Doxorubicin-induced senescence in normal fibroblasts promotes in vitro tumour cell growth and invasiveness: the role of Quercetin in modulating these processes
Mech Ageing Dev. 2022 Jun 18:111689. doi: 10.1016/j.mad.2022.111689. Online ahead of print. ABSTRACT Ageing is a complex biological phenomenon representing the major risk factor for...
The Effects of Novel Formulations of Edaravone and Curcumin in the Mouse Intrastriatal Lipopolysaccharide Model of Parkinson’s Disease
Front Biosci (Schol Ed). 2022 May 7;14(2):13. doi: 10.31083/j.fbs1402013. ABSTRACT The major hallmark of Parkinson’s disease (PD) is the degeneration of dopaminergic neurons in the...
ViphyllinTM, a Standardized Black Pepper Extract Exerts Antihyperglycemic Effect and Improves Sciatic Nerve Conduction in High Fat Diet/Streptozotocin-Induced Diabetic Model Rats
Diabetes Metab Syndr Obes. 2022 Jun 15;15:1819-1829. doi: 10.2147/DMSO.S366609. eCollection 2022. ABSTRACT PURPOSE: Research on plant-based formulations has drawn considerable attention in the management of...
Phytochemical quercetin alleviates hyperexcitability of trigeminal nociceptive neurons associated with inflammatory hyperalgesia comparable to NSAIDs
Mol Pain. 2022 Apr;18:17448069221108971. doi: 10.1177/17448069221108971. ABSTRACT Quercetin is a flavonoid that is widely found in fruits and vegetables. Quercetin inhibits cyclooxygenase-2 and modulates voltage-gated...
Curcumin Alleviates Arsenic Trioxide-Induced Inflammation and Pyroptosis via the NF-κB/NLRP3 Signaling Pathway in the Hypothalamus of Ducks
Biol Trace Elem Res. 2022 Jun 23. doi: 10.1007/s12011-022-03321-4. Online ahead of print. ABSTRACT Arsenic (As) as a neurotoxic environmental pollutant has attracted extensive attention....
Formulated Curcumin Prevents Paclitaxel-Induced Peripheral Neuropathy through Reduction in Neuroinflammation by Modulation of α7 Nicotinic Acetylcholine Receptors
Pharmaceutics. 2022 Jun 17;14(6):1296. doi: 10.3390/pharmaceutics14061296. ABSTRACT Paclitaxel is widely used in the treatment of various types of solid malignancies. Paclitaxel-induced peripheral neuropathy (PIPN) is...
Hemp Seed Fermented by Aspergillus oryzae Attenuates Lipopolysaccharide-Stimulated Inflammatory Responses in N9 Microglial Cells
Foods. 2022 Jun 9;11(12):1689. doi: 10.3390/foods11121689. ABSTRACT The objective of our present work was to explore the possible enhanced anti-neuroinflammatory ability of Aspergillus oryzae fermented...
Computational approach to decode the mechanism of curcuminoids against neuropathic pain
Comput Biol Med. 2022 Jun 23;147:105739. doi: 10.1016/j.compbiomed.2022.105739. Online ahead of print. ABSTRACT BACKGROUND: Curcumin (CUR), demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC) are the main components...
Viphyllin™, a standardized extract from black pepper seeds, mitigates intestinal inflammation, oxidative stress, and anxiety-like behavior in DSS-induced colitis mice
J Food Biochem. 2022 Jun 29:e14306. doi: 10.1111/jfbc.14306. Online ahead of print. ABSTRACT Inflammatory bowel diseases (IBD) are the common health concern in populations across...
A Combination of Curcuma longa and Diazepam Attenuates Seizures and Subsequent Hippocampal Neurodegeneration
Front Cell Neurosci. 2022 Jun 14;16:884813. doi: 10.3389/fncel.2022.884813. eCollection 2022. ABSTRACT Epilepsy is one of the most common neurological disorders, which occurs due to the...
Zinc-curcumin based complexes in health and diseases: An approach in chemopreventive and therapeutic improvement
J Trace Elem Med Biol. 2022 Jun 20;73:127023. doi: 10.1016/j.jtemb.2022.127023. Online ahead of print. ABSTRACT Curcumin, a polyphenolic compound isolated from turmeric rhizome, displays antioxidant,...
Curcumin-Attenuated TREM-1/DAP12/NLRP3/Caspase-1/IL1B, TLR4/NF-κB Pathways, and Tau Hyperphosphorylation Induced by 1,2-Diacetyl Benzene: An in Vitro and in Silico Study
Neurotox Res. 2022 Jul 4. doi: 10.1007/s12640-022-00535-1. Online ahead of print. ABSTRACT We aimed to evaluate the effects of 1,2-diacetylbenzene (DAB) and curcumin on neuroinflammation...
The Effects of Nano-Curcumin Supplementation on Leptin and Adiponectin in Migraine Patients: A Double-Blind Clinical Trial Study from Gene Expression to Clinical Symptoms
Endocr Metab Immune Disord Drug Targets. 2022 Jul 1. doi: 10.2174/1871530322666220701100817. Online ahead of print. ABSTRACT BACKGROUND: Migraine is a disabling neurogenic disorder characterized by...
Review on the Therapeutic Potential of Curcumin and its Derivatives on Glioma Biology
Neurochem Res. 2022 Jul 5. doi: 10.1007/s11064-022-03666-1. Online ahead of print. ABSTRACT Gliomas are common and aggressive brain tumors that carry a poor prognosis. The...
Ameliorating potential of curcumin and its analogue in central nervous system disorders and related conditions: A review of molecular pathways
Phytother Res. 2022 Jul 4. doi: 10.1002/ptr.7522. Online ahead of print. ABSTRACT Curcumin, isolated from turmeric (Curcuma longa L.) is one of the broadly studied...