The clinical relevance of omega-3 fatty acids in the management of hypertriglyceridemia
Lipids Health Dis. 2016 Jul 22;15(1):118. doi: 10.1186/s12944-016-0286-4. ABSTRACT Hypertriglyceridemia (triglycerides > 150 mg/dL) affects ~25 % of the United States (US) population and is...
Bioavailability of tomato polyphenols is enhanced by processing and fat addition: Evidence from a randomized feeding trial
Mol Nutr Food Res. 2016 Jul;60(7):1578-89. doi: 10.1002/mnfr.201500820. Epub 2016 May 9. ABSTRACT SCOPE: Tomato contains a variety of phenolics associated with health-promoting properties. However,...
Nanoemulsifying drug delivery system to improve the bioavailability of piroxicam
Pharm Dev Technol. 2017 May;22(3):445-456. doi: 10.1080/10837450.2016.1231810. Epub 2016 Oct 25. ABSTRACT OBJECTIVE: The aim of this study is to develop and characterize self-nanoemulsifying drug...
Microemulsions containing long-chain oil ethyl oleate improve the oral bioavailability of piroxicam by increasing drug solubility and lymphatic transportation simultaneously
Int J Pharm. 2016 Sep 25;511(2):709-18. doi: 10.1016/j.ijpharm.2016.07.061. Epub 2016 Jul 26. ABSTRACT Drug solubility and lymphatic transport enhancements are two main pathways to improve...
The influence of lipid droplet size on the oral bioavailability of vitamin D2 encapsulated in emulsions: an in vitro and in vivo study
Food Funct. 2017 Feb 22;8(2):767-777. doi: 10.1039/c6fo01565d. ABSTRACT Vitamin D deficiency is prevalent in some populations leading to adverse health effects, and therefore there is...
Dietary intake of n-3 PUFAs modifies the absorption, distribution and bioavailability of fatty acids in the mouse gastrointestinal tract
Lipids Health Dis. 2017 Jan 17;16(1):10. doi: 10.1186/s12944-016-0399-9. ABSTRACT BACKGROUND: Dietary polyunsaturated fatty acids (PUFAs), especially n-3 PUFAs, are important for human health. The intestinal...
Wax Ester Rich Oil From The Marine Crustacean, Calanus finmarchicus, is a Bioavailable Source of EPA and DHA for Human Consumption
Lipids. 2016 Oct;51(10):1137-1144. doi: 10.1007/s11745-016-4189-y. Epub 2016 Sep 7. ABSTRACT Oil from the marine copepod, Calanus finmarchicus, which contains >86 % of fatty acids present...
Effects of Food on the Pharmacokinetics of Omega-3-Carboxylic Acids in Healthy Japanese Male Subjects: A Phase I, Randomized, Open-label, Three-period, Crossover Trial
J Atheroscler Thromb. 2017 Sep 1;24(9):980-987. doi: 10.5551/jat.38737. Epub 2017 Mar 24. ABSTRACT AIMS: Omega-3-carboxylic acids (OM3-CA) contain omega-3 free fatty acids, such as eicosapentaenoic...
A Novel ω-3 Acid Ethyl Ester Formulation Incorporating Advanced Lipid TechnologiesTM (ALT®) Improves Docosahexaenoic Acid and Eicosapentaenoic Acid Bioavailability Compared with Lovaza®
Clin Ther. 2017 Mar;39(3):581-591. doi: 10.1016/j.clinthera.2017.01.020. Epub 2017 Feb 9. ABSTRACT PURPOSE: The US Food and Drug Administration has approved several highly purified ω-3 fatty...
Modeling the dose effects of soybean oil in salad dressing on carotenoid and fat-soluble vitamin bioavailability in salad vegetables
Am J Clin Nutr. 2017 Oct;106(4):1041-1051. doi: 10.3945/ajcn.117.153635. Epub 2017 Aug 16. ABSTRACT Background: Previously, we showed that vegetable oil is necessary for carotenoid absorption...
Minimal food effect for eicosapentaenoic acid and docosahexaenoic acid bioavailability from omega-3-acid ethyl esters with an Advanced Lipid TechnologiesTM (ALT®)-based formulation
J Clin Lipidol. 2017 Mar-Apr;11(2):394-405. doi: 10.1016/j.jacl.2017.01.017. Epub 2017 Feb 9. ABSTRACT BACKGROUND: The absorption of eicosapentaenoic acid (EPA; 20:5n-3) and docosahexaenoic acid (DHA; 22:6n-3)...
A novel self-micro-emulsifying delivery system (SMEDS) formulation significantly improves the fasting absorption of EPA and DHA from a single dose of an omega-3 ethyl ester concentrate
Lipids Health Dis. 2017 Oct 16;16(1):204. doi: 10.1186/s12944-017-0589-0. ABSTRACT BACKGROUND: Absorption of EPA and DHA from Omega-3-acid ethyl ester (EE) concentrate supplements occurs most efficiently...
Changes in Bioavailability of Omega-3 (DHA) through Alpha-Tocopheryl Phosphate Mixture (TPM) after Oral Administration in Rats
Nutrients. 2017 Sep 20;9(9):1042. doi: 10.3390/nu9091042. ABSTRACT Benefits of Omega-3 Docosahexaenoic acid (DHA) supplements are hindered by their poor solubility and bioavailability. This study investigated...
Relative levels of dietary EPA and DHA impact gastric oxidation and essential fatty acid uptake
J Nutr Biochem. 2018 May;55:68-75. doi: 10.1016/j.jnutbio.2017.11.007. Epub 2017 Dec 10. ABSTRACT Previous research showed that increasing the proportion of docosahexaenoic acid (DHA) in marine...
Oral Delivery of Highly Lipophilic, Poorly Water-Soluble Drugs: Self-Emulsifying Drug Delivery Systems to Improve Oral Absorption and Enable High-Dose Toxicology Studies of a Cholesteryl Ester Transfer Protein Inhibitor in Preclinical Species
J Pharm Sci. 2018 May;107(5):1352-1360. doi: 10.1016/j.xphs.2018.01.003. Epub 2018 Jan 6. ABSTRACT BMS-A is an inhibitor of cholesteryl ester transfer protein and is a highly...