Pharmacological insights emerging from the characterization of a large collection of synthetic cannabinoid receptor agonists designer drugs
Biomed Pharmacother. 2023 May 24;164:114934. doi: 10.1016/j.biopha.2023.114934. Online ahead of print. ABSTRACT Synthetic cannabinoid receptor agonists (SCRAs) constitute the largest and most defiant group of...
Endocannabinoid modulation of allergic responses: Focus on the control of FcεRI-mediated mast cell activation
Eur J Cell Biol. 2023 May 19;102(2):151324. doi: 10.1016/j.ejcb.2023.151324. Online ahead of print. ABSTRACT Allergic reactions are highly prevalent pathologies initiated by the production of...
Role of omega-3 and omega-6 endocannabinoids in cardiopulmonary pharmacology
Adv Pharmacol. 2023;97:375-422. doi: 10.1016/bs.apha.2023.02.003. Epub 2023 Mar 28. ABSTRACT Endocannabinoids are derived from dietary omega-3 and omega-6 fatty acids and play an important role...
A systematic review of health state utility values and psychometric performance of generic preference-based instruments for children and adolescents with mental health problems
Qual Life Res. 2023 May 26. doi: 10.1007/s11136-023-03441-x. Online ahead of print. ABSTRACT AIMS: This paper aims to systematically identify reported health state utility values...
Cannabinoids Reduce Melanoma Cell Viability and Do Not Interfere with Commonly Used Targeted Therapy in Metastatic Melanoma In Vivo and In Vitro
Biology (Basel). 2023 May 12;12(5):706. doi: 10.3390/biology12050706. ABSTRACT Background: Cannabinoids are mainly used for recreational purposes, but also made their way into oncology, since these...
Antitumor Effects of Cannabis sativa Bioactive Compounds on Colorectal Carcinogenesis
Biomolecules. 2023 Apr 28;13(5):764. doi: 10.3390/biom13050764. ABSTRACT Cannabis sativa is a multipurpose plant that has been used in medicine for centuries. Recently, considerable research has...
Non-Psychoactive Cannabinoid Modulation of Nociception and Inflammation Associated with a Rat Model of Pulpitis
Biomolecules. 2023 May 16;13(5):846. doi: 10.3390/biom13050846. ABSTRACT Despite advancements in dental pain management, one of the most common reasons for emergency dental care is orofacial...
Sphingosine Kinases at the Intersection of Pro-Inflammatory LPS and Anti-Inflammatory Endocannabinoid Signaling in BV2 Mouse Microglia Cells
Int J Mol Sci. 2023 May 9;24(10):8508. doi: 10.3390/ijms24108508. ABSTRACT Microglia, the resident immune cells of the central nervous system, play important roles in brain...
Novel GPR18 Ligands in Rodent Pharmacological Tests: Effects on Mood, Pain, and Eating Disorders
Int J Mol Sci. 2023 May 20;24(10):9046. doi: 10.3390/ijms24109046. ABSTRACT The lack of selective pharmacological tools has limited the full unraveling of G protein-coupled receptor...
Avatar Intervention for Cannabis Use Disorder in Individuals with Severe Mental Disorders: A Pilot Study
J Pers Med. 2023 Apr 29;13(5):766. doi: 10.3390/jpm13050766. ABSTRACT Cannabis use disorder (CUD) is a complex issue, even more so when it is comorbid with...
Antibacterial and Analgesic Properties of Beta-Caryophyllene in a Murine Urinary Tract Infection Model
Molecules. 2023 May 17;28(10):4144. doi: 10.3390/molecules28104144. ABSTRACT Beta-caryophyllene has demonstrated anti-inflammatory effects in a variety of conditions, including interstitial cystitis. These effects are mediated primarily...
Cannabinoid and Opioid Receptor Affinity and Modulation of Cancer-Related Signaling Pathways of Machaeriols and Machaeridiols from Machaerium Pers
Molecules. 2023 May 18;28(10):4162. doi: 10.3390/molecules28104162. ABSTRACT Machaeriols and machaeridiols are unique hexahydrodibenzopyran-type aralkyl phytocannabinoids isolated from Machaerium Pers. Earlier studies of machaeriol A (1)...
Acute Toxicity and Pharmacokinetic Profile of an EU-GMP-Certified Cannabis sativa L. in Rodents
Pharmaceuticals (Basel). 2023 May 3;16(5):694. doi: 10.3390/ph16050694. ABSTRACT The conundrum of Cannabis sativa’s applications for therapeutical purposes is set apart by the hundreds of known...
Longitudinal associations between insomnia, cannabis use and stress among US veterans
J Sleep Res. 2023 May 26:e13945. doi: 10.1111/jsr.13945. Online ahead of print. ABSTRACT Insomnia is highly prevalent among military veterans, with rates nearly double that...
Evaluating global Vaccinium germplasm for resistance against invasive Drosophila suzukii (Diptera: Drosophilidae)
J Econ Entomol. 2023 May 26:toad081. doi: 10.1093/jee/toad081. Online ahead of print. ABSTRACT Control of spotted-wing Drosophila, Drosophila suzukii, in small fruits emphasizes biological, cultural,...