Effects of CB1 receptor negative allosteric modulator Org27569 on oxycodone withdrawal symptoms in mice
Psychopharmacology (Berl). 2024 Apr 27. doi: 10.1007/s00213-024-06591-z. Online ahead of print. ABSTRACT RATIONALE/OBJECTIVES: Targeting cannabinoid receptor type 1 (CB1R) has shown promise for treating opioid...
Sex-Specific Differences and the Role of Environmental Enrichment in the Expression of Hippocampal CB(1) Receptors following Chronic Unpredictable Stress
Brain Sci. 2024 Apr 3;14(4):357. doi: 10.3390/brainsci14040357. ABSTRACT Stress-related mental disorders have become increasingly prevalent, thus endangering mental health worldwide. Exploring stress-associated brain alterations is...
Neuromodulation for Cannabis Use: A Scoping Review
Brain Sci. 2024 Apr 2;14(4):356. doi: 10.3390/brainsci14040356. ABSTRACT This scoping review explores the use of neuromodulation techniques in individuals with cannabis use. Our goal was...
Bipiperidinyl Derivatives of Cannabidiol Enhance Its Antiproliferative Effects in Melanoma Cells
Antioxidants (Basel). 2024 Apr 17;13(4):478. doi: 10.3390/antiox13040478. ABSTRACT Cannabis and its major cannabinoid cannabidiol (CBD) are reported to exhibit anticancer activity against skin tumors. However,...
Analysis of the Relationship between Psychiatric and Addiction-Related Disorders in Patients of an Outpatient Addiction Treatment Clinic for Children and Adolescents
Children (Basel). 2024 Mar 31;11(4):414. doi: 10.3390/children11040414. ABSTRACT INTRODUCTION: Dual diagnosis is used in addiction medicine to refer to the co-occurrence of an addiction-related disorder...
An observational time-series study on the behavioral effects of adjunctive artisanal cannabidiol use by adults with treatment resistant epilepsies
BMC Neurol. 2024 Apr 26;24(1):141. doi: 10.1186/s12883-024-03646-8. ABSTRACT BACKGROUND: For approximately 30% of people with epilepsy, seizures are not well-controlled by anti-seizure medication (ASM). This...
Effectiveness of a universal, school-based, online programme for the prevention of anxiety, depression, and substance misuse among adolescents in Australia: 72-month outcomes from a cluster-randomised controlled trial
Lancet Digit Health. 2024 May;6(5):e334-e344. doi: 10.1016/S2589-7500(24)00046-3. ABSTRACT BACKGROUND: The CSC study found that the universal delivery of a school-based, online programme for the prevention...
Phytocannabinoids: Exploring Pharmacological Profiles and Their Impact on Therapeutical Use
Int J Mol Sci. 2024 Apr 10;25(8):4204. doi: 10.3390/ijms25084204. ABSTRACT Phytocannabinoids, a diverse group of naturally occurring compounds extracted from the Cannabis plant, have attracted...
Heteromers Formed by GPR55 and Either Cannabinoid CB(1) or CB(2) Receptors Are Upregulated in the Prefrontal Cortex of Multiple Sclerosis Patients
Int J Mol Sci. 2024 Apr 10;25(8):4176. doi: 10.3390/ijms25084176. ABSTRACT Multiple sclerosis (MS) is an autoimmune, inflammatory, and neurodegenerative disease of the central nervous system...
Effects of Cannabidiol, ∆9-Tetrahydrocannabinol, and WIN 55-212-22 on the Viability of Canine and Human Non-Hodgkin Lymphoma Cell Lines
Biomolecules. 2024 Apr 19;14(4):495. doi: 10.3390/biom14040495. ABSTRACT In our previous study, we demonstrated the impact of overexpression of CB1 and CB2 cannabinoid receptors and the...
Increasing CB2 Receptor Activity after Early Life Stress Prevents Depressive Behavior in Female Rats
Biomolecules. 2024 Apr 10;14(4):464. doi: 10.3390/biom14040464. ABSTRACT Early adversity, the loss of the inhibitory GABAergic interneuron parvalbumin, and elevated neuroinflammation are associated with depression. Individuals...
Immunostimulatory and Antibacterial Effects of Cannabis sativa L. Leaves on Broilers
Animals (Basel). 2024 Apr 11;14(8):1159. doi: 10.3390/ani14081159. ABSTRACT The aim of this study was to evaluate the effect of dried Cannabis sativa L. leaves as...
Paclitaxel-Associated Mechanical Sensitivity and Neuroinflammation Are Sex-, Time-, and Site-Specific and Prevented through Cannabigerol Administration in C57Bl/6 Mice
Int J Mol Sci. 2024 Apr 12;25(8):4277. doi: 10.3390/ijms25084277. ABSTRACT Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most prevalent and dose-limiting complications in chemotherapy...
CB1 Receptor Negative Allosteric Modulators as a Potential Tool to Reverse Cannabinoid Toxicity
Molecules. 2024 Apr 20;29(8):1881. doi: 10.3390/molecules29081881. ABSTRACT While the opioid crisis has justifiably occupied news headlines, emergency rooms are seeing many thousands of visits for...
A Novel Non-Psychoactive Fatty Acid from a Marine Snail, Conus inscriptus, Signals Cannabinoid Receptor 1 (CB1) to Accumulate Apoptotic C16:0 and C18:0 Ceramides in Teratocarcinoma Cell Line PA1
Molecules. 2024 Apr 11;29(8):1737. doi: 10.3390/molecules29081737. ABSTRACT The cannabinoid-type I (CB1) receptor functions as a double-edged sword to decide cell fate: apoptosis/survival. Elevated CB1 receptor...