Screening and characterization of a GH78 alpha-l-rhamnosidase from Aspergillus terreus and its application in the bioconversion of icariin to icaritin with recombinant beta-glucosidase
Enzyme Microb Technol. 2021 Nov 10;153:109940. doi: 10.1016/j.enzmictec.2021.109940. Online ahead of print. ABSTRACT In this study, a GH78 α-L-rhamnosidase AtRha from Aspergillus terreus CCF3059 was...
Effect of the icariin on endothelial microparticles, endothelial progenitor cells, platelets, and erectile function in spontaneously hypertensive rats
Andrology. 2021 Nov 14. doi: 10.1111/andr.13127. Online ahead of print. ABSTRACT OBJECTIVES: To investigate the effect of icariin on endothelial microparticles, endothelial progenitor cells, platelets,...
The Anti-Inflammatory Effect of a Combination of Five Compounds From Five Chinese Herbal Medicines Used in the Treatment of COPD
Front Pharmacol. 2021 Oct 27;12:709702. doi: 10.3389/fphar.2021.709702. eCollection 2021. ABSTRACT Effective compound combination (ECC; i.e, 20-S-ginsenoside Rh1, astragaloside, icariin, nobiletin, and paeonol), derived from Chinese...
Icariin accelerates cartilage defect repair by promoting chondrogenic differentiation of BMSCs under conditions of oxygen-glucose deprivation
J Cell Mol Med. 2021 Dec 3. doi: 10.1111/jcmm.17073. Online ahead of print. ABSTRACT This study explored the role played by combined ICA and bone...
3D printing of alginate dialdehyde-gelatin (ADA-GEL) hydrogels incorporating phytotherapeutic icariin loaded mesoporous SiO(2)-CaO nanoparticles for bone tissue engineering
Mater Sci Eng C Mater Biol Appl. 2021 Dec;131:112470. doi: 10.1016/j.msec.2021.112470. Epub 2021 Oct 2. ABSTRACT 3D printing enables a better control over the microstructure...
Icariin activates autophagy to trigger TGFbeta1 upregulation and promote angiogenesis in EA.hy926 human vascular endothelial cells
Bioengineered. 2021 Nov 30. doi: 10.1080/21655979.2021.2011637. Online ahead of print. ABSTRACT Angiogenesis plays an important role in tissue development and repair, and how to regulate...
Icariin Protects H9c2 Rat Cardiomyoblasts from Doxorubicin-Induced Cardiotoxicity: Role of Caveolin-1 Upregulation and Enhanced Autophagic Response
Nutrients. 2021 Nov 14;13(11):4070. doi: 10.3390/nu13114070. ABSTRACT Doxorubicin (Doxo) is a widely used antineoplastic drug which often induces cardiomyopathy, leading to congestive heart failure through...
Bioactive Flavonoids Icaritin and Icariin Protect against Cerebral Ischemia-Reperfusion-Associated Apoptosis and Extracellular Matrix Accumulation in an Ischemic Stroke Mouse Model
Biomedicines. 2021 Nov 19;9(11):1719. doi: 10.3390/biomedicines9111719. ABSTRACT Stroke, which is the second leading cause of mortality in the world, is urgently needed to explore the...
Icariin Alleviates Wear Particle-Induced Periprosthetic Osteolysis via Down-Regulation of the Estrogen Receptor alpha-mediated NF-kappaB Signaling Pathway in Macrophages
Front Pharmacol. 2021 Nov 3;12:746391. doi: 10.3389/fphar.2021.746391. eCollection 2021. ABSTRACT Periprosthetic osteolysis is one of the major long-term complications following total joint replacement. Its cause...
Effective-compound combination inhibits the M2-like polarization of macrophages and attenuates the development of pulmonary fibrosis by increasing autophagy through mTOR signaling
Int Immunopharmacol. 2021 Nov 17:108360. doi: 10.1016/j.intimp.2021.108360. Online ahead of print. ABSTRACT BACKGROUND AND PURPOSE: The M2 polarization of macrophages substantially contributes to the progression...