Intergenerational trauma transmission is associated with brain metabotranscriptome remodeling and mitochondrial dysfunction
Commun Biol. 2021 Jun 24;4(1):783. doi: 10.1038/s42003-021-02255-2. ABSTRACT Intergenerational trauma increases lifetime susceptibility to depression and other psychiatric disorders. Whether intergenerational trauma transmission is a...
Cerebellar mitochondrial dysfunction and concomitant multi-system fatty acid oxidation defects are sufficient to discriminate PTSD-like and resilient male mice
Brain Behav Immun Health. 2020 Jul 8;6:100104. doi: 10.1016/j.bbih.2020.100104. eCollection 2020 Jul. ABSTRACT The impact of trauma on mental health is complex with poorly understood...
Acetyl-L-carnitine in chronic pain: A narrative review
Pharmacol Res. 2021 Nov;173:105874. doi: 10.1016/j.phrs.2021.105874. Epub 2021 Sep 7. ABSTRACT Acetyl-L-carnitine (ALC) is an endogenous molecule that not only plays a role in energy...
Correlation between acute brain injury and brain metabonomics in dichlorvos-poisoned broilers
J Hazard Mater. 2022 Jan 15;422:126849. doi: 10.1016/j.jhazmat.2021.126849. Epub 2021 Aug 8. ABSTRACT Dichlorvos (DDVP) is an insecticide with neurotoxicity that is widely used in...
Quantification of Differential Metabolites in Dried Blood Spots Using Second-Tier Testing for SCADD/IBDD Disorders Based on Large-Scale Newborn Screening in a Chinese Population
Front Pediatr. 2021 Nov 19;9:757424. doi: 10.3389/fped.2021.757424. eCollection 2021. ABSTRACT Background: Although newborn screening (NBS) for metabolic defects using the marker butyl carnitine (C4) combined...
L-Carnitine and Acetyl-L-Carnitine: Potential Novel Biomarkers for Major Depressive Disorder
Front Psychiatry. 2021 Sep 30;12:671151. doi: 10.3389/fpsyt.2021.671151. eCollection 2021. ABSTRACT The lack of biomarkers greatly limits the diagnosis and treatment of major depressive disorder (MDD)....
Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety Treatments (CANMAT) Taskforce
World J Biol Psychiatry. 2022 Mar 21:1-32. doi: 10.1080/15622975.2021.2013041. Online ahead of print. ABSTRACT OBJECTIVES: The therapeutic use of nutrient-based ‘nutraceuticals’ and plant-based ‘phytoceuticals’ for...
Non-targeted Metabolomics Profiling of Plasma Samples From Patients With Major Depressive Disorder
Front Psychiatry. 2022 Feb 21;12:810302. doi: 10.3389/fpsyt.2021.810302. eCollection 2021. ABSTRACT BACKGROUND: Major depressive disorder (MDD) is a neuropsychiatric disorder caused by multiple factors. Although there...
Acetyl-L-carnitine and/or liposomal co-enzyme Q10 prevent propionic acid-induced neurotoxicity by modulating oxidative tissue injury, inflammation, and ALDH1A1-RA-RARα signaling in rats
Biomed Pharmacother. 2022 Jul 1;153:113360. doi: 10.1016/j.biopha.2022.113360. Online ahead of print. ABSTRACT Propionic acid (PPA) is a short-chain fatty acid produced endogenously by gut microbiota...
Acute Lymphoblastic Leukemia in Combined Methylmalonic Acidemia and Homocysteinemia (cblC Type): A Case Report and Literature Review
Front Genet. 2022 Apr 14;13:856552. doi: 10.3389/fgene.2022.856552. eCollection 2022. ABSTRACT Background: Methylmalonic acidemia (MMA) can display many clinical manifestations, among which acute lymphoblastic leukemia (ALL)...
Acetyl-L-Carnitine Exerts Neuroprotective and Anticonvulsant Effect in Kainate Murine Model of Temporal Lobe Epilepsy
J Mol Neurosci. 2022 Jun;72(6):1224-1233. doi: 10.1007/s12031-022-01999-8. Epub 2022 Mar 23. ABSTRACT The most well-known type of focal epilepsy that is resistant to existing treatments...
Clinical Evidence of Acetyl-L-Carnitine Efficacy in the Treatment of Acute Ischemic Stroke: A Pilot Clinical Trial
Oxid Med Cell Longev. 2022 Jul 29;2022:2493053. doi: 10.1155/2022/2493053. eCollection 2022. ABSTRACT BACKGROUND: This study was undertaken to evaluate the influence of oral Acetyl-L-carnitine (ALC)...
Acetyl-L-carnitine attenuates Poly I: C- induced sickness behavior in mice
Biosci Biotechnol Biochem. 2022 Aug 9:zbac132. doi: 10.1093/bbb/zbac132. Online ahead of print. ABSTRACT Fatigue is accompanied by a decrease in physical activity or malaise, and...
Calanus Oil Supplementation Does Not Further Improve Short-Term Memory or Brain-Derived Neurotrophic Factor in Older Women Who Underwent Exercise Training
Clin Interv Aging. 2022 Aug 13;17:1227-1236. doi: 10.2147/CIA.S368079. eCollection 2022. ABSTRACT PURPOSE: In our study, we examined changes in short-term episodic memory and brain-derived neurotrophic...
Influence of Ingestion of Eicosapentaenoic Acid-Rich Fish Oil on Oxidative Stress at the Menstrual Phase: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial
Womens Health Rep (New Rochelle). 2022 Jul 13;3(1):643-651. doi: 10.1089/whr.2022.0003. eCollection 2022. ABSTRACT BACKGROUND: This study examines the effect of the supplements on the redox...