Specialized Pro-Resolving Mediators in Neuroinflammation: Overview of Studies and Perspectives of Clinical Applications
Molecules. 2022 Jul 28;27(15):4836. doi: 10.3390/molecules27154836. ABSTRACT Specialized pro-resolving mediators (SPMs) are lipid mediators derived from poly-unsaturated fatty acids (PUFAs) which have been demonstrated to...
Dysregulation of Subcutaneous White Adipose Tissue Inflammatory Environment Modelling in Non-Insulin Resistant Obesity and Responses to Omega-3 Fatty Acids – A Double Blind, Randomised Clinical Trial
Front Immunol. 2022 Jul 25;13:922654. doi: 10.3389/fimmu.2022.922654. eCollection 2022. ABSTRACT BACKGROUND: Obesity is associated with enhanced lipid accumulation and the expansion of adipose tissue accompanied...
Big Fish or No Fish; Eicosapentaenoic Acid and Cardiovascular Disease
Endocrinol Metab Clin North Am. 2022 Sep;51(3):625-633. doi: 10.1016/j.ecl.2022.02.012. Epub 2022 Jul 6. ABSTRACT Benefits of omega 3 fatty acids for cardiovascular and other diseases...
Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
J Vis Exp. 2022 Jul 27;(185). doi: 10.3791/63995. ABSTRACT The low aqueous solubility of many drugs reduces their bioavailability in the blood. Oils have been...
Supplemental Marine ω-3 Fatty Acids Did Not Prevent New Dry Eye Disease
JAMA. 2022 Aug 16;328(7):610. doi: 10.1001/jama.2022.13122. NO ABSTRACT PMID:35972498 | DOI:10.1001/jama.2022.13122...
The effects of maternal fish oil supplementation rich in n-3 PUFA on offspring-broiler growth performance, body composition and bone microstructure
PLoS One. 2022 Aug 16;17(8):e0273025. doi: 10.1371/journal.pone.0273025. eCollection 2022. ABSTRACT This study evaluated the effects of maternal fish oil supplementation rich in n-3 PUFA on...
High fat diets induce early changes in gut microbiota that may serve as markers of ulterior altered physiological and biochemical parameters related to metabolic syndrome. Effect of virgin olive oil in comparison to butter
PLoS One. 2022 Aug 16;17(8):e0271634. doi: 10.1371/journal.pone.0271634. eCollection 2022. ABSTRACT Butter and virgin olive oil (EVOO) are two fats differing in their degree of saturation...
Curcumin and Quercetin-Loaded Lipid Nanocarriers: Development of Omega-3 Mucoadhesive Nanoemulsions for Intranasal Administration
Nanomaterials (Basel). 2022 Mar 25;12(7):1073. doi: 10.3390/nano12071073. ABSTRACT Curcumin (CUR) and quercetin (QU) are potential compounds for treatment of brain diseases such as neurodegenerative diseases...
L-arginine in Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like Episodes: A Systematic Review
Neurology. 2022 Apr 15:10.1212/WNL.0000000000200299. doi: 10.1212/WNL.0000000000200299. Online ahead of print. ABSTRACT OBJECTIVE: Stroke management in the context of primary mitochondrial disease is clinically challenging and...
A novel process driving Alzheimer’s disease validated in a mouse model: Therapeutic potential
Alzheimers Dement (N Y). 2022 Apr 5;8(1):e12274. doi: 10.1002/trc2.12274. eCollection 2022. ABSTRACT INTRODUCTION: The neuronal mechanism driving Alzheimer’s disease (AD) is incompletely understood. METHODS: Immunohistochemistry,...
Coumarin derivatives as inhibitors of d-amino acid oxidase and monoamine oxidase
Bioorg Chem. 2022 Apr 6;123:105791. doi: 10.1016/j.bioorg.2022.105791. Online ahead of print. ABSTRACT d-Amino acid oxidase (DAAO) oxidises d-amino acids to ultimately produce the corresponding α-keto...
Antidepressant Potential of Quercetin and its Glycoside Derivatives: A Comprehensive Review and Update
Front Pharmacol. 2022 Apr 8;13:865376. doi: 10.3389/fphar.2022.865376. eCollection 2022. ABSTRACT Depression is a global health problem with growing prevalence rates and serious impacts on the...
Application of Sol-Gels Modified with Natural Plants Extracts as Stationary Phases in Open-Tubular Capillary Electrochromatography
Gels. 2022 Mar 22;8(4):198. doi: 10.3390/gels8040198. ABSTRACT Ethanol extracts of three widely growing plants were added to silica sol-gel solutions, which were subsequently applied as...
Therapeutic role of curcumin in adult neurogenesis for management of psychiatric and neurological disorders: a scientometric study to an in-depth review
Crit Rev Food Sci Nutr. 2022 Apr 28:1-13. doi: 10.1080/10408398.2022.2067827. Online ahead of print. ABSTRACT Aberrant neurogenesis is a major factor in psychiatric and neurological...
Silymarin-Encapsulated Xanthan Gum-Stabilized Selenium Nanocarriers for Enhanced Activity Against Amyloid Fibril Cytotoxicity
AAPS PharmSciTech. 2022 Apr 26;23(5):125. doi: 10.1208/s12249-022-02274-0. ABSTRACT The accumulation of amyloid-beta at the neuronal sites is a major pathological hallmark involved in the etiology...