HomeDiseaseThe Effects of Nano-Curcumin Supplementation on Leptin and Adiponectin in Migraine Patients: A Double-Blind Clinical Trial Study from Gene Expression to Clinical Symptoms

The Effects of Nano-Curcumin Supplementation on Leptin and Adiponectin in Migraine Patients: A Double-Blind Clinical Trial Study from Gene Expression to Clinical Symptoms

August 20, 2022

Endocr Metab Immune Disord Drug Targets. 2022 Jul 1. doi: 10.2174/1871530322666220701100817. Online ahead of print.

ABSTRACT

BACKGROUND: Migraine is a disabling neurogenic disorder characterized by recurrent headache attacks. Adipokines act as inflammatory and pain mediators contribute to migraine pathogenesis. Leptin and adiponectin levels change in migraine patients and are associated with headache attacks. Curcumin can exert modulatory and analgesic effects on adipokines trough several mechanisms from gene expression to suppressing pain. The aim of the present study was to evaluate the effects of nano-curcumin supplementation on leptin and adiponectin gene expression, their serum levels and migraine symptoms in patients with migraine.

METHODS: Forty-four episodic migraine patients enrolled in this trial and were divided into two groups as nano-curcumin (80 mg/day) and placebo group over a two-month period. At the beginning and the end of the study, the mRNA expression of leptin and adiponectin from isolated PBMCs and their serum levels were measured using real-time PCR and ELISA method respectively. The headache frequencies, severity and duration of pain were also recorded.

RESULTS: The results of the present research showed that nano-curcumin can up-regulate adiponectin mRNA and increase its serum level significantly (P<0.05). In the case of leptin, a reduction in gene expression and concentration were found in nano-curcumin group but were not statistically significant (P>0.05). Nano-curcumin also significantly reduced the frequency, severity and duration of headaches (P<0.05).

CONCLUSION: These findings indicate that nano-curcumin supplement can be considered as a promising approach in migraine management and clinical symptoms improvement.

PMID:35786344 | DOI:10.2174/1871530322666220701100817

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About The Author

Patrick Blanchard MD

Meet Dr. Blanchard Dr. Blanchard’s medical practice is an embodiment of Integrative health which brings conventional and complementary approaches together in a coordinated way. Conveniently located in sunny Florida and over the internet with ValiseMD’s secure HIPPA compliant telXmed servers. Since 1994, patients with a wide range of challenging medical problems have achieved optimum health using the best of natural medicine, judiciously combined with high-tech innovations. Breakthroughs are often achieved even after patients have consulted mainstream specialists and holistic practitioners. Dr. Blanchard is founder and CEO of ValiseMD, Inc. He is board certified in Family Medicine since 1994 and awarded Fellow of the American Academy of Family Physicians in 2001. He received the ‘Teacher of the Year’ award from the University of Kansas School of Medicine at completion of his residency in Family Medicine. He completed a fellowship at Wake Forest University in the field of vascular neurosonology. He holds a medical patent in the field of Gastroenterology. He holds an unrestricted license to practice medicine and surgery in Florida. He started his medical career as a Emergency Medical Technician, then as a Paramedic and later a Medical Doctor.