Non-linear Mendelian randomization analyses support a role for vitamin D deficiency in cardiovascular disease risk
Eur Heart J. 2021 Dec 5:ehab809. doi: 10.1093/eurheartj/ehab809. Online ahead of print. ABSTRACT AIMS: Low vitamin D status is associated with a higher risk for...
The Inhibitory Effect of Curcumin Derivative J147 on Melanogenesis and Melanosome Transport by Facilitating ERK-Mediated MITF Degradation
Front Pharmacol. 2021 Nov 23;12:783730. doi: 10.3389/fphar.2021.783730. eCollection 2021. ABSTRACT The therapeutic use of curcumin and chemically modified curcumin (CMC) for suppressing melanogenesis and tyrosinase...
Flavonoids: Classification, Function, and Molecular Mechanisms Involved in Bone Remodelling
Front Endocrinol (Lausanne). 2021 Nov 23;12:779638. doi: 10.3389/fendo.2021.779638. eCollection 2021. ABSTRACT Flavonoids are polyphenolic compounds spotted in various fruits, vegetables, barks, tea plants, and stems...
The Combination of beta-Asarone and Icariin Inhibits Amyloid-beta and Reverses Cognitive Deficits by Promoting Mitophagy in Models of Alzheimer’s Disease
Oxid Med Cell Longev. 2021 Nov 30;2021:7158444. doi: 10.1155/2021/7158444. eCollection 2021. ABSTRACT β-Asarone is the main constituent of Acorus tatarinowii Schott and exhibits important effects...
Evaluation and Characterization of Curcumin-beta-Cyclodextrin and Cyclodextrin-Based Nanosponge Inclusion Complexation
Polymers (Basel). 2021 Nov 24;13(23):4073. doi: 10.3390/polym13234073. ABSTRACT Cyclodextrin polymers and cyclodextrin-based nanosponges have been widely investigated for increasing drug bioavailability. This study examined curcumin’s...
Design of Hybrid Polymeric-Lipid Nanoparticles Using Curcumin as a Model: Preparation, Characterization, and In Vitro Evaluation of Demethoxycurcumin and Bisdemethoxycurcumin-Loaded Nanoparticles
Polymers (Basel). 2021 Nov 30;13(23):4207. doi: 10.3390/polym13234207. ABSTRACT Polymeric lipid hybrid nanoparticles (PLHNs) are the new generation of drug delivery systems that has emerged as...
The Multifaceted Role of Curcumin in Advanced Nanocurcumin Form in the Treatment and Management of Chronic Disorders
Molecules. 2021 Nov 24;26(23):7109. doi: 10.3390/molecules26237109. ABSTRACT Curcumin is the primary polyphenol in turmeric’s curcuminoid class. It has a wide range of therapeutic applications, such...
Effects of curcumin on neurobehavior and oxidative stress in hippocampus of rats exposed to manganese
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2021 Nov 20;39(11):801-807. doi: 10.3760/cma.j.cn121094-20201126-00651. ABSTRACT Objective: To establish the animal model of subchronic manganism,...
A new perspective on cholesterol in pediatric health: Association of vitamin D metabolism, respiratory diseases, and mental health problems
Clin Exp Pediatr. 2021 Dec 9. doi: 10.3345/cep.2020.00934. Online ahead of print. ABSTRACT Cholesterol, the main structural molecule of cell membranes, is involved in essential...
Vitamin D and COVID-19: where are we now?
Postgrad Med. 2021 Dec 9. doi: 10.1080/00325481.2021.2017647. Online ahead of print. ABSTRACT The pandemic caused by the SARS-CoV-2 virus has triggered great interest in the...
Cinnamon and Eucalyptus Oils Suppress the Inflammation Induced by Lipopolysaccharide In Vivo
Molecules. 2021 Dec 6;26(23):7410. doi: 10.3390/molecules26237410. ABSTRACT Inflammation caused by bacterial lipopolysaccharide (LPS) disrupts epithelial homeostasis and threatens both human and animal health. Therefore, the...
Microwave-Assisted Extraction of Phenolic Compounds from Spent Coffee Grounds. Process Optimization Applying Design of Experiments
Molecules. 2021 Dec 2;26(23):7320. doi: 10.3390/molecules26237320. ABSTRACT In this study, sustainable technology microwave-assisted extraction (MAE) in association with green solvents was applied to recover phenolic...
Hexahydrocurcumin ameliorates hypertensive and vascular remodeling in L-NAME-induced rats
Biochim Biophys Acta Mol Basis Dis. 2021 Dec 6:166317. doi: 10.1016/j.bbadis.2021.166317. Online ahead of print. ABSTRACT Hexahydrocurcumin (HHC), a major metabolite of curcumin, possesses several...
Curcumin biosynthesis from ferulic acid by engineered Saccharomyces cerevisiae
Biotechnol J. 2021 Dec 9:e2100400. doi: 10.1002/biot.202100400. Online ahead of print. ABSTRACT BACKGROUND AND GOAL: Curcumin is a polyphenolic compound found in Curcuma longa. This...
A Novel Curcumin-Based Drug Powder Inhalation Medicine for Chronic Obstructive Pulmonary Disease
Bioinorg Chem Appl. 2021 Nov 29;2021:8001787. doi: 10.1155/2021/8001787. eCollection 2021. ABSTRACT The dry powder inhaler is a new form of drug delivery that is widely...