A Novel ω-3 Acid Ethyl Ester Formulation Incorporating Advanced Lipid TechnologiesTM (ALT®) Improves Docosahexaenoic Acid and Eicosapentaenoic Acid Bioavailability Compared with Lovaza®
Clin Ther. 2017 Mar;39(3):581-591. doi: 10.1016/j.clinthera.2017.01.020. Epub 2017 Feb 9. ABSTRACT PURPOSE: The US Food and Drug Administration has approved several highly purified ω-3 fatty...
Modeling the dose effects of soybean oil in salad dressing on carotenoid and fat-soluble vitamin bioavailability in salad vegetables
Am J Clin Nutr. 2017 Oct;106(4):1041-1051. doi: 10.3945/ajcn.117.153635. Epub 2017 Aug 16. ABSTRACT Background: Previously, we showed that vegetable oil is necessary for carotenoid absorption...
Minimal food effect for eicosapentaenoic acid and docosahexaenoic acid bioavailability from omega-3-acid ethyl esters with an Advanced Lipid TechnologiesTM (ALT®)-based formulation
J Clin Lipidol. 2017 Mar-Apr;11(2):394-405. doi: 10.1016/j.jacl.2017.01.017. Epub 2017 Feb 9. ABSTRACT BACKGROUND: The absorption of eicosapentaenoic acid (EPA; 20:5n-3) and docosahexaenoic acid (DHA; 22:6n-3)...
A novel self-micro-emulsifying delivery system (SMEDS) formulation significantly improves the fasting absorption of EPA and DHA from a single dose of an omega-3 ethyl ester concentrate
Lipids Health Dis. 2017 Oct 16;16(1):204. doi: 10.1186/s12944-017-0589-0. ABSTRACT BACKGROUND: Absorption of EPA and DHA from Omega-3-acid ethyl ester (EE) concentrate supplements occurs most efficiently...
Changes in Bioavailability of Omega-3 (DHA) through Alpha-Tocopheryl Phosphate Mixture (TPM) after Oral Administration in Rats
Nutrients. 2017 Sep 20;9(9):1042. doi: 10.3390/nu9091042. ABSTRACT Benefits of Omega-3 Docosahexaenoic acid (DHA) supplements are hindered by their poor solubility and bioavailability. This study investigated...
Oral Delivery of Highly Lipophilic, Poorly Water-Soluble Drugs: Self-Emulsifying Drug Delivery Systems to Improve Oral Absorption and Enable High-Dose Toxicology Studies of a Cholesteryl Ester Transfer Protein Inhibitor in Preclinical Species
J Pharm Sci. 2018 May;107(5):1352-1360. doi: 10.1016/j.xphs.2018.01.003. Epub 2018 Jan 6. ABSTRACT BMS-A is an inhibitor of cholesteryl ester transfer protein and is a highly...
Correlating in Vitro Solubilization and Supersaturation Profiles with in Vivo Exposure for Lipid Based Formulations of the CETP Inhibitor CP-532,623
Mol Pharm. 2017 Dec 4;14(12):4525-4538. doi: 10.1021/acs.molpharmaceut.7b00660. Epub 2017 Nov 9. ABSTRACT Lipid based formulations (LBFs) are a promising formulation strategy for many poorly water-soluble...
Relative levels of dietary EPA and DHA impact gastric oxidation and essential fatty acid uptake
J Nutr Biochem. 2018 May;55:68-75. doi: 10.1016/j.jnutbio.2017.11.007. Epub 2017 Dec 10. ABSTRACT Previous research showed that increasing the proportion of docosahexaenoic acid (DHA) in marine...
Absorption rate of krill oil and fish oil in blood and brain of rats
Lipids Health Dis. 2018 Jul 18;17(1):162. doi: 10.1186/s12944-018-0812-7. ABSTRACT BACKGROUND: Krill (Euphausia superba) is a small marine crustacean with a lipid content. The mechanism of...
Supersaturable Self-Emulsifying Drug Delivery System of Krill Oil with Improved Oral Absorption and Hypotriglyceridemic Function
J Agric Food Chem. 2018 May 30;66(21):5352-5358. doi: 10.1021/acs.jafc.8b00693. Epub 2018 May 21. ABSTRACT This study aimed to develop a supersaturable self-emulsifying drug delivery system...
Bioavailability and Safety of Nutrients from the Microalgae Chlorella vulgaris, Nannochloropsis oceanica and Phaeodactylum tricornutum in C57BL/6 Mice
Nutrients. 2018 Jul 26;10(8):965. doi: 10.3390/nu10080965. ABSTRACT Microalgae are rich in macronutrients and therefore, they have been proposed as a potential future food source preserving...
Intrinsic and Extrinsic Factors Impacting Absorption, Metabolism, and Health Effects of Dietary Carotenoids
Adv Nutr. 2018 Jul 1;9(4):465-492. doi: 10.1093/advances/nmy025. ABSTRACT Carotenoids are orange, yellow, and red lipophilic pigments present in many fruit and vegetables, as well as...
Effects of a Self-micro-emulsifying Delivery System Formulation Versus a Standard ω-3 Acid Ethyl Ester Product on the Bioavailability of Eicosapentaenoic Acid and Docosahexaenoic Acid: A Study in Healthy Men and Women in a Fasted State
Clin Ther. 2018 Dec;40(12):2065-2076. doi: 10.1016/j.clinthera.2018.10.014. Epub 2018 Nov 16. ABSTRACT PURPOSE: Intakes of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are associated with several...
Effect of linolenic acid on bioavailability of cadmium in eutrophic water
Wei Sheng Yan Jiu. 2018 Jul;47(4):644-661. ABSTRACT OBJECTIVE: To investigate the bioavailability of heavy metal cadmium on planktonic algae under the condition of containing linolenic...
Bioavailability of docosahexaenoic acid 22:6(n-3) from enantiopure triacylglycerols and their regioisomeric counterpart in rats
Food Chem. 2019 Jun 15;283:381-389. doi: 10.1016/j.foodchem.2018.12.130. Epub 2019 Jan 14. ABSTRACT Lack of synthetic enantiospecific triacylglycerols (TAGs) has hindered our understanding of the impact...