Plant-Based Natural Products for the Discovery and Development of Novel Anthelmintics against Nematodes
Biomolecules. 2020 Mar 9;10(3):426. doi: 10.3390/biom10030426. ABSTRACT Intestinal parasitic nematodes infect approximately two billion people worldwide. In the absence of vaccines for human intestinal nematodes,...
Systematic Evaluation of the Mechanisms of Mulberry Leaf (Morus alba Linne) Acting on Diabetes Based on Network Pharmacology and Molecular Docking
Comb Chem High Throughput Screen. 2021;24(5):668-682. doi: 10.2174/1386207323666200914103719. ABSTRACT BACKGROUND: Diabetes mellitus is one of the most common endocrine metabolic disorder- related diseases. The application...
Herbal pair Huangqin-Baishao: mechanisms underlying inflammatory bowel disease by combined system pharmacology and cell experiment approach
BMC Complement Med Ther. 2020 Sep 25;20(1):292. doi: 10.1186/s12906-020-03068-2. ABSTRACT BACKGROUND: Inflammatory bowel disease (IBD) is a severe digestive system condition, characterized by chronic and...
Integrated network pharmacology and molecular docking strategy to explore the mechanism of medicinal and edible Astragali Radix-Atractylodis Macrocephalae Rhizoma acting on pneumonia via immunomodulation
J Food Biochem. 2020 Dec;44(12):e13510. doi: 10.1111/jfbc.13510. Epub 2020 Oct 6. ABSTRACT Pneumonia refers to a death-causing infection. Astragali Radix (AR) and Atractylodis Macrocephalae Rhizoma...
The synergic renoprotective effect of Rehmanniae Radix Preparata and Corni Fructus on adenine-induced chronic kidney disease rats based on integrated plasma metabolomics and network pharmacology approach
Life Sci. 2021 Aug 1;278:119545. doi: 10.1016/j.lfs.2021.119545. Epub 2021 Apr 27. ABSTRACT AIMS: Rehmanniae Radix Preparata (RR) and Corni Fructus (CF) are commonly used together...
Potential of Silver Nanoparticles in Overcoming the Intrinsic Resistance of Pseudomonas aeruginosa to Secondary Metabolites from Carnivorous Plants
Int J Mol Sci. 2021 May 3;22(9):4849. doi: 10.3390/ijms22094849. ABSTRACT Carnivorous plants are exemplary natural sources of secondary metabolites with biological activity. However, the therapeutic...
Protection against UVB deleterious skin effects in a mouse model: effect of a topical emulsion containing Cordia verbenacea extract
Photochem Photobiol Sci. 2021 Aug;20(8):1033-1051. doi: 10.1007/s43630-021-00079-x. Epub 2021 Jul 23. ABSTRACT Cordia verbenacea DC (Boraginaceae) is a flowering shrub found along the Brazilian Atlantic...
α-Glucosidase Inhibition Action of Major Flavonoids Identified from Hypericum Attenuatum Choisy and Their Synergistic Effects
Chem Biodivers. 2021 Oct;18(10):e2100244. doi: 10.1002/cbdv.202100244. Epub 2021 Sep 17. ABSTRACT Hypericum attenuatum Choisy is a traditional Chinese herbal plant with multiple therapeutic effects. In...
Synergistic Antibacterial Activity of an Active Compound Derived from Sedum takesimense against Methicillin-Resistant Staphylococcus aureus and Its Clinical Isolates
J Microbiol Biotechnol. 2021 Sep 28;31(9):1288-1294. doi: 10.4014/jmb.2105.05015. ABSTRACT There are a growing number of reports of hospital-acquired infections caused by pathogenic bacteria, especially methicillin-resistant...
Inhibition of Bacterial Efflux Pumps by Crude Extracts and Essential Oil from Myristica fragrans Houtt. (Nutmeg) Seeds against Methicillin-Resistant Staphylococcus aureus
Molecules. 2021 Jul 31;26(15):4662. doi: 10.3390/molecules26154662. ABSTRACT Myristicafragrans Houtt. (Nutmeg) is a widely known folk medicine across several parts of Asia, particularly used in antimicrobial...
Combination Therapy for Bacterial Pathogens: Naturally Derived Antimicrobial Drugs Combined with Ulva lactuca Extract
Infect Disord Drug Targets. 2022;22(1):e230821195790. doi: 10.2174/1871526521666210823164842. ABSTRACT BACKGROUND: With the growing incidence of microbial pathogenesis, several alternative strategies have been developed. The number of...
Principal Metabolites in Extracts of Different Plants Responsible for Antibacterial Effects
Chem Res Toxicol. 2021 Sep 20;34(9):1970-1983. doi: 10.1021/acs.chemrestox.1c00161. Epub 2021 Aug 31. ABSTRACT The increase in bacterial resistance and decreased effectiveness of antibacterial agents has...
Bruguiera gymnorhiza (L.) Lam. at the Forefront of Pharma to Confront Zika Virus and Microbial Infections-An In Vitro and In Silico Perspective
Molecules. 2021 Sep 23;26(19):5768. doi: 10.3390/molecules26195768. ABSTRACT The recent emergence of Zika virus (ZIKV) in Brazil and the increasing resistance developed by pathogenic bacteria to...
The Influence of Tea Tree Oil on Antifungal Activity and Pharmaceutical Characteristics of Pluronic® F-127 Gel Formulations with Ketoconazole
Int J Mol Sci. 2021 Oct 20;22(21):11326. doi: 10.3390/ijms222111326. ABSTRACT Fungal skin infections are currently a major clinical problem due to their increased occurrence and...
Exploring the synergistic and complementary effects of berberine and paeoniflorin in the treatment of type 2 diabetes mellitus by network pharmacology
Eur J Pharmacol. 2022 Mar 15;919:174769. doi: 10.1016/j.ejphar.2022.174769. Epub 2022 Feb 10. ABSTRACT Investigation of the synergistic and complementary effects is vital but difficult for...