Chitin-glucan improves important pathophysiological features of irritable bowel syndrome
World J Gastroenterol. 2024 Apr 28;30(16):2258-2271. doi: 10.3748/wjg.v30.i16.2258. ABSTRACT BACKGROUND: Irritable bowel syndrome (IBS) is one of the most frequent and debilitating conditions leading to...
Cannabis Legalization and Resource Use for Ingestions by Young Children
Pediatrics. 2024 May 1:e2024065881. doi: 10.1542/peds.2024-065881. Online ahead of print. ABSTRACT OBJECTIVE: In conjunction with widening legalization, there has been a rapid rise in unintentional...
The CB1 negative allosteric modulator PSNCBAM-1 reduces ethanol self-administration via a nonspecific hypophagic effect
Pharmacol Biochem Behav. 2024 Apr 26:173776. doi: 10.1016/j.pbb.2024.173776. Online ahead of print. ABSTRACT Alcohol use disorder (AUD) affects >15 million people in the United States....
Neuromelanin levels in individuals with substance use disorders: A systematic review and meta-analysis
Neurosci Biobehav Rev. 2024 Apr 27;161:105690. doi: 10.1016/j.neubiorev.2024.105690. Online ahead of print. ABSTRACT Dopamine’s role in addiction has been extensively studied, revealing disruptions in its...
Discovery and development of macrocyclic peptide modulators of the cannabinoid 2 receptor
J Biol Chem. 2024 Apr 26:107330. doi: 10.1016/j.jbc.2024.107330. Online ahead of print. ABSTRACT The cannabinoid-type 2 receptor (CB2R), a G protein-coupled receptor (GPCR), is an...
Enzymatic Degradability of Diclofenac Ozonation Products: A Mechanistic Analysis
Chemosphere. 2024 Apr 25:142112. doi: 10.1016/j.chemosphere.2024.142112. Online ahead of print. ABSTRACT The treatment of waterborne micropollutants, such as diclofenac, presents a significant challenge to wastewater...
Using low-shear aerated and agitated bioreactor for producing two specific laccases by trametes versicolor cultures induced by 2,5-xylidine: Process development and economic analysis
Bioresour Technol. 2024 Apr 25:130737. doi: 10.1016/j.biortech.2024.130737. Online ahead of print. ABSTRACT Laccase isoforms from basidiomycetes exhibit a superior redox potential compared to commercially available...
Biodegradation of Trichloroethylene by Trametes versicolor and its Physiological Response to Contaminant Stress
Bull Environ Contam Toxicol. 2024 Apr 27;112(5):70. doi: 10.1007/s00128-024-03898-7. ABSTRACT Trichloroethylene (TCE) poses a potentially toxic threat to humans and the environment and widely exists...
Phytocannabinoids in neuromodulation: from omics to epigenetics
J Ethnopharmacol. 2024 Apr 25:118201. doi: 10.1016/j.jep.2024.118201. Online ahead of print. ABSTRACT BACKGROUND: Recent developments in metabolomics, transcriptomic and epigenetics open up new horizons regarding...
Placebo response in patients with Dravet syndrome: Post-hoc analysis of two clinical trials
Epilepsy Behav. 2024 Apr 26;156:109805. doi: 10.1016/j.yebeh.2024.109805. Online ahead of print. ABSTRACT OBJECTIVE: Dravet syndrome is a rare, early childhood-onset epileptic and developmental encephalopathy. Responses...
The Role of Medicinal Cannabis as an Emerging Therapy for Opioid Use Disorder
Pain Ther. 2024 Apr 27. doi: 10.1007/s40122-024-00599-1. Online ahead of print. ABSTRACT This narrative review explores current insights into the potential use of medicinal cannabis-related...
Effects of CB1 receptor negative allosteric modulator Org27569 on oxycodone withdrawal symptoms in mice
Psychopharmacology (Berl). 2024 Apr 27. doi: 10.1007/s00213-024-06591-z. Online ahead of print. ABSTRACT RATIONALE/OBJECTIVES: Targeting cannabinoid receptor type 1 (CB1R) has shown promise for treating opioid...
Comparative Analysis of Viromes Identified in Multiple Macrofungi
Viruses. 2024 Apr 12;16(4):597. doi: 10.3390/v16040597. ABSTRACT Macrofungi play important roles in the soil elemental cycle of terrestrial ecosystems. Fungal viruses are common in filamentous...
Trametes versicolor Laccase-Based Magnetic Inorganic-Protein Hybrid Nanobiocatalyst for Efficient Decolorization of Dyes in the Presence of Inhibitors
Materials (Basel). 2024 Apr 13;17(8):1790. doi: 10.3390/ma17081790. ABSTRACT In the present investigation, an ecofriendly magnetic inorganic-protein hybrid system-based enzyme immobilization was developed using partially purified...
Effectiveness of a universal, school-based, online programme for the prevention of anxiety, depression, and substance misuse among adolescents in Australia: 72-month outcomes from a cluster-randomised controlled trial
Lancet Digit Health. 2024 May;6(5):e334-e344. doi: 10.1016/S2589-7500(24)00046-3. ABSTRACT BACKGROUND: The CSC study found that the universal delivery of a school-based, online programme for the prevention...