Human metabolism of the semi-synthetic cannabinoids hexahydrocannabinol, hexahydrocannabiphorol and their acetates using hepatocytes and urine samples
Drug Test Anal. 2024 May 28. doi: 10.1002/dta.3740. Online ahead of print. ABSTRACT Hexahydrocannabinol (HHC), hexahydrocannabiphorol (HHCP) and their acetates, HHC-O and HHCP-O, respectively, are...
Effect of Cannabis sativa L. extracts, phytocannabinoids and their acetylated derivates on the SHSY-5Y neuroblastoma cells’ viability and caspases 3/7 activation
Biol Res. 2024 May 27;57(1):33. doi: 10.1186/s40659-024-00506-0. ABSTRACT BACKGROUND: There is a need for novel treatments for neuroblastoma, despite the emergence of new biological and...
Valorizing fungal diversity for the degradation of fluoroquinolones
Heliyon. 2024 May 9;10(10):e30611. doi: 10.1016/j.heliyon.2024.e30611. eCollection 2024 May 30. ABSTRACT Continued widespread use of antibiotics, especially fluoroquinolones, raises environmental concerns, as its driving bacterial...
Isolation of the Antifungal Compound Alliodorin from the Heartwood of Cordia elaeagnoides A. DC. and the In Silico Analysis of the Laccase
Plants (Basel). 2024 May 8;13(10):1294. doi: 10.3390/plants13101294. ABSTRACT Cordia elaeagnoides A. DC. is an endemic species of Mexico valued for its timber. Renowned for its...
Using In Silico Molecular Docking to Explain Differences in Receptor Binding Behavior of HHC and THCV Isomers: Revealing New Binding Modes
Pharmaceuticals (Basel). 2024 May 15;17(5):637. doi: 10.3390/ph17050637. ABSTRACT Even slight structural differences between phytocannabinoid isomers are usually enough to cause a change in their biological...
Evaluating the Metabolomic Profile and Anti-Pathogenic Properties of Cannabis Species
Metabolites. 2024 Apr 26;14(5):253. doi: 10.3390/metabo14050253. ABSTRACT The Cannabis species is one of the potent ancient medicinal plants acclaimed for its medicinal properties and recreational...
Modulation of Oxidative Stress and Neuroinflammation by Cannabidiol (CBD): Promising Targets for the Treatment of Alzheimer’s Disease
Curr Issues Mol Biol. 2024 May 6;46(5):4379-4402. doi: 10.3390/cimb46050266. ABSTRACT Alzheimer’s disease (AD) is a progressive neurodegenerative disease and the most common form of dementia...
Evaluating the Metabolomic Profile and Anti-Pathogenic Properties of Cannabis Species
Metabolites. 2024 Apr 26;14(5):253. doi: 10.3390/metabo14050253. ABSTRACT The Cannabis species is one of the potent ancient medicinal plants acclaimed for its medicinal properties and recreational...
The Potential of Cannabichromene (CBC) as a Therapeutic Agent
J Pharmacol Exp Ther. 2024 May 22:JPET-MR-2024-002166. doi: 10.1124/jpet.124.002166. Online ahead of print. ABSTRACT There is a growing interest in the use of medicinal plants...
Selected cannabis cultivars modulate glial activation: in vitro and in vivo studies
J Cannabis Res. 2024 May 22;6(1):25. doi: 10.1186/s42238-024-00232-0. ABSTRACT INTRODUCTION: Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system characterized by...
Selected cannabis cultivars modulate glial activation: in vitro and in vivo studies
J Cannabis Res. 2024 May 22;6(1):25. doi: 10.1186/s42238-024-00232-0. ABSTRACT INTRODUCTION: Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system characterized by...
Exploring the versatile roles of the endocannabinoid system and phytocannabinoids in modulating bacterial infections
Infect Immun. 2024 May 22:e0002024. doi: 10.1128/iai.00020-24. Online ahead of print. ABSTRACT The endocannabinoid system (ECS), initially identified for its role in maintaining homeostasis, particularly...
Inhibit or promote? Trade-off effect of dissolved organic matter on the laccase-mediator system
J Hazard Mater. 2024 May 14;473:134595. doi: 10.1016/j.jhazmat.2024.134595. Online ahead of print. ABSTRACT A biocatalytic system comprising fungal laccase and mediators can generate phenol radicals...
New insights into the involvement of serotonin and BDNF-TrkB signalling in cannabidiol’s antidepressant effect
Prog Neuropsychopharmacol Biol Psychiatry. 2024 May 16:111029. doi: 10.1016/j.pnpbp.2024.111029. Online ahead of print. ABSTRACT Cannabidiol (CBD) is a phytocannabinoid devoid of psychostimulant properties and is...
Anticancer effect of minor phytocannabinoids in preclinical models of multiple myeloma
Biofactors. 2024 May 17. doi: 10.1002/biof.2078. Online ahead of print. ABSTRACT Multiple myeloma (MM) is a blood cancer caused by uncontrolled growth of clonal plasmacells....