Bioactive Flavonoids Icaritin and Icariin Protect against Cerebral Ischemia-Reperfusion-Associated Apoptosis and Extracellular Matrix Accumulation in an Ischemic Stroke Mouse Model
Biomedicines. 2021 Nov 19;9(11):1719. doi: 10.3390/biomedicines9111719. ABSTRACT Stroke, which is the second leading cause of mortality in the world, is urgently needed to explore the...
Icariin Protects H9c2 Rat Cardiomyoblasts from Doxorubicin-Induced Cardiotoxicity: Role of Caveolin-1 Upregulation and Enhanced Autophagic Response
Nutrients. 2021 Nov 14;13(11):4070. doi: 10.3390/nu13114070. ABSTRACT Doxorubicin (Doxo) is a widely used antineoplastic drug which often induces cardiomyopathy, leading to congestive heart failure through...
Icariin activates autophagy to trigger TGFbeta1 upregulation and promote angiogenesis in EA.hy926 human vascular endothelial cells
Bioengineered. 2021 Nov 30. doi: 10.1080/21655979.2021.2011637. Online ahead of print. ABSTRACT Angiogenesis plays an important role in tissue development and repair, and how to regulate...
3D printing of alginate dialdehyde-gelatin (ADA-GEL) hydrogels incorporating phytotherapeutic icariin loaded mesoporous SiO(2)-CaO nanoparticles for bone tissue engineering
Mater Sci Eng C Mater Biol Appl. 2021 Dec;131:112470. doi: 10.1016/j.msec.2021.112470. Epub 2021 Oct 2. ABSTRACT 3D printing enables a better control over the microstructure...
Icariin accelerates cartilage defect repair by promoting chondrogenic differentiation of BMSCs under conditions of oxygen-glucose deprivation
J Cell Mol Med. 2021 Dec 3. doi: 10.1111/jcmm.17073. Online ahead of print. ABSTRACT This study explored the role played by combined ICA and bone...
Doctor, Do You Know Red Yeast Rice?
Praxis (Bern 1994). 2021;110(4):207-220. doi: 10.1024/1661-8157/a003617. ABSTRACT Doctor, Do You Know Red Yeast Rice? Abstract. We present cases of patients with high total cholesterol who...
Hypolipaemic nutraceutics: red yeast rice and Armolipid, berberine and bergamot
Ann Agric Environ Med. 2021 Mar 18;28(1):81-88. doi: 10.26444/aaem/130629. Epub 2020 Dec 2. ABSTRACT INTRODUCTION: Increased serum cholesterol levels constitute one of the main risk...
A Combination of Lactoplantibacillus plantarum Strains CECT7527, CECT7528, and CECT7529 Plus Monacolin K Reduces Blood Cholesterol: Results from a Randomized, Double-Blind, Placebo-Controlled Study
Nutrients. 2021 Apr 6;13(4):1206. doi: 10.3390/nu13041206. ABSTRACT BACKGROUND: Dietary supplements have been proposed to help manage blood cholesterol, including red yeast rice (RYR) extracts, plant...
Lipid Profile and Vascular Remodelling in Young Dyslipidemic Subjects Treated with Nutraceuticals Derived from Red Yeast Rice
Cardiovasc Ther. 2021 Apr 22;2021:5546800. doi: 10.1155/2021/5546800. eCollection 2021. ABSTRACT BACKGROUND AND AIMS: A relevant role is emerging for functional foods in cardiovascular prevention. The...
Impact of nutraceuticals on markers of systemic inflammation: Potential relevance to cardiovascular diseases – A position paper from the International Lipid Expert Panel (ILEP)
Prog Cardiovasc Dis. 2021 Jul-Aug;67:40-52. doi: 10.1016/j.pcad.2021.06.010. Epub 2021 Jun 27. ABSTRACT Inflammation is a marker of arterial disease stemming from cholesterol-dependent to -independent molecular...
Postmarketing nutrivigilance safety profile: a line of dietary food supplements containing red yeast rice for dyslipidemia
Arch Med Sci. 2021 Mar 4;17(4):856-863. doi: 10.5114/aoms/133716. eCollection 2021. ABSTRACT INTRODUCTION: In the absence of a European standardized postmarketing food supplement surveillance system (nutrivigilance),...
Nutraceuticals in the Management of Dyslipidemia: Which, When, and for Whom? Could Nutraceuticals Help Low-Risk Individuals with Non-optimal Lipid Levels?
Curr Atheroscler Rep. 2021 Aug 4;23(10):57. doi: 10.1007/s11883-021-00955-y. ABSTRACT PURPOSE OF REVIEW: The aim of this review is to summarize the available clinical efficacy and...
Acute and Long Term Effects of a Nutraceutical Combination on Lipid Profile, Glucose Metabolism and Vascular Function in Patients with Dyslipidaemia with and Without Cigarette Smoking
High Blood Press Cardiovasc Prev. 2021 Sep;28(5):483-491. doi: 10.1007/s40292-021-00468-4. Epub 2021 Sep 13. ABSTRACT INTRODUCTION: Lifestyle changes present a fundamental role in cardiovascular prevention. Nutraceuticals...
Nutraceutical Combinations in Hypercholesterolemia: Evidence from Randomized, Placebo-Controlled Clinical Trials
Nutrients. 2021 Sep 8;13(9):3128. doi: 10.3390/nu13093128. ABSTRACT There is an increasing number of nutraceutical combinations (NCs) on the market for hypercholesterolemia, although clinical trials to...
Low dose red yeast rice with monacolin K lowers LDL cholesterol and blood pressure in Japanese with mild dyslipidemia: A multicenter, randomized trial
Asia Pac J Clin Nutr. 2021 Sep;30(3):424-435. doi: 10.6133/apjcn.202109_30(3).0009. ABSTRACT BACKGROUND AND OBJECTIVES: Red yeast rice contains monacolin K, an inhibitor of cholesterol synthesis, and...