Genetic Characterization and Chemical Identification of Moroccan Cannabis sativa (L.) Seeds: Extraction, and In Vitro and In Silico Biological Evaluation
Plants (Basel). 2024 Jul 15;13(14):1938. doi: 10.3390/plants13141938. ABSTRACT This study investigated the molecular, phytochemical, and biological aspects of ten local Moroccan traditional landrace Cannabis seeds....
Licofelone, a Dual COX/LOX Inhibitor, Ameliorates Paclitaxel-Induced Mechanical Allodynia in Rats in a Cannabinoid Receptor-Dependent Manner
Biomedicines. 2024 Jul 11;12(7):1545. doi: 10.3390/biomedicines12071545. ABSTRACT The use of paclitaxel as a chemotherapeutic drug is limited by the development of dose-dependent paclitaxel-induced neuropathic pain...
Cannabielsoin (CBE), a CBD Oxidation Product, Is a Biased CB1 Agonist
Biomedicines. 2024 Jul 12;12(7):1551. doi: 10.3390/biomedicines12071551. ABSTRACT Cannabielsoin (CBE) is primarily recognized as an oxidation byproduct of cannabidiol (CBD) and a minor mammalian metabolite of...
CBD Versus CBDP: Comparing In Vitro Receptor-Binding Activities
Int J Mol Sci. 2024 Jul 15;25(14):7724. doi: 10.3390/ijms25147724. ABSTRACT Phytocannabinoids with seven-carbon alkyl chains (phorols) have gained a lot of attention, as they are...
Does Trema micranthum (L.) Blume Produce Cannabinoids?
Plants (Basel). 2024 Jul 17;13(14):1951. doi: 10.3390/plants13141951. ABSTRACT There are inconclusive claims in the scientific literature that the species Trema micranthum, widely distributed throughout the...
The Effect of Phytocannabinoids and Endocannabinoids on Nrf2 Activity in the Central Nervous System and Periphery
Neurol Int. 2024 Jul 18;16(4):776-789. doi: 10.3390/neurolint16040057. ABSTRACT The relationship between nuclear factor erythroid 2-related factor 2 (Nrf2) and phytocannabinoids/endocannabinoids (pCBs/eCBs) has been investigated in...
Development of Potential Therapeutic Agents from Black Elderberries (the Fruits of Sambucus nigra L.)
Molecules. 2024 Jun 22;29(13):2971. doi: 10.3390/molecules29132971. ABSTRACT Elderberry (Sambucus nigra L.) is a widespread deciduous shrub, of which the fruits (elderberries) are used in the...
Agave fructanos promote in vitro biofilm formation with a probiotic consortium Lactobacillus delbrueckii ssp. lactis, L. delbrueckii ssp. bulgaricus and Streptococcus thermophilus
Rev Argent Microbiol. 2024 Apr 3:S0325-7541(24)00021-X. doi: 10.1016/j.ram.2024.02.002. Online ahead of print. ABSTRACT In recent years the relationship between the intestinal microbiota, the host and...
Development of Potential Therapeutic Agents from Black Elderberries (the Fruits of Sambucus nigra L.)
Molecules. 2024 Jun 22;29(13):2971. doi: 10.3390/molecules29132971. ABSTRACT Elderberry (Sambucus nigra L.) is a widespread deciduous shrub, of which the fruits (elderberries) are used in the...
Omega-3 Fatty Acid Supplementation on Post-Exercise Inflammation, Muscle Damage, Oxidative Response, and Sports Performance in Physically Healthy Adults-A Systematic Review of Randomized Controlled Trials
Nutrients. 2024 Jun 27;16(13):2044. doi: 10.3390/nu16132044. ABSTRACT Omega-3 is a family of n-3 polyunsaturated fatty acids (PUFAs), which have been used to treat a wide...
Anti-Inflammatory Activity of the Combination of Nobiletin and Docosahexaenoic Acid in Lipopolysaccharide-Stimulated RAW 264.7 Cells: A Potential Synergistic Anti-Inflammatory Effect
Nutrients. 2024 Jun 29;16(13):2080. doi: 10.3390/nu16132080. ABSTRACT This study aimed to investigate a synergistic anti-inflammatory effect of a citrus flavonoid nobiletin and docosahexaenoic acid (DHA),...
n-3 and n-6 Polyunsaturated Fatty Acids Modulate Macrophage-Myocyte Inflammatory Crosstalk and Improve Myocyte Insulin Sensitivity
Nutrients. 2024 Jun 29;16(13):2086. doi: 10.3390/nu16132086. ABSTRACT In obesity, circulating saturated fatty acids (SFAs) and inflammatory cytokines interfere with skeletal muscle insulin signaling, leading to...
IL-17A Drives Oxidative Stress and Cell Growth in A549 Lung Epithelial Cells: Potential Protective Action of Oleuropein
Nutrients. 2024 Jul 3;16(13):2123. doi: 10.3390/nu16132123. ABSTRACT IL-17A drives inflammation and oxidative stress, affecting the progression of chronic lung diseases (asthma, chronic obstructive pulmonary disease...
The Intake of Omega-3 Fatty Acids, the Omega-3 Index in Pregnant Women, and Their Correlations with Gestational Length and Newborn Birth Weight
Nutrients. 2024 Jul 5;16(13):2150. doi: 10.3390/nu16132150. ABSTRACT BACKGROUND: During pregnancy, the demand for omega-3 fatty acids, notably docosahexaenoic acid (DHA), escalates for both maternal and...
Increasing the Survival of a Neuronal Model of Alzheimer’s Disease Using Docosahexaenoic Acid, Restoring Endolysosomal Functioning by Modifying the Interactions between the Membrane Proteins C99 and Rab5
Int J Mol Sci. 2024 Jun 21;25(13):6816. doi: 10.3390/ijms25136816. ABSTRACT Docosahexaenoic acid (DHA, C22:6 ω3) may be involved in various neuroprotective mechanisms that could prevent...