CB1 Receptor Negative Allosteric Modulators as a Potential Tool to Reverse Cannabinoid Toxicity
Molecules. 2024 Apr 20;29(8):1881. doi: 10.3390/molecules29081881. ABSTRACT While the opioid crisis has justifiably occupied news headlines, emergency rooms are seeing many thousands of visits for...
A Novel Non-Psychoactive Fatty Acid from a Marine Snail, Conus inscriptus, Signals Cannabinoid Receptor 1 (CB1) to Accumulate Apoptotic C16:0 and C18:0 Ceramides in Teratocarcinoma Cell Line PA1
Molecules. 2024 Apr 11;29(8):1737. doi: 10.3390/molecules29081737. ABSTRACT The cannabinoid-type I (CB1) receptor functions as a double-edged sword to decide cell fate: apoptosis/survival. Elevated CB1 receptor...
Exploring Cannabinoids with Enhanced Binding Affinity for Targeting the Expanded Endocannabinoid System: A Promising Therapeutic Strategy for Alzheimer’s Disease Treatment
Pharmaceuticals (Basel). 2024 Apr 19;17(4):530. doi: 10.3390/ph17040530. ABSTRACT Despite decades of rigorous research and numerous clinical trials, Alzheimer’s disease (AD) stands as a notable healthcare...
Exploring Microbial Metabolite Receptors in Inflammatory Bowel Disease: An In Silico Analysis of Their Potential Role in Inflammation and Fibrosis
Pharmaceuticals (Basel). 2024 Apr 12;17(4):492. doi: 10.3390/ph17040492. ABSTRACT Metabolites produced by dysbiotic intestinal microbiota can influence disease pathophysiology by participating in ligand-receptor interactions. Our aim...
Sharing Advice that We Give to People with Parkinson’s Disease
J Parkinsons Dis. 2024;14(3):361-362. doi: 10.3233/JPD-249003. NO ABSTRACT PMID:38669485 | DOI:10.3233/JPD-249003...
Antimicrobial, Probiotic, and Immunomodulatory Potential of Cannabis sativa Extract and Delivery Systems
Antibiotics (Basel). 2024 Apr 17;13(4):369. doi: 10.3390/antibiotics13040369. ABSTRACT The compounds present in hemp show multidirectional biological activity. It is related to the presence of secondary...
Assessment of Clinical Outcomes in Patients With Osteoarthritis: Analysis From the UK Medical Cannabis Registry
J Pain Palliat Care Pharmacother. 2024 Apr 26:1-14. doi: 10.1080/15360288.2024.2340076. Online ahead of print. ABSTRACT Osteoarthritis accounts for 0.6% of disability-adjusted life years globally. There...
Arbuscular Mycorrhizal Fungi-Mediated Modulation of Physiological, Biochemical, and Secondary Metabolite Responses in Hemp (Cannabis sativa L.) under Salt and Drought Stress
J Fungi (Basel). 2024 Apr 12;10(4):283. doi: 10.3390/jof10040283. ABSTRACT The increasing impact of global climate change has resulted in adversity stresses, like salt and drought,...
Cannabis Use Characteristics Associated with Self-Reported Cognitive Function in a Nationally Representative U.S. sample
Subst Use Misuse. 2024 Apr 25:1-10. doi: 10.1080/10826084.2024.2340975. Online ahead of print. ABSTRACT BACKGROUND: With increases in cannabis use and potency, there is a need...
Cannabis use and emergency department symptoms: Discordance between patient and provider perspectives
Am J Emerg Med. 2024 Apr 21:S0735-6757(24)00200-6. doi: 10.1016/j.ajem.2024.04.041. Online ahead of print. NO ABSTRACT PMID:38664105 | DOI:10.1016/j.ajem.2024.04.041...
Defining a public health approach to substance use: Perspectives from professionals and practitioners across Canada
Int J Drug Policy. 2024 Apr 24;128:104427. doi: 10.1016/j.drugpo.2024.104427. Online ahead of print. ABSTRACT BACKGROUND: While increasingly referenced in the literature and policy discussions, a...
Assessing the preparedness and future-readiness of Malaysian community pharmacists in Klang Valley regarding the use of medical marijuana
BMC Health Serv Res. 2024 Apr 25;24(1):524. doi: 10.1186/s12913-024-11008-w. ABSTRACT BACKGROUND: This study investigated community pharmacists’ level of knowledge and attitude towards medical marijuana and...
Type 2 cannabinoid receptor expression on microglial cells regulates neuroinflammation during graft versus host disease
J Clin Invest. 2024 Apr 25:e175205. doi: 10.1172/JCI175205. Online ahead of print. ABSTRACT Neuroinflammation is a recognized complication of immunotherapeutic approaches such as immune checkpoint...
Indirect and direct cannabinoid agonists differentially affect mesolimbic dopamine release and related behaviors
Behav Neurosci. 2024 Apr;138(2):108-124. doi: 10.1037/bne0000582. ABSTRACT The cannabinoid system is being researched as a potential pharmaceutical target for a multitude of disorders. The present...
Cannabinoid type-1 receptor signaling in dopaminergic Engrailed-1 expressing neurons modulates motivation and depressive-like behavior
Front Mol Neurosci. 2024 Apr 4;17:1379889. doi: 10.3389/fnmol.2024.1379889. eCollection 2024. ABSTRACT The endocannabinoid system comprises highly versatile signaling functions within the nervous system. It is...