ABSTRACT In recent years, there has been growing evidence that cannabinoids have promising...
Cnr1-/- has minimal impact on chlorpyrifos-mediated effects in the mouse endocannabinoid system, but it does alter lipopolysaccharide-induced cytokine levels in splenocytes
Chem Biol Interact. 2023 Apr 25;375:110425. doi: 10.1016/j.cbi.2023.110425. Epub 2023 Feb 27. ABSTRACT Chlorpyrifos (CPF) is an organophosphate pesticide that can inhibit endocannabinoid (eCB) metabolizing...
Endocannabinoids, anandamide and 2-AG, regulate mechanosensitivity of mucosal afferents in the Guinea pig bladder
Eur J Pharmacol. 2023 Apr 15;945:175624. doi: 10.1016/j.ejphar.2023.175624. Epub 2023 Feb 27. ABSTRACT Bladder afferents play a crucial role in urine storage and voiding, and...
The history, evolution, and practice of cannabis and E-cigarette industries highlight necessary public health and public safety considerations
J Safety Res. 2023 Feb;84:192-203. doi: 10.1016/j.jsr.2022.10.019. Epub 2022 Nov 11. NO ABSTRACT PMID:36868647 | DOI:10.1016/j.jsr.2022.10.019...
Pharmacologic antagonism of CB1 receptors improves electrophysiological alterations in Purkinje cells exposed to 3-AP
BMC Neurosci. 2023 Mar 3;24(1):18. doi: 10.1186/s12868-023-00786-4. ABSTRACT INTRODUCTION: Although ataxia is associated with cerebellar dysfunction, little is known about the effects of 3-AP exposure...
Bed nucleus of the stria terminalis CB1 receptors and the FAAH enzyme modulate anxiety behavior depending on previous stress exposure
Prog Neuropsychopharmacol Biol Psychiatry. 2023 Jul 13;125:110739. doi: 10.1016/j.pnpbp.2023.110739. Epub 2023 Mar 3. ABSTRACT The endocannabinoid (eCB) anandamide (AEA) is synthesized on-demand in the post-synaptic...
First-in-human imaging using [11C]MDTC: a radiotracer targeting the cannabinoid receptor type 2
Eur J Nucl Med Mol Imaging. 2023 Jul;50(8):2386-2393. doi: 10.1007/s00259-023-06170-y. Epub 2023 Mar 6. ABSTRACT PURPOSE: We report findings from the first-in-human study of [11C]MDTC,...
The Effects of Chronic Marijuana Administration on 6-OHDA-Induced Learning & Memory Impairment and Hippocampal Dopamine and Cannabinoid Receptors Interaction in Male Rats
Neurochem Res. 2023 Jul;48(7):2220-2229. doi: 10.1007/s11064-023-03899-8. Epub 2023 Mar 9. ABSTRACT There are general inhibitory effects of exo-cannabinoids on dopamine-mediated behaviors. Many studies suggested the...
GPR55 contributes to neutrophil recruitment and mechanical pain induction after spinal cord compression in mice
Brain Behav Immun. 2023 May;110:276-287. doi: 10.1016/j.bbi.2023.03.008. Epub 2023 Mar 8. ABSTRACT Pain transmission and processing in the nervous system are modulated by various biologically...
Cannabinoid-1 receptor activation modulates lipid mobilization and adipogenesis in the adipose tissue of dairy cows
J Dairy Sci. 2023 May;106(5):3650-3661. doi: 10.3168/jds.2022-22556. Epub 2023 Mar 10. ABSTRACT Amplified adipose tissue (AT) lipolysis and suppressed lipogenesis characterize the periparturient period of...
Structural basis of selective cannabinoid CB2 receptor activation
Nat Commun. 2023 Mar 15;14(1):1447. doi: 10.1038/s41467-023-37112-9. ABSTRACT Cannabinoid CB2 receptor (CB2R) agonists are investigated as therapeutic agents in the clinic. However, their molecular mode-of-action...
Somatic and terminal CB1 receptors are differentially coupled to voltage-gated sodium channels in neocortical neurons
Cell Rep. 2023 Mar 28;42(3):112247. doi: 10.1016/j.celrep.2023.112247. Epub 2023 Mar 17. ABSTRACT Endogenous cannabinoid signaling is vital for important brain functions, and the same pathways...
Development of the High-Affinity Carborane-Based Cannabinoid Receptor Type 2 PET Ligand [18F]LUZ5-d8
J Med Chem. 2023 Apr 13;66(7):5242-5260. doi: 10.1021/acs.jmedchem.3c00195. Epub 2023 Mar 21. ABSTRACT The development of cannabinoid receptor type 2 (CB2R) radioligands for positron emission...