Curcumin attenuates LPS-induced sickness behavior and fever LPS-induced in rats by modulating Nrf2 activity
Neurosci Lett. 2022 May 11:136680. doi: 10.1016/j.neulet.2022.136680. Online ahead of print. ABSTRACT Lipopolysaccharide (LPS) is a potent inducer of inflammation, triggering behavioral changes and fever....
Platelet Activating Factor Receptor Exaggerates Microglia-Mediated Microenvironment by IL10-STAT3 Signaling: A Novel Potential Biomarker and Target for Diagnosis and Treatment of Alzheimer’s Disease
Front Aging Neurosci. 2022 Apr 28;14:856628. doi: 10.3389/fnagi.2022.856628. eCollection 2022. ABSTRACT BACKGROUND: Early diagnosis and effective intervention are the keys to delaying the progression of...
Curcumin Restrains Oxidative Stress of After Intracerebral Hemorrhage in Rat by Activating the Nrf2/HO-1 Pathway
Front Pharmacol. 2022 Apr 27;13:889226. doi: 10.3389/fphar.2022.889226. eCollection 2022. ABSTRACT Intracerebral hemorrhage (ICH), a severe hemorrhagic stroke, induces cerebral oxidative stress and severe secondary neurological...
Curcumin: reclaiming the lost ground against cancer resistance
Cancer Drug Resist. 2021 Jun 19;4(2):298-320. doi: 10.20517/cdr.2020.92. eCollection 2021. ABSTRACT Curcumin, a polyphenol, has a wide range of biological properties such as anticancer, antibacterial,...
Curcumin inhibits cerebral ischaemia-reperfusion injury and cell apoptosis in rats through the ERK-CHOP-caspase-11 pathway
Pharm Biol. 2022 Dec;60(1):854-861. doi: 10.1080/13880209.2022.2069271. ABSTRACT CONTEXT: Curcumin has a significant effect on cerebral ischaemia-reperfusion injury (CIRI). However, the underlying mechanism is less studied....
Targeting the Pathological Hallmarks of Alzheimer’s Disease Through Nanovesicle-aided Drug Delivery Approach
Curr Drug Metab. 2022 May 26. doi: 10.2174/1389200223666220526094802. Online ahead of print. ABSTRACT Introduction- Nanovesicle technology is making a huge contribution to the progress of...
Evaluation of curcumin as add-on therapy in patients with Parkinson’s disease: A pilot randomized, triple-blind, placebo-controlled trial
Clin Neurol Neurosurg. 2022 May 18;218:107300. doi: 10.1016/j.clineuro.2022.107300. Online ahead of print. ABSTRACT BACKGROUND AND OBJECTIVE: Preclinical studies suggest that curcumin might be a potential...
Curcumin-loaded human endometrial stem cells derived exosomes as an effective carrier to suppress alpha-synuclein aggregates in 6OHDA-induced Parkinson’s disease mouse model
Cell Tissue Bank. 2022 Jun 1. doi: 10.1007/s10561-022-10008-6. Online ahead of print. ABSTRACT Parkinson disease (PD) is considered as one of the most worldwide neurodegenerative...
Curcumin mitigates lipopolysaccharide-induced anxiety/depression-like behaviors, blood-brain barrier dysfunction and brain edema by decreasing cerebral oxidative stress in male rats
Neurosci Lett. 2022 May 26;782:136697. doi: 10.1016/j.neulet.2022.136697. Online ahead of print. ABSTRACT Oxidative stress is a well-known risk factor for the development of anxiety and...
Natural Therapeutics in Aid of Treating Alzheimer’s Disease: A Green Gateway Toward Ending Quest for Treating Neurological Disorders
Front Neurosci. 2022 May 16;16:884345. doi: 10.3389/fnins.2022.884345. eCollection 2022. ABSTRACT The current scientific community is facing a daunting challenge to unravel reliable natural compounds with...
Role of Curcumin in the Management of Schizophrenia: A Narrative Review
Indian J Psychol Med. 2022 Mar;44(2):107-113. doi: 10.1177/02537176211033331. Epub 2021 Sep 13. ABSTRACT Nutraceutical agents and food supplements are commonly used as treatment adjuncts in...
Phloroglucinol, a clinical-used antispasmodic, inhibits amyloid aggregation and degrades the pre-formed amyloid proteins
Int J Biol Macromol. 2022 Jun 3:S0141-8130(22)01202-8. doi: 10.1016/j.ijbiomac.2022.06.008. Online ahead of print. ABSTRACT Amyloid proteins, such as β-amyloid (Aβ) and α-synuclein (α-syn), could form...
Neuroprotective potential of curcuminoids in modulating Alzheimer’s Disease via multiple signaling pathways
Curr Med Chem. 2022 Jun 7. doi: 10.2174/0929867329666220607161328. Online ahead of print. ABSTRACT Alzheimer’s disease (AD) is a progressive and frequent neurodegenerative disease of elderly...
Synthesis and Anti-Neuroinflammatory Activity of 1,7-diphenyl-1,4-heptadien-3-ones in LPS-Stimulated BV2 Microglia Via Inhibiting NF-κB/MAPK Signaling Pathways
Molecules. 2022 May 31;27(11):3537. doi: 10.3390/molecules27113537. ABSTRACT A series of 1,7-diphenyl-1,4-heptadien-3-ones with various substituents (HO-, CH3O-, CH3-, Cl-) on the phenyl rings were synthesized and...
Application of curcumin nanoformulations in Alzheimer’s disease: prevention, diagnosis and treatment
Nutr Neurosci. 2022 Jun 11:1-16. doi: 10.1080/1028415X.2022.2084550. Online ahead of print. ABSTRACT Objectives: Alzheimer’s disease (AD) is a serious neurodegenerative disease. Although many therapeutic strategies...