Natural sesame oil is superior to pre-digested lipid formulations and purified triglycerides in promoting the intestinal lymphatic transport and systemic bioavailability of cannabidiol
Eur J Pharm Biopharm. 2021 May;162:43-49. doi: 10.1016/j.ejpb.2021.02.013. Epub 2021 Mar 5. ABSTRACT Lipid-based formulations play a significant role in oral delivery of lipophilic drugs....
In vitro dissolution behaviour and absorption in humans of a novel mixed l-lysine salt formulation of EPA and DHA
Prostaglandins Leukot Essent Fatty Acids. 2021 Jan;164:102232. doi: 10.1016/j.plefa.2020.102232. Epub 2020 Dec 19. ABSTRACT INTRODUCTION: Supplements with eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are...
Salmon food matrix influences digestion and bioavailability of long-chain omega-3 polyunsaturated fatty acids
Food Funct. 2021 Jul 21;12(14):6588-6602. doi: 10.1039/d1fo00475a. Epub 2021 Jun 8. ABSTRACT The natural structure of whole food plays an important role in the physiological...
Absorption, Distribution, Metabolism, and Excretion of the Main Olive Tree Phenols and Polyphenols: A Literature Review
J Agric Food Chem. 2021 May 12;69(18):5281-5296. doi: 10.1021/acs.jafc.1c00737. Epub 2021 Apr 28. ABSTRACT The effects of olive tree (poly)phenols (OPs) are largely dependent upon...
Olive oil and oleic acid-based self nano-emulsifying formulation of omega-3-fatty acids with improved strength, stability, and therapeutics
J Microencapsul. 2021 Aug;38(5):298-313. doi: 10.1080/02652048.2021.1914760. Epub 2021 May 17. ABSTRACT AIM: To develop, characterise, and optimise SNEDDS formulation to enhance organoleptics, bioavailability, physical &...
Impact of excipient emulsions made from different types of oils on the bioavailability and metabolism of curcumin in gastrointestinal tract
Food Chem. 2022 Feb 15;370:130980. doi: 10.1016/j.foodchem.2021.130980. Epub 2021 Aug 30. ABSTRACT Low bioavailability currently limits the potential of curcumin as a health-promoting dietary compound....
Maximizing the Oral Bioavailability of Poorly Water-Soluble Drugs Using Novel Oil-Like Materials in Lipid-Based Formulations
Mol Pharm. 2021 Sep 6;18(9):3281-3289. doi: 10.1021/acs.molpharmaceut.1c00197. Epub 2021 Aug 5. ABSTRACT Lipid-based formulations, such as self-microemulsifying drug-delivery systems (SMEDDSs), are promising tools for the...
Medium Chain Triglycerides Promote the Uptake of β-Carotene in O/W Emulsions via Intestinal Transporter SR-B1 in Caco-2 Cells
J Agric Food Chem. 2022 Aug 3;70(30):9377-9387. doi: 10.1021/acs.jafc.2c02660. Epub 2022 Jul 21. ABSTRACT This study aimed to elucidate the impacts of carrier oil types...
Effect of Gum Acacia on the Intestinal Bioavailability of n-3 Polyunsaturated Fatty Acids in Rats
Biomolecules. 2022 Jul 12;12(7):975. doi: 10.3390/biom12070975. ABSTRACT Lipid emulsification is a technique that is being explored for improving the bioavailability of omega 3 (n-3) long...
Supplemental Vitamin D and Incident Fractures in Midlife and Older Adults
N Engl J Med. 2022 Jul 28;387(4):299-309. doi: 10.1056/NEJMoa2202106. ABSTRACT BACKGROUND: Vitamin D supplements are widely recommended for bone health in the general population, but...
Norepinephrine Inhibits Lipopolysaccharide-Stimulated TNF-α but Not Oxylipin Induction in n-3/n-6 PUFA-Enriched Cultures of Circumventricular Organs
Int J Mol Sci. 2022 Aug 6;23(15):8745. doi: 10.3390/ijms23158745. ABSTRACT Sensory circumventricular organs (sCVOs) are pivotal brain structures involved in immune-to-brain communication with a leaky...
Differential Effect of Dietary Supplementation with a Soybean Oil Enriched in Oleic Acid versus Linoleic Acid on Plasma Lipids and Atherosclerosis in LDLR-Deficient Mice
Int J Mol Sci. 2022 Jul 29;23(15):8385. doi: 10.3390/ijms23158385. ABSTRACT Both monounsaturated fatty acids (MUFAs) and polyunsaturated fatty acids (PUFAs) play important roles in lipid...
Long-Term Adherence to a Mediterranean Diet 1-Year after Completion of the MedLey Study
Nutrients. 2022 Jul 28;14(15):3098. doi: 10.3390/nu14153098. ABSTRACT Mediterranean populations enjoy the health benefits of a Mediterranean diet (MedDiet), but is it feasible to implement such...
Docosahexaenoic Acid as the Bidirectional Biomarker of Dietary and Metabolic Risk Patterns in Chinese Children: A Comparison with Plasma and Erythrocyte
Nutrients. 2022 Jul 28;14(15):3095. doi: 10.3390/nu14153095. ABSTRACT OBJECTIVE: The present study aims to measure docosahexaenoic acid (DHA) in both the plasma and erythrocyte of a...
Biological Role of Nutrients, Food and Dietary Patterns in the Prevention and Clinical Management of Major Depressive Disorder
Nutrients. 2022 Jul 28;14(15):3099. doi: 10.3390/nu14153099. ABSTRACT Major Depressive Disorder (MDD) is a growing disabling condition affecting around 280 million people worldwide. This complex entity...