The clinical relevance of omega-3 fatty acids in the management of hypertriglyceridemia
Lipids Health Dis. 2016 Jul 22;15(1):118. doi: 10.1186/s12944-016-0286-4. ABSTRACT Hypertriglyceridemia (triglycerides > 150 mg/dL) affects ~25 % of the United States (US) population and is...
Bioavailability of tomato polyphenols is enhanced by processing and fat addition: Evidence from a randomized feeding trial
Mol Nutr Food Res. 2016 Jul;60(7):1578-89. doi: 10.1002/mnfr.201500820. Epub 2016 May 9. ABSTRACT SCOPE: Tomato contains a variety of phenolics associated with health-promoting properties. However,...
Nanoemulsifying drug delivery system to improve the bioavailability of piroxicam
Pharm Dev Technol. 2017 May;22(3):445-456. doi: 10.1080/10837450.2016.1231810. Epub 2016 Oct 25. ABSTRACT OBJECTIVE: The aim of this study is to develop and characterize self-nanoemulsifying drug...
Microemulsions containing long-chain oil ethyl oleate improve the oral bioavailability of piroxicam by increasing drug solubility and lymphatic transportation simultaneously
Int J Pharm. 2016 Sep 25;511(2):709-18. doi: 10.1016/j.ijpharm.2016.07.061. Epub 2016 Jul 26. ABSTRACT Drug solubility and lymphatic transport enhancements are two main pathways to improve...
Dietary intake of n-3 PUFAs modifies the absorption, distribution and bioavailability of fatty acids in the mouse gastrointestinal tract
Lipids Health Dis. 2017 Jan 17;16(1):10. doi: 10.1186/s12944-016-0399-9. ABSTRACT BACKGROUND: Dietary polyunsaturated fatty acids (PUFAs), especially n-3 PUFAs, are important for human health. The intestinal...
Wax Ester Rich Oil From The Marine Crustacean, Calanus finmarchicus, is a Bioavailable Source of EPA and DHA for Human Consumption
Lipids. 2016 Oct;51(10):1137-1144. doi: 10.1007/s11745-016-4189-y. Epub 2016 Sep 7. ABSTRACT Oil from the marine copepod, Calanus finmarchicus, which contains >86 % of fatty acids present...
The influence of lipid droplet size on the oral bioavailability of vitamin D2 encapsulated in emulsions: an in vitro and in vivo study
Food Funct. 2017 Feb 22;8(2):767-777. doi: 10.1039/c6fo01565d. ABSTRACT Vitamin D deficiency is prevalent in some populations leading to adverse health effects, and therefore there is...
Effects of Food on the Pharmacokinetics of Omega-3-Carboxylic Acids in Healthy Japanese Male Subjects: A Phase I, Randomized, Open-label, Three-period, Crossover Trial
J Atheroscler Thromb. 2017 Sep 1;24(9):980-987. doi: 10.5551/jat.38737. Epub 2017 Mar 24. ABSTRACT AIMS: Omega-3-carboxylic acids (OM3-CA) contain omega-3 free fatty acids, such as eicosapentaenoic...
A Novel ω-3 Acid Ethyl Ester Formulation Incorporating Advanced Lipid TechnologiesTM (ALT®) Improves Docosahexaenoic Acid and Eicosapentaenoic Acid Bioavailability Compared with Lovaza®
Clin Ther. 2017 Mar;39(3):581-591. doi: 10.1016/j.clinthera.2017.01.020. Epub 2017 Feb 9. ABSTRACT PURPOSE: The US Food and Drug Administration has approved several highly purified ω-3 fatty...
Modeling the dose effects of soybean oil in salad dressing on carotenoid and fat-soluble vitamin bioavailability in salad vegetables
Am J Clin Nutr. 2017 Oct;106(4):1041-1051. doi: 10.3945/ajcn.117.153635. Epub 2017 Aug 16. ABSTRACT Background: Previously, we showed that vegetable oil is necessary for carotenoid absorption...
Minimal food effect for eicosapentaenoic acid and docosahexaenoic acid bioavailability from omega-3-acid ethyl esters with an Advanced Lipid TechnologiesTM (ALT®)-based formulation
J Clin Lipidol. 2017 Mar-Apr;11(2):394-405. doi: 10.1016/j.jacl.2017.01.017. Epub 2017 Feb 9. ABSTRACT BACKGROUND: The absorption of eicosapentaenoic acid (EPA; 20:5n-3) and docosahexaenoic acid (DHA; 22:6n-3)...
A novel self-micro-emulsifying delivery system (SMEDS) formulation significantly improves the fasting absorption of EPA and DHA from a single dose of an omega-3 ethyl ester concentrate
Lipids Health Dis. 2017 Oct 16;16(1):204. doi: 10.1186/s12944-017-0589-0. ABSTRACT BACKGROUND: Absorption of EPA and DHA from Omega-3-acid ethyl ester (EE) concentrate supplements occurs most efficiently...
Changes in Bioavailability of Omega-3 (DHA) through Alpha-Tocopheryl Phosphate Mixture (TPM) after Oral Administration in Rats
Nutrients. 2017 Sep 20;9(9):1042. doi: 10.3390/nu9091042. ABSTRACT Benefits of Omega-3 Docosahexaenoic acid (DHA) supplements are hindered by their poor solubility and bioavailability. This study investigated...
Relative levels of dietary EPA and DHA impact gastric oxidation and essential fatty acid uptake
J Nutr Biochem. 2018 May;55:68-75. doi: 10.1016/j.jnutbio.2017.11.007. Epub 2017 Dec 10. ABSTRACT Previous research showed that increasing the proportion of docosahexaenoic acid (DHA) in marine...
Oral Delivery of Highly Lipophilic, Poorly Water-Soluble Drugs: Self-Emulsifying Drug Delivery Systems to Improve Oral Absorption and Enable High-Dose Toxicology Studies of a Cholesteryl Ester Transfer Protein Inhibitor in Preclinical Species
J Pharm Sci. 2018 May;107(5):1352-1360. doi: 10.1016/j.xphs.2018.01.003. Epub 2018 Jan 6. ABSTRACT BMS-A is an inhibitor of cholesteryl ester transfer protein and is a highly...