Impaired cholesterol metabolism in the mouse model of cystic fibrosis. A preliminary study
PLoS One. 2021 Jan 7;16(1):e0245302. doi: 10.1371/journal.pone.0245302. eCollection 2021. ABSTRACT This study aims to investigate cholesterol metabolism in a mouse model with cystic fibrosis (CF)...
Efficient One-Step Biocatalytic Multienzyme Cascade Strategy for Direct Conversion of Phytosterol to C-17-Hydroxylated Steroids
Appl Environ Microbiol. 2021 Nov 24;87(24):e0032121. doi: 10.1128/AEM.00321-21. Epub 2021 Sep 29. ABSTRACT Steroidal 17-carbonyl reduction is crucial to the production of natural bioactive steroid...
Phytosterols and Cardiovascular Disease
Curr Atheroscler Rep. 2021 Sep 1;23(11):68. doi: 10.1007/s11883-021-00964-x. ABSTRACT PURPOSE OF REVIEW: Coronary heart disease is the leading cause of mortality worldwide. Elevated blood cholesterol...
Amelioration of Chlorpyrifos-Induced Toxicity in Brassica juncea L. by Combination of 24-Epibrassinolide and Plant-Growth-Promoting Rhizobacteria
Biomolecules. 2021 Jun 12;11(6):877. doi: 10.3390/biom11060877. ABSTRACT Pervasive use of chlorpyrifos (CP), an organophosphorus pesticide, has been proven to be fatal for plant growth, especially...
Monoallelic KIF1A-related disorders: a multicenter cross sectional study and systematic literature review
J Neurol. 2021 Sep 6. doi: 10.1007/s00415-021-10792-3. Online ahead of print. ABSTRACT BACKGROUND: Monoallelic variants in the KIF1A gene are associated with a large set...
Coenzyme Q10 and Cardiovascular Diseases
Antioxidants (Basel). 2021 Jun 3;10(6):906. doi: 10.3390/antiox10060906. ABSTRACT Coenzyme Q10 (CoQ10), which plays a key role in the electron transport chain by providing an adequate,...
Effect of supplementation with the reduced form of coenzyme Q10 on semen quality and antioxidant status in dogs with poor semen quality: Three case studies
J Vet Med Sci. 2021 Jul 2;83(7):1044-1049. doi: 10.1292/jvms.21-0174. Epub 2021 May 20. ABSTRACT Oxidative stress owing to an imbalance between reactive oxygen species and...
DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer
Nature. 2021 May;593(7860):586-590. doi: 10.1038/s41586-021-03539-7. Epub 2021 May 12. ABSTRACT Ferroptosis, a form of regulated cell death that is induced by excessive lipid peroxidation, is...
Therapeutic Potential and Immunomodulatory Role of Coenzyme Q10 and Its Analogues in Systemic Autoimmune Diseases
Antioxidants (Basel). 2021 Apr 13;10(4):600. doi: 10.3390/antiox10040600. ABSTRACT Coenzyme Q10 (CoQ10) is a mitochondrial electron carrier and a powerful lipophilic antioxidant located in membranes and...
Ubiquinol Supplementation Improves Gender-Dependent Cerebral Vasoreactivity and Ameliorates Chronic Inflammation and Endothelial Dysfunction in Patients with Mild Cognitive Impairment
Antioxidants (Basel). 2021 Jan 20;10(2):143. doi: 10.3390/antiox10020143. ABSTRACT Ubiquinol can protect endothelial cells from multiple mechanisms that cause endothelial damage and vascular dysfunction, thus contributing...
Anti-ageing effects of ubiquinone and ubiquinol in a senescence model of human dermal fibroblasts
Free Radic Biol Med. 2021 Mar;165:282-288. doi: 10.1016/j.freeradbiomed.2021.01.032. Epub 2021 Jan 19. ABSTRACT Coenzyme Q10 (CoQ10) is an endogenous lipophilic quinone found in equilibrium between...
Effects of Feeding Coenzyme Q10-Ubiquinol on Plasma Coenzyme Q10 Concentrations and Semen Quality in Stallions
J Equine Vet Sci. 2021 Jan;96:103303. doi: 10.1016/j.jevs.2020.103303. Epub 2020 Oct 15. ABSTRACT Although coenzyme Q10 (CoQ10) serves as an antioxidant and energy source for...
Coenzyme Q(10) Supplementation for the Reduction of Oxidative Stress: Clinical Implications in the Treatment of Chronic Diseases
Int J Mol Sci. 2020 Oct 23;21(21):7870. doi: 10.3390/ijms21217870. ABSTRACT Apart from its main function in the mitochondria as a key element in electron transport,...
The Protective Role of Bioactive Quinones in Stress-induced Senescence Phenotype of Endothelial Cells Exposed to Cigarette Smoke Extract
Antioxidants (Basel). 2020 Oct 16;9(10):1008. doi: 10.3390/antiox9101008. ABSTRACT Endothelial dysfunction represents the initial stage in atherosclerotic lesion development which occurs physiologically during aging, but external...
LC-MS/MS-QTOF Screening and Identification of Phenolic Compounds from Australian Grown Herbs and Their Antioxidant Potential
Antioxidants (Basel). 2021 Nov 5;10(11):1770. doi: 10.3390/antiox10111770. ABSTRACT Culinary spices and herbs have been used to impart a characteristic flavour and aroma in food due...