Effects of recent cannabis consumption on eye-tracking and pupillometry
Front Neurosci. 2024 Apr 9;18:1358491. doi: 10.3389/fnins.2024.1358491. eCollection 2024. ABSTRACT INTRODUCTION: Cannabis consumption is known to immediately affect ocular and oculomotor function, however, cannabis consumption...
The Use of Tetrahydrocannabinol Is Associated with an Increase in Survival Time in Palliative Cancer Patients: A Retrospective Multicenter Cohort Study
Med Cannabis Cannabinoids. 2024 Mar 14;7(1):59-67. doi: 10.1159/000538311. eCollection 2024 Jan-Dec. ABSTRACT INTRODUCTION: Tetrahydrocannabinol (THC) is often prescribed for ambulatory palliative patients to improve sleep...
Effects of Cannabidiol and Δ9-Tetrahydrocannabinol on Cytochrome P450 Enzymes: A Systematic Review
Drug Metab Rev. 2024 Apr 24:1-20. doi: 10.1080/03602532.2024.2346767. Online ahead of print. ABSTRACT Due to legal, political, and cultural changes, the use of cannabis has...
Quantitative Estimation of Promoter Activity in Cannabis sativa Using Agroinfiltration-Based Transient Gene Expression
Methods Mol Biol. 2024;2787:245-253. doi: 10.1007/978-1-0716-3778-4_16. ABSTRACT To properly assess promoter activity, which is critical for understanding biosynthetic pathways in different plant species, we use...
DeLA-DrugSelf: Empowering multi-objective de novo design through SELFIES molecular representation
Comput Biol Med. 2024 Apr 16;175:108486. doi: 10.1016/j.compbiomed.2024.108486. Online ahead of print. ABSTRACT In this paper, we introduce DeLA-DrugSelf, an upgraded version of DeLA-Drug [J....
Endocannabinoid remodeling in murine cachexic muscle associates with catabolic and metabolic regulation
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 21:167179. doi: 10.1016/j.bbadis.2024.167179. Online ahead of print. ABSTRACT Muscle degeneration is a common feature in cancer cachexia...
Rapid Screening of New Psychoactive Substances Using pDART-QqQ-MS
J Am Soc Mass Spectrom. 2024 Apr 23. doi: 10.1021/jasms.4c00124. Online ahead of print. ABSTRACT Drug abuse is a severe social problem worldwide. Particularly, the...
A simple aptamer-dye fluorescence sensor for detecting Δ9-tetrahydrocannabinol and its metabolite in urban sewage
Chem Commun (Camb). 2024 Apr 23. doi: 10.1039/d4cc00824c. Online ahead of print. ABSTRACT This work developed an aptamer-dye complex as a label-free ratiometric fluorescence sensor...
Cannabidiol potentiates hyperpolarization-activated cyclic nucleotide-gated (HCN4) channels
J Gen Physiol. 2024 Jun 3;156(6):e202313505. doi: 10.1085/jgp.202313505. Epub 2024 Apr 23. ABSTRACT Cannabidiol (CBD), the main non-psychotropic phytocannabinoid produced by the Cannabis sativa plant,...
Genetic insights into agronomic and morphological traits of drug-type cannabis revealed by genome-wide association studies
Sci Rep. 2024 Apr 22;14(1):9162. doi: 10.1038/s41598-024-58931-w. ABSTRACT Cannabis sativa L., previously concealed by prohibition, is now a versatile and promising plant, thanks to recent...
Adolescent Cannabis Use and Suicidality
Am Fam Physician. 2024 Apr;109(4):369-370. NO ABSTRACT PMID:38648838...
Hexahydrocannabinol (HHC) and delta(9)-tetrahydrocannabinol (delta(9)-THC) driven activation of cannabinoid receptor 1 results in biased intracellular signaling
Sci Rep. 2024 Apr 22;14(1):9181. doi: 10.1038/s41598-024-58845-7. ABSTRACT The Cannabis sativa plant has been used for centuries as a recreational drug and more recently in...
Effects of Recreational Cannabis Legalization on Mental Health: Scoping Review
Psychiatr Serv. 2024 Apr 23:appips20230434. doi: 10.1176/appi.ps.20230434. Online ahead of print. ABSTRACT OBJECTIVE: Recreational cannabis legalization (RCL) is expanding rapidly. RCL’s effects on mental health...
Maternal Substance Use and Early-Life Adversity: Inducing Drug Dependence in Offspring, Interactions, Mechanisms, and Treatments
Addict Health. 2024 Feb;16(1):51-66. doi: 10.34172/ahj.2024.1478. Epub 2024 Feb 29. ABSTRACT The likelihood of substance dependency in offspring is increased in cases when there is...
Oral Delta-9-Tetrahydrocannabinol (THC) Increases Parasympathetic Activity and Supraspinal Conditioned Pain Modulation in Chronic Neuropathic Pain Male Patients: A Crossover, Double-Blind, Placebo-Controlled Trial
CNS Drugs. 2024 May;38(5):375-385. doi: 10.1007/s40263-024-01085-0. Epub 2024 Apr 10. ABSTRACT BACKGROUND: Disordered autonomic nervous system regulation and supraspinal pain inhibition have been repeatedly described...