Minimal food effect for eicosapentaenoic acid and docosahexaenoic acid bioavailability from omega-3-acid ethyl esters with an Advanced Lipid TechnologiesTM (ALT®)-based formulation
J Clin Lipidol. 2017 Mar-Apr;11(2):394-405. doi: 10.1016/j.jacl.2017.01.017. Epub 2017 Feb 9. ABSTRACT BACKGROUND: The absorption of eicosapentaenoic acid (EPA; 20:5n-3) and docosahexaenoic acid (DHA; 22:6n-3)...
A novel self-micro-emulsifying delivery system (SMEDS) formulation significantly improves the fasting absorption of EPA and DHA from a single dose of an omega-3 ethyl ester concentrate
Lipids Health Dis. 2017 Oct 16;16(1):204. doi: 10.1186/s12944-017-0589-0. ABSTRACT BACKGROUND: Absorption of EPA and DHA from Omega-3-acid ethyl ester (EE) concentrate supplements occurs most efficiently...
Changes in Bioavailability of Omega-3 (DHA) through Alpha-Tocopheryl Phosphate Mixture (TPM) after Oral Administration in Rats
Nutrients. 2017 Sep 20;9(9):1042. doi: 10.3390/nu9091042. ABSTRACT Benefits of Omega-3 Docosahexaenoic acid (DHA) supplements are hindered by their poor solubility and bioavailability. This study investigated...
Relative levels of dietary EPA and DHA impact gastric oxidation and essential fatty acid uptake
J Nutr Biochem. 2018 May;55:68-75. doi: 10.1016/j.jnutbio.2017.11.007. Epub 2017 Dec 10. ABSTRACT Previous research showed that increasing the proportion of docosahexaenoic acid (DHA) in marine...
Oral Delivery of Highly Lipophilic, Poorly Water-Soluble Drugs: Self-Emulsifying Drug Delivery Systems to Improve Oral Absorption and Enable High-Dose Toxicology Studies of a Cholesteryl Ester Transfer Protein Inhibitor in Preclinical Species
J Pharm Sci. 2018 May;107(5):1352-1360. doi: 10.1016/j.xphs.2018.01.003. Epub 2018 Jan 6. ABSTRACT BMS-A is an inhibitor of cholesteryl ester transfer protein and is a highly...
Correlating in Vitro Solubilization and Supersaturation Profiles with in Vivo Exposure for Lipid Based Formulations of the CETP Inhibitor CP-532,623
Mol Pharm. 2017 Dec 4;14(12):4525-4538. doi: 10.1021/acs.molpharmaceut.7b00660. Epub 2017 Nov 9. ABSTRACT Lipid based formulations (LBFs) are a promising formulation strategy for many poorly water-soluble...
Absorption rate of krill oil and fish oil in blood and brain of rats
Lipids Health Dis. 2018 Jul 18;17(1):162. doi: 10.1186/s12944-018-0812-7. ABSTRACT BACKGROUND: Krill (Euphausia superba) is a small marine crustacean with a lipid content. The mechanism of...
Supersaturable Self-Emulsifying Drug Delivery System of Krill Oil with Improved Oral Absorption and Hypotriglyceridemic Function
J Agric Food Chem. 2018 May 30;66(21):5352-5358. doi: 10.1021/acs.jafc.8b00693. Epub 2018 May 21. ABSTRACT This study aimed to develop a supersaturable self-emulsifying drug delivery system...
Bioavailability and Safety of Nutrients from the Microalgae Chlorella vulgaris, Nannochloropsis oceanica and Phaeodactylum tricornutum in C57BL/6 Mice
Nutrients. 2018 Jul 26;10(8):965. doi: 10.3390/nu10080965. ABSTRACT Microalgae are rich in macronutrients and therefore, they have been proposed as a potential future food source preserving...
Intrinsic and Extrinsic Factors Impacting Absorption, Metabolism, and Health Effects of Dietary Carotenoids
Adv Nutr. 2018 Jul 1;9(4):465-492. doi: 10.1093/advances/nmy025. ABSTRACT Carotenoids are orange, yellow, and red lipophilic pigments present in many fruit and vegetables, as well as...
Effects of a Self-micro-emulsifying Delivery System Formulation Versus a Standard ω-3 Acid Ethyl Ester Product on the Bioavailability of Eicosapentaenoic Acid and Docosahexaenoic Acid: A Study in Healthy Men and Women in a Fasted State
Clin Ther. 2018 Dec;40(12):2065-2076. doi: 10.1016/j.clinthera.2018.10.014. Epub 2018 Nov 16. ABSTRACT PURPOSE: Intakes of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are associated with several...
Effect of linolenic acid on bioavailability of cadmium in eutrophic water
Wei Sheng Yan Jiu. 2018 Jul;47(4):644-661. ABSTRACT OBJECTIVE: To investigate the bioavailability of heavy metal cadmium on planktonic algae under the condition of containing linolenic...
Bioavailability of docosahexaenoic acid 22:6(n-3) from enantiopure triacylglycerols and their regioisomeric counterpart in rats
Food Chem. 2019 Jun 15;283:381-389. doi: 10.1016/j.foodchem.2018.12.130. Epub 2019 Jan 14. ABSTRACT Lack of synthetic enantiospecific triacylglycerols (TAGs) has hindered our understanding of the impact...
Strategies to improve bioavailability of omega-3 fatty acids from ethyl ester concentrates
Curr Opin Clin Nutr Metab Care. 2019 Mar;22(2):116-123. doi: 10.1097/MCO.0000000000000537. ABSTRACT PURPOSE OF REVIEW: To describe recent strategies that have been developed to enhance absorption...
In vitro lipolysis and lymphatic absorption of n-3 long-chain PUFA in the rat: influence of the molecular lipid species as carrier
Br J Nutr. 2019 Sep 28;122(6):639-647. doi: 10.1017/S0007114519001491. ABSTRACT The aim of this work was to study the bioavailability of fatty acids (FA), focusing on...