Therapeutic effect of Lactobacillus plantarum JS19 on mice with DSS-induced acute and chronic ulcerative colitis

J Sci Food Agric. 2022 Dec 27. doi: 10.1002/jsfa.12414. Online ahead of print.

ABSTRACT

BACKGROUND: Ulcerative colitis is associated with intestinal inflammation and dysbiosis. Previous studies have shown that probiotics are potential agents for treatment of inflammatory bowel disease (IBD). Jiang-shui is a traditional fermented vegetable which are rich in lactic acid bacteria (LAB). But the preventive effect of LAB in Jiang-shui on IBD is not yet fully understood.

RESULTS: In this study, a total of 38 LAB strains were isolated from Jiang-shui and Lactobacillus plantarum JS19 exhibited the strongest antioxidant activity among them. Our data indicate that oral administration of L. plantarum JS19 significantly inhibited body weight loss, colon shortening and damage as well as reduced the disease activity index score in the mic with DSS-induced colitis. In addition, L. plantarum JS19 also alleviated inflammatory responses and oxidative stress through reducing lipid peroxidation, TNF-α expression and myeloperoxidase activity and enhancing the antioxidant enzyme activity. Importantly, L. plantarum JS19 significantly rebalanced DSS-induced dysbiosis of gut microbiota.

CONCLUSION: L. plantarum JS19 may be used as a potential probiotic to prevent IBD, particularly ulcerative colitis. This article is protected by copyright. All rights reserved.

PMID:36573836 | DOI:10.1002/jsfa.12414