Mechanistic perspectives on differential mitochondrial-based neuroprotective effects of several carnitine forms in Alzheimer’s disease in vitro model
Arch Toxicol. 2021 Aug;95(8):2769-2784. doi: 10.1007/s00204-021-03104-1. Epub 2021 Jun 24. ABSTRACT Mitochondrial deregulation has emerged as one of the earliest pathological events in Alzheimer’s disease...
Intergenerational trauma transmission is associated with brain metabotranscriptome remodeling and mitochondrial dysfunction
Commun Biol. 2021 Jun 24;4(1):783. doi: 10.1038/s42003-021-02255-2. ABSTRACT Intergenerational trauma increases lifetime susceptibility to depression and other psychiatric disorders. Whether intergenerational trauma transmission is a...
Tryptophan, kynurenine pathway, and diabetic ketoacidosis in type 1 diabetes
PLoS One. 2021 Jul 19;16(7):e0254116. doi: 10.1371/journal.pone.0254116. eCollection 2021. ABSTRACT Diabetic ketoacidosis (DKA) is a serious complication of complete insulin deficiency and insulin resistance in...
Correlation between acute brain injury and brain metabonomics in dichlorvos-poisoned broilers
J Hazard Mater. 2022 Jan 15;422:126849. doi: 10.1016/j.jhazmat.2021.126849. Epub 2021 Aug 8. ABSTRACT Dichlorvos (DDVP) is an insecticide with neurotoxicity that is widely used in...
Acetyl-L-carnitine in chronic pain: A narrative review
Pharmacol Res. 2021 Nov;173:105874. doi: 10.1016/j.phrs.2021.105874. Epub 2021 Sep 7. ABSTRACT Acetyl-L-carnitine (ALC) is an endogenous molecule that not only plays a role in energy...
Cerebellar mitochondrial dysfunction and concomitant multi-system fatty acid oxidation defects are sufficient to discriminate PTSD-like and resilient male mice
Brain Behav Immun Health. 2020 Jul 8;6:100104. doi: 10.1016/j.bbih.2020.100104. eCollection 2020 Jul. ABSTRACT The impact of trauma on mental health is complex with poorly understood...
L-Carnitine and Acetyl-L-Carnitine: Potential Novel Biomarkers for Major Depressive Disorder
Front Psychiatry. 2021 Sep 30;12:671151. doi: 10.3389/fpsyt.2021.671151. eCollection 2021. ABSTRACT The lack of biomarkers greatly limits the diagnosis and treatment of major depressive disorder (MDD)....
Quantification of Differential Metabolites in Dried Blood Spots Using Second-Tier Testing for SCADD/IBDD Disorders Based on Large-Scale Newborn Screening in a Chinese Population
Front Pediatr. 2021 Nov 19;9:757424. doi: 10.3389/fped.2021.757424. eCollection 2021. ABSTRACT Background: Although newborn screening (NBS) for metabolic defects using the marker butyl carnitine (C4) combined...
Non-targeted Metabolomics Profiling of Plasma Samples From Patients With Major Depressive Disorder
Front Psychiatry. 2022 Feb 21;12:810302. doi: 10.3389/fpsyt.2021.810302. eCollection 2021. ABSTRACT BACKGROUND: Major depressive disorder (MDD) is a neuropsychiatric disorder caused by multiple factors. Although there...
Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety Treatments (CANMAT) Taskforce
World J Biol Psychiatry. 2022 Mar 21:1-32. doi: 10.1080/15622975.2021.2013041. Online ahead of print. ABSTRACT OBJECTIVES: The therapeutic use of nutrient-based ‘nutraceuticals’ and plant-based ‘phytoceuticals’ for...
Acetyl-L-Carnitine Exerts Neuroprotective and Anticonvulsant Effect in Kainate Murine Model of Temporal Lobe Epilepsy
J Mol Neurosci. 2022 Jun;72(6):1224-1233. doi: 10.1007/s12031-022-01999-8. Epub 2022 Mar 23. ABSTRACT The most well-known type of focal epilepsy that is resistant to existing treatments...
Acute Lymphoblastic Leukemia in Combined Methylmalonic Acidemia and Homocysteinemia (cblC Type): A Case Report and Literature Review
Front Genet. 2022 Apr 14;13:856552. doi: 10.3389/fgene.2022.856552. eCollection 2022. ABSTRACT Background: Methylmalonic acidemia (MMA) can display many clinical manifestations, among which acute lymphoblastic leukemia (ALL)...
Acetyl-L-carnitine and/or liposomal co-enzyme Q10 prevent propionic acid-induced neurotoxicity by modulating oxidative tissue injury, inflammation, and ALDH1A1-RA-RARα signaling in rats
Biomed Pharmacother. 2022 Jul 1;153:113360. doi: 10.1016/j.biopha.2022.113360. Online ahead of print. ABSTRACT Propionic acid (PPA) is a short-chain fatty acid produced endogenously by gut microbiota...
Clinical Evidence of Acetyl-L-Carnitine Efficacy in the Treatment of Acute Ischemic Stroke: A Pilot Clinical Trial
Oxid Med Cell Longev. 2022 Jul 29;2022:2493053. doi: 10.1155/2022/2493053. eCollection 2022. ABSTRACT BACKGROUND: This study was undertaken to evaluate the influence of oral Acetyl-L-carnitine (ALC)...
Acetyl-L-carnitine attenuates Poly I: C- induced sickness behavior in mice
Biosci Biotechnol Biochem. 2022 Aug 9:zbac132. doi: 10.1093/bbb/zbac132. Online ahead of print. ABSTRACT Fatigue is accompanied by a decrease in physical activity or malaise, and...