HomeNutritionDietary blueberry ameliorates vascular complications in diabetic mice possibly through NOX4 and modulates composition and functional diversity of gut microbes

Dietary blueberry ameliorates vascular complications in diabetic mice possibly through NOX4 and modulates composition and functional diversity of gut microbes

February 5, 2022

Mol Nutr Food Res. 2022 Feb 4:e2100784. doi: 10.1002/mnfr.202100784. Online ahead of print.

ABSTRACT

SCOPE: In diabetes, endothelial inflammation and dysfunction play a pivotal role in the development of vascular disease. We investigated the effect of dietary blueberries on vascular complications and gut microbiome in diabetic mice.

METHODS AND RESULTS: Seven-week-old diabetic db/db mice consumed a standard diet (db/db) or a diet supplemented with 3.8% freeze-dried blueberry (db/db+BB) for 10 weeks. Control db/+ mice fed a standard diet (db/+). Vascular inflammation was assessed by measuring the monocyte binding to vasculature and inflammatory markers. Isometric tension procedures were used to assess mesenteric artery function. db/db mice exhibited enhanced vascular inflammation and reduced endothelial-dependent vasorelaxation as compared to db/+ mice but these were improved in db/db+BB mice. Blueberry supplementation reduced the expression of NOX4 and IκKβ in the aortic vessel and vascular endothelial cells (ECs) isolated from db/db+BB compared to db/db mice. The blueberry metabolites serum reduced glucose and palmitate induced endothelial inflammation in mouse aortic ECs. Further, blueberry supplementation increases commensal microbes and modulates the functional potential of gut microbes in diabetic mice.

CONCLUSIONS: Dietary blueberry suppresses vascular inflammation, attenuates arterial endothelial dysfunction and supports the growth of commensal microbes in diabetic mice. The endothelial specific vascular benefits of blueberries are mediated through NOX4 signaling. This article is protected by copyright. All rights reserved.

PMID:35120277 | DOI:10.1002/mnfr.202100784

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About The Author

Patrick Blanchard MD

Meet Dr. Blanchard Dr. Blanchard’s medical practice is an embodiment of Integrative health which brings conventional and complementary approaches together in a coordinated way. Conveniently located in sunny Florida and over the internet with ValiseMD’s secure HIPPA compliant telXmed servers. Since 1994, patients with a wide range of challenging medical problems have achieved optimum health using the best of natural medicine, judiciously combined with high-tech innovations. Breakthroughs are often achieved even after patients have consulted mainstream specialists and holistic practitioners. Dr. Blanchard is founder and CEO of ValiseMD, Inc. He is board certified in Family Medicine since 1994 and awarded Fellow of the American Academy of Family Physicians in 2001. He received the ‘Teacher of the Year’ award from the University of Kansas School of Medicine at completion of his residency in Family Medicine. He completed a fellowship at Wake Forest University in the field of vascular neurosonology. He holds a medical patent in the field of Gastroenterology. He holds an unrestricted license to practice medicine and surgery in Florida. He started his medical career as a Emergency Medical Technician, then as a Paramedic and later a Medical Doctor.