Fermented mixed grain ameliorates chronic stress-induced depression-like behavior and memory deficit

Food Sci Biotechnol. 2023 Jul 27;33(4):969-979. doi: 10.1007/s10068-023-01387-x. eCollection 2024 Mar.

ABSTRACT

Fermented mixed grain (FG) has beneficial anti-cancer, antioxidant, and anti-inflammatory effects. In this study, we investigated the effects of FG on gut inflammation, brain dysfunction, and anxiety/depression-like behavior induced by unpredictable chronic mild stress (UCMS) in mice. Mice were administered mixed grain or FG for 3 weeks and were then exposed to UCMS for 4 weeks. FG administration ameliorated stress-induced anxiety/despair-like behavior. FG administration also prevented UCMS-induced memory impairment. Additionally, the mRNA levels of 5-HTR1A and IL-6 were restored to normal levels in the brains of FG-administered mice. FG administration also inhibited intestinal damage in stressed mice compared with that in the UCMS (without FG) group. These results suggest that FG can alleviate stress-induced intestinal damage, brain dysfunction, and cognitive impairment.

PMID:38371678 | PMC:PMC10866851 | DOI:10.1007/s10068-023-01387-x