Strategies to improve bioavailability of omega-3 fatty acids from ethyl ester concentrates
Curr Opin Clin Nutr Metab Care. 2019 Mar;22(2):116-123. doi: 10.1097/MCO.0000000000000537. ABSTRACT PURPOSE OF REVIEW: To describe recent strategies that have been developed to enhance absorption...
Bioavailability of docosahexaenoic acid 22:6(n-3) from enantiopure triacylglycerols and their regioisomeric counterpart in rats
Food Chem. 2019 Jun 15;283:381-389. doi: 10.1016/j.foodchem.2018.12.130. Epub 2019 Jan 14. ABSTRACT Lack of synthetic enantiospecific triacylglycerols (TAGs) has hindered our understanding of the impact...
Thermal stability and bioavailability of inclusion complexes of perilla oil with γ-cyclodextrin
Food Chem. 2019 Oct 1;294:56-59. doi: 10.1016/j.foodchem.2019.04.093. Epub 2019 Apr 25. ABSTRACT Perilla oil is abundant in α-linolenic acid, which is metabolized to long-chain n-3...
In vitro lipolysis and lymphatic absorption of n-3 long-chain PUFA in the rat: influence of the molecular lipid species as carrier
Br J Nutr. 2019 Sep 28;122(6):639-647. doi: 10.1017/S0007114519001491. ABSTRACT The aim of this work was to study the bioavailability of fatty acids (FA), focusing on...
A self-emulsifying Omega-3 ethyl ester formulation (AquaCelle) significantly improves eicosapentaenoic and docosahexaenoic acid bioavailability in healthy adults
Eur J Nutr. 2020 Sep;59(6):2729-2737. doi: 10.1007/s00394-019-02118-x. Epub 2019 Oct 21. ABSTRACT PURPOSE: Application of intelligent formulation design has the ability to address the poor...
Oral administration of a synthetic vinyl-ether plasmalogen normalizes open field activity in a mouse model of rhizomelic chondrodysplasia punctata
Dis Model Mech. 2020 Jan 24;13(1):dmm042499. doi: 10.1242/dmm.042499. ABSTRACT Rhizomelic chondrodysplasia punctata (RCDP) is a rare genetic disorder caused by mutations in peroxisomal genes essential...
Microencapsulated Tuna Oil Results in Higher Absorption of DHA in Toddlers
Nutrients. 2020 Jan 18;12(1):248. doi: 10.3390/nu12010248. ABSTRACT : Docosahexaenoic acid (DHA) is an essential component for brain and visual acuity development during foetal and early...
Intestinal bioavailability of n-3 long-chain polyunsaturated fatty acids influenced by the supramolecular form of phospholipids
Food Funct. 2020 Feb 26;11(2):1721-1728. doi: 10.1039/c9fo02953b. ABSTRACT The aim of this work was to study the bioavailability of n-3 long-chain polyunsaturated fatty acids (n-3...
Effects of a plant-based fatty acid supplement and a powdered fruit, vegetable and berry juice concentrate on omega-3-indices and serum micronutrient concentrations in healthy subjects
Int J Food Sci Nutr. 2020 Sep;71(6):769-780. doi: 10.1080/09637486.2020.1725960. Epub 2020 Feb 17. ABSTRACT The major aim of this controlled, randomised, open-labelled, parallel-grouped, clinical trial...
Monoacylglycerol Form of Omega-3s Improves Its Bioavailability in Humans Compared to Other Forms
Nutrients. 2020 Apr 7;12(4):1014. doi: 10.3390/nu12041014. ABSTRACT Numerous benefits are attributed to omega-3 fatty acids (OM3) especially in cardiovascular health. However, bioavailability and clinical efficacy...
Pharmacokinetics and bioavailability of hydroxytyrosol are dependent on the food matrix in humans
Eur J Nutr. 2021 Mar;60(2):905-915. doi: 10.1007/s00394-020-02295-0. Epub 2020 Jun 10. ABSTRACT PURPOSE: Several studies have demonstrated the properties of hydroxytyrosol, a phenolic compound present...
Chase Dosing of Lipid Formulations to Enhance Oral Bioavailability of Nilotinib in Rats
Pharm Res. 2020 Jun 10;37(7):124. doi: 10.1007/s11095-020-02841-9. ABSTRACT PURPOSE: Lipid-based formulations (LBF) have shown oral bioavailability enhancement of lipophilic drugs, but not necessarily in the...
Novel Biphasic Lipolysis Method To Predict in Vivo Performance of Lipid-Based Formulations
Mol Pharm. 2020 Sep 8;17(9):3342-3352. doi: 10.1021/acs.molpharmaceut.0c00427. Epub 2020 Aug 21. ABSTRACT The absence of an intestinal absorption sink is a significant weakness of standard...
In vitro dissolution behaviour and absorption in humans of a novel mixed l-lysine salt formulation of EPA and DHA
Prostaglandins Leukot Essent Fatty Acids. 2021 Jan;164:102232. doi: 10.1016/j.plefa.2020.102232. Epub 2020 Dec 19. ABSTRACT INTRODUCTION: Supplements with eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are...
Natural sesame oil is superior to pre-digested lipid formulations and purified triglycerides in promoting the intestinal lymphatic transport and systemic bioavailability of cannabidiol
Eur J Pharm Biopharm. 2021 May;162:43-49. doi: 10.1016/j.ejpb.2021.02.013. Epub 2021 Mar 5. ABSTRACT Lipid-based formulations play a significant role in oral delivery of lipophilic drugs....