Identification of MYB gene family in medicinal tea tree Melaleuca alternifolia (Maiden and Betche) cheel and analysis of members regulating terpene biosynthesis
Mol Biol Rep. 2024 Jan 4;51(1):70. doi: 10.1007/s11033-023-09019-7. ABSTRACT BACKGROUND: The tea tree (Melaleuca alternifolia) is renowned for its production of tea tree oil, an...
The Effectiveness of Perinatal Omega-3 Supplements in Neurodevelopment and Physical Growth of 9- and 12-month-old Infants: A Follow-up of a Clinical Trial
Curr Pediatr Rev. 2024 Jan 3. doi: 10.2174/0115733963273591231214112617. Online ahead of print. ABSTRACT BACKGROUND: Omega-3 fatty acids (FAs) are essential long-chain polyunsaturated fatty acids (LCPUFAs)...
Cost-Effectiveness of Icosapent Ethyl in REDUCE-IT USA: Results From Patients Randomized in the United States
J Am Heart Assoc. 2024 Jan 2;13(1):e032413. doi: 10.1161/JAHA.123.032413. Epub 2023 Dec 29. ABSTRACT BACKGROUND: In 3146 REDUCE-IT USA (Reduction of Cardiovascular Events With Icosapent...
Conceptual foundations of acetylcarnitine supplementation in neuropsychiatric long COVID syndrome: a narrative review
Eur Arch Psychiatry Clin Neurosci. 2024 Jan 3. doi: 10.1007/s00406-023-01734-3. Online ahead of print. ABSTRACT Post-acute sequelae of COVID-19 can present as multi-organ pathology, with...
Cannabinoid type 2 receptors play a crucial role in social defeat-induced depression
J Affect Disord. 2024 Jan 1:S0165-0327(23)01558-6. doi: 10.1016/j.jad.2023.12.089. Online ahead of print. ABSTRACT BACKGROUND: The endocannabinoid system plays a crucial role in regulating mood, but...
Cannabis for medical use versus opioids for chronic non-cancer pain: a systematic review and network meta-analysis of randomised clinical trials
BMJ Open. 2024 Jan 3;14(1):e068182. doi: 10.1136/bmjopen-2022-068182. ABSTRACT OBJECTIVE: The objective of this study is to evaluate the comparative benefits and harms of opioids and...
Dual Engineering of Olivetolic Acid Cyclase and Tetraketide Synthase for the Formation of Longer Alkyl-Chain Olivetolic Acid Analogs and Their Antibacterial Activities
Chem Pharm Bull (Tokyo). 2024;72(1):1-10. doi: 10.1248/cpb.c23-00692. ABSTRACT Among presently used pharmaceuticals, about 60% were developed from natural products with unique chemical diversity and biological...
ScreenPlus: A comprehensive, multi-disorder newborn screening program
Mol Genet Metab Rep. 2023 Dec 14;38:101037. doi: 10.1016/j.ymgmr.2023.101037. eCollection 2024 Mar. ABSTRACT The increasing availability of novel therapies highlights the importance of screening newborns...
Outcomes of early social experiences on glucocorticoid and endocannabinoid systems in the prefrontal cortex of male and female adolescent rats
Front Cell Neurosci. 2023 Dec 20;17:1270195. doi: 10.3389/fncel.2023.1270195. eCollection 2023. ABSTRACT Social and emotional experiences differently shape individual’s neurodevelopment inducing substantial changes in neurobiological substrates...
Dual Engineering of Olivetolic Acid Cyclase and Tetraketide Synthase for the Formation of Longer Alkyl-Chain Olivetolic Acid Analogs and Their Antibacterial Activities
Chem Pharm Bull (Tokyo). 2024;72(1):1-10. doi: 10.1248/cpb.c23-00692. ABSTRACT Among presently used pharmaceuticals, about 60% were developed from natural products with unique chemical diversity and biological...
The neuropsychopharmacology of acetyl-L-carnitine (LAC): basic, translational and therapeutic implications
Discov Ment Health. 2024 Jan 2;4(1):2. doi: 10.1007/s44192-023-00056-z. ABSTRACT Mitochondrial metabolism can contribute to nuclear histone acetylation among other epigenetic mechanisms. A central aspect of...
Available but inaccessible: patient experiences during the first 2 years of a primary care-based medical cannabis program at an academic medical center
Harm Reduct J. 2024 Jan 2;21(1):1. doi: 10.1186/s12954-023-00919-2. ABSTRACT BACKGROUND: Medical cannabis use and public acceptance in the United States have increased over the past...
Inhibitory effects of selected cannabinoids against dipeptidyl peptidase IV, an enzyme linked to type 2 diabetes
Heliyon. 2023 Dec 6;10(1):e23289. doi: 10.1016/j.heliyon.2023.e23289. eCollection 2024 Jan 15. ABSTRACT ETHNOPHARMACOLOGICAL RELEVANCE: In recent times the decriminalisation of cannabis globally has increased its use...
Cannabinoid CB1 Receptor Expression and Localization in the Dorsal Horn of Male and Female Rat and Human Spinal Cord
Can J Pain. 2023 Nov 28;7(2):2264895. doi: 10.1080/24740527.2023.2264895. eCollection 2023. ABSTRACT BACKGROUND: Preclinical and clinical evidence suggests that cannabis has potential analgesic properties. However, cannabinoid...
The adjuvant treatment role of ω-3 fatty acids by regulating gut microbiota positively in the acne vulgaris
J Dermatolog Treat. 2024 Dec;35(1):2299107. doi: 10.1080/09546634.2023.2299107. Epub 2024 Jan 2. ABSTRACT Objectives:We aimed to explore the potential role of omega-3 (ω-3) fatty acids on...