Disparities in cannabis use and documentation in electronic health records among children and young adults
NPJ Digit Med. 2023 Aug 8;6(1):138. doi: 10.1038/s41746-023-00885-w. ABSTRACT The legalizations of medical and recreational cannabis have generated a great deal of interest in studying...
Prevalence and factors associated with suicidal ideation, cannabis, and alcohol use during the COVID-19 pandemic in Saskatchewan: findings from a joint-effect modeling
BMC Psychiatry. 2023 Aug 8;23(1):571. doi: 10.1186/s12888-023-05051-w. ABSTRACT BACKGROUND: Generally, pandemics such as COVID-19 take an enormous toll on people’s lives. As the pandemic now...
Daily cannabis use may cause cannabis-induced hyperalgesia
Am J Addict. 2023 Aug 7. doi: 10.1111/ajad.13456. Online ahead of print. ABSTRACT BACKGROUND AND OBJECTIVES: Public opinion about cannabis as a medical treatment is...
A systematic review of economic evaluations for opioid misuse, cannabis and illicit drug use prevention
BJPsych Open. 2023 Aug 8;9(5):e149. doi: 10.1192/bjo.2023.515. ABSTRACT BACKGROUND: Substance use disorders negatively affect global disease burden. Effective preventive interventions are available, but whether they...
Starches modification with rose polyphenols under multi-frequency power ultrasonic fields: Effect on physicochemical properties and digestion behavior
Ultrason Sonochem. 2023 Aug;98:106515. doi: 10.1016/j.ultsonch.2023.106515. Epub 2023 Jul 4. ABSTRACT As the main source of energy for human beings, starch is widely present in...
Lysophosphatidylglucoside/GPR55 signaling promotes foam cell formation in human M2c macrophages
Sci Rep. 2023 Aug 6;13(1):12740. doi: 10.1038/s41598-023-39904-x. ABSTRACT Atherosclerosis is a major cause of cerebral and cardiovascular diseases. Intravascular plaques, a well-known pathological finding of...
Discovery of 4-(1,2,4-Oxadiazol-5-yl)azepan-2-one Derivatives as a New Class of Cannabinoid Type 2 Receptor Agonists for the Treatment of Inflammatory Pain
J Med Chem. 2023 Mar 9;66(5):3460-3483. doi: 10.1021/acs.jmedchem.2c01943. Epub 2023 Feb 23. ABSTRACT Selectively targeting the cannabinoid receptor CB2 is an attractive therapeutic strategy for...
Hippocampal expression of the cannabinoid receptor type 1 in canine epilepsy
Sci Rep. 2023 Feb 23;13(1):3138. doi: 10.1038/s41598-023-29868-3. ABSTRACT Canine drug-resistant epilepsy is a prevailing issue in veterinary neurology. Alternative or additional treatment with cannabinoids is...
CB2 Receptor as Emerging Anti-Inflammatory Target in Duchenne Muscular Dystrophy
Int J Mol Sci. 2023 Feb 7;24(4):3345. doi: 10.3390/ijms24043345. ABSTRACT Duchenne Muscular Dystrophy (DMD) is a very severe X-linked dystrophinopathy. It is due to a...
The Plant Derived 3-3′-Diindolylmethane (DIM) Behaves as CB2 Receptor Agonist in Prostate Cancer Cellular Models
Int J Mol Sci. 2023 Feb 11;24(4):3620. doi: 10.3390/ijms24043620. ABSTRACT 3-3′-Diindolylmethane (DIM) is a biologically active dimer derived from the endogenous conversion of indole-3-carbinol (I3C),...
The Cannabinoid Ligand Arachidonyl-2′-Chloroethylamide (ACEA) Ameliorates Depressive and Overactive Bladder Symptoms in a Corticosterone-Induced Female Wistar Rat Model
Int J Mol Sci. 2023 Feb 14;24(4):3820. doi: 10.3390/ijms24043820. ABSTRACT There is growing need to increase the knowledge on the cannabinoid ligands in the treatment...
Cannabinoid Receptor 2 Blockade Prevents Anti-Depressive-like Effect of Cannabidiol Acid Methyl Ester in Female WKY Rats
Int J Mol Sci. 2023 Feb 14;24(4):3828. doi: 10.3390/ijms24043828. ABSTRACT The pathophysiology of major depressive disorder (MDD) is diverse and multi-factorial, yet treatment strategies remain...
The Anti-Tumorigenic Role of Cannabinoid Receptor 2 in Colon Cancer: A Study in Mice and Humans
Int J Mol Sci. 2023 Feb 17;24(4):4060. doi: 10.3390/ijms24044060. ABSTRACT The endocannabinoid system, particularly cannabinoid receptor 2 (CB2 in mice and CNR2 in humans), has...
All-Atom Molecular Dynamics Simulations Indicated the Involvement of a Conserved Polar Signaling Channel in the Activation Mechanism of the Type I Cannabinoid Receptor
Int J Mol Sci. 2023 Feb 20;24(4):4232. doi: 10.3390/ijms24044232. ABSTRACT The type I cannabinoid G protein-coupled receptor (CB1, GPCR) is an intensely investigated pharmacological target,...
Structure-Based Virtual Screening and Molecular Dynamics Simulation Assessments of Depsidones as Possible Selective Cannabinoid Receptor Type 2 Agonists
Molecules. 2023 Feb 13;28(4):1761. doi: 10.3390/molecules28041761. ABSTRACT The discovery of natural drug metabolites is a leading contributor to fulfilling the sustainable development goal of finding...