Flavonoids as Potential Anti-Inflammatory Molecules: A Review
Molecules. 2022 May 2;27(9):2901. doi: 10.3390/molecules27092901. ABSTRACT Hydroxylated polyphenols, also called flavonoids, are richly present in vegetables, fruits, cereals, nuts, herbs, seeds, stems, and flowers...
Curcumin attenuates LPS-induced sickness behavior and fever LPS-induced in rats by modulating Nrf2 activity
Neurosci Lett. 2022 May 11:136680. doi: 10.1016/j.neulet.2022.136680. Online ahead of print. ABSTRACT Lipopolysaccharide (LPS) is a potent inducer of inflammation, triggering behavioral changes and fever....
Platelet Activating Factor Receptor Exaggerates Microglia-Mediated Microenvironment by IL10-STAT3 Signaling: A Novel Potential Biomarker and Target for Diagnosis and Treatment of Alzheimer’s Disease
Front Aging Neurosci. 2022 Apr 28;14:856628. doi: 10.3389/fnagi.2022.856628. eCollection 2022. ABSTRACT BACKGROUND: Early diagnosis and effective intervention are the keys to delaying the progression of...
Chocolate and Cocoa-Derived Biomolecules for Brain Cognition during Ageing
Antioxidants (Basel). 2022 Jul 12;11(7):1353. doi: 10.3390/antiox11071353. ABSTRACT Cognitive decline is a common problem in older individuals, often exacerbated by neurocognitive conditions, such as vascular...
Acute Effects of Cocoa Flavanols on Blood Pressure and Peripheral Vascular Reactivity in Type 2 Diabetes Mellitus and Essential Hypertension
Nutrients. 2022 Jun 28;14(13):2692. doi: 10.3390/nu14132692. ABSTRACT BACKGROUND: Type 2 diabetes mellitus (T2DM) is associated with a high risk of vascular complications. Interestingly, cocoa flavanols...
Assessing Variability in Vascular Response to Cocoa With Personal Devices: A Series of Double-Blind Randomized Crossover n-of-1 Trials
Front Nutr. 2022 Jun 13;9:886597. doi: 10.3389/fnut.2022.886597. eCollection 2022. ABSTRACT Controlled clinical intervention studies have demonstrated that cocoa flavanols (CF) can decrease blood pressure and...
Dietary Bioflavanol Supplementation Does Not Improve Cold-Induced Vasodilation in Healthy Adults
FASEB J. 2022 May;36 Suppl 1. doi: 10.1096/fasebj.2022.36.S1.R3395. ABSTRACT BACKGROUND: Cold-induced vasodilation (CIVD) is a cyclical rise in blood flow to glabrous skin that occurs...
Effect of cocoa flavanol supplementation for prevention of cardiovascular disease events: The COSMOS randomized clinical trial
Am J Clin Nutr. 2022 Mar 16:nqac055. doi: 10.1093/ajcn/nqac055. Online ahead of print. ABSTRACT BACKGROUND: Cocoa extract is a source of flavanols that favorably influence...
The Effect of Dietary Polyphenols on Vascular Health and Hypertension: Current Evidence and Mechanisms of Action
Nutrients. 2022 Jan 27;14(3):545. doi: 10.3390/nu14030545. ABSTRACT The aim of this review was to explore existing evidence from studies conducted on humans and summarize the...
Vasoactive Properties of a Cocoa Shell Extract: Mechanism of Action and Effect on Endothelial Dysfunction in Aged Rats
Antioxidants (Basel). 2022 Feb 21;11(2):429. doi: 10.3390/antiox11020429. ABSTRACT Cocoa has cardiovascular beneficial effects related to its content of antioxidant phytochemicals. Cocoa manufacturing produces large amounts...
Flavanol Consumption in Healthy Men Preserves Integrity of Immunological-Endothelial Barrier Cell Functions: Nutri(epi)genomic Analysis
Mol Nutr Food Res. 2022 Jan 30:e2100991. doi: 10.1002/mnfr.202100991. Online ahead of print. ABSTRACT SCOPE: While cocoa flavanol (CF) consumption improves cardiovascular risk biomarkers, molecular...
Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment -a randomized clinical trial
BMC Nutr. 2021 Nov 22;7(1):75. doi: 10.1186/s40795-021-00482-8. ABSTRACT BACKGROUND: Few randomized clinical trials have explored the health effects of bilberries in humans. The aim was...
Plant-Based Dietary Patterns, Plant Foods, and Age-Related Cognitive Decline
Adv Nutr. 2019 Nov 1;10(Suppl_4):S422-S436. doi: 10.1093/advances/nmz081. ABSTRACT The aging population is expanding, as is the prevalence of age-related cognitive decline (ARCD). Of the several...
The new aspects of clinical nutrition at Wilson disease: actuality and perspectives
Vopr Pitan. 2019;88(4):12-17. doi: 10.24411/0042-8833-2019-10036. Epub 2019 Jul 15. ABSTRACT Wilson disease is hereditary disorder of copper metabolism, based on defect of cooper excretion, which...
Beneficial Effects of Dark Chocolate for Episodic Memory in Healthy Young Adults: A Parallel-Groups Acute Intervention with a White Chocolate Control
Nutrients. 2020 Feb 14;12(2):483. doi: 10.3390/nu12020483. ABSTRACT There is good evidence that cocoa flavonoids can acutely improve cognitive function in humans, possibly via mechanisms such...