Dietary cocoa ameliorates obesity-related inflammation in high fat-fed mice
Eur J Nutr. 2014 Feb;53(1):149-58. doi: 10.1007/s00394-013-0510-1. Epub 2013 Mar 15. ABSTRACT PURPOSE: To investigate the effect of cocoa powder supplementation on obesity-related inflammation in...
Potential implications of dose and diet for the effects of cocoa flavanols on cardiometabolic function
J Agric Food Chem. 2015 Nov 18;63(45):9942-7. doi: 10.1021/acs.jafc.5b01492. Epub 2015 Jul 28. ABSTRACT The metabolic syndrome is a pathological state whereby cardiovascular and metabolic...
Natural antioxidant ice cream acutely reduces oxidative stress and improves vascular function and physical performance in healthy individuals
Nutrition. 2017 Jan;33:225-233. doi: 10.1016/j.nut.2016.07.008. Epub 2016 Jul 26. ABSTRACT OBJECTIVE: The formation of reactive oxygen species (ROS) contributes to the pathogenesis and progression of...
The prothrombotic state associated with obesity-induced hypertension is reduced by cocoa and its main flavanols
Food Funct. 2016 Dec 7;7(12):4880-4888. doi: 10.1039/c6fo01165a. ABSTRACT BACKGROUND: Little is known about the effects of cocoa and its main flavanols on the prothrombotic state...
Effects of Dark Chocolate and Almonds on Cardiovascular Risk Factors in Overweight and Obese Individuals: A Randomized Controlled-Feeding Trial
J Am Heart Assoc. 2017 Nov 29;6(12):e005162. doi: 10.1161/JAHA.116.005162. ABSTRACT BACKGROUND: Consumption of almonds or dark chocolate and cocoa has favorable effects on markers of...
Natural cocoa inhibits maternal hypercholesterolaemia-induced atherogenesis in rabbit pups
Cardiovasc J Afr. 2019 Jul/Aug 23;30(4):208-215. doi: 10.5830/CVJA-2019-019. Epub 2019 May 24. ABSTRACT Atherosclerosis begins during foetal development and is enhanced by maternal hypercholesterolaemia during...
Acute Soy Supplementation Improves 20-km Time Trial Performance, Power, and Speed
Med Sci Sports Exerc. 2020 Jan;52(1):170-177. doi: 10.1249/MSS.0000000000002102. ABSTRACT INTRODUCTION: Isoflavones, a chemical class of phytoestrogens found in soybeans and soy products, may have biological...
Effect of cocoa powder on hypertension and antioxidant status in uninephrectomized hypertensive rats
Vet World. 2019 Apr;13(4):695-705. doi: 10.14202/vetworld.2020.695-705. Epub 2020 Apr 16. ABSTRACT BACKGROUND AND AIM: High salt diet and uninephrectomy are associated with high blood pressure...
Protective effects of icariin on dorsal random skin flap survival: An experimental study
Eur J Pharmacol. 2019 Oct 15;861:172600. doi: 10.1016/j.ejphar.2019.172600. Epub 2019 Aug 8. ABSTRACT This study was performed to examine the protective effects of icariin (ICA)...
Icariin promotes angiogenesis in glucocorticoid-induced osteonecrosis of femoral heads: In vitro and in vivo studies
J Cell Mol Med. 2019 Nov;23(11):7320-7330. doi: 10.1111/jcmm.14589. Epub 2019 Sep 10. ABSTRACT The injury and dysfunction of the femoral head microvascular endothelial cells are...
Inhibition of airway remodeling and inflammatory response by Icariin in asthma
BMC Complement Altern Med. 2019 Nov 19;19(1):316. doi: 10.1186/s12906-019-2743-x. ABSTRACT BACKGROUND: Icariin (ICA) is the major active ingredient extracted from Chinese herbal medicine Epimedium, which...
Icariside II affects hippocampal neuron axon regeneration and improves learning and memory in a chronic cerebral hypoperfusion rat model
Int J Clin Exp Pathol. 2019 Mar 1;12(3):826-834. eCollection 2019. ABSTRACT Chronic cerebral hypoperfusion (CCH) is a basic pathological process that is comorbid with brain...
Icariin ameliorates endothelial dysfunction in type 1 diabetic rats by suppressing ER stress via the PPARalpha/Sirt1/AMPKalpha pathway
J Cell Physiol. 2021 Mar;236(3):1889-1902. doi: 10.1002/jcp.29972. Epub 2020 Aug 7. ABSTRACT Icariin (ICA), as a flavonoid glycoside, is associated with the improvement of vascular...
Preliminary study of icariin indicating prevention of steroid-induced osteonecrosis of femoral head by regulating abnormal expression of miRNA-335 and protecting the functions of bone microvascular endothelial cells in rats
Gene. 2021 Jan 15;766:145128. doi: 10.1016/j.gene.2020.145128. Epub 2020 Sep 7. ABSTRACT BACKGROUND: The pathogenesis of osteonecrosis of the femoral head (ONFH) is unclear. Our previous...
Sex hormone-like Effects of Icariin on T-cells immune modulation in spontaneously hypertensive rats
J Ethnopharmacol. 2021 Apr 6;269:113717. doi: 10.1016/j.jep.2020.113717. Epub 2020 Dec 24. ABSTRACT ETHNOPHARMACOLOGICAL RELEVANCE: Epimedium brevicornu Maxim as a Chinese herb, is recommended for the...