Behavioral, Biochemical and Histopathological effects of Standardised Pomegranate extract with Vinpocetine, Propolis or Cocoa in a rat model of Parkinson’s disease
Exp Aging Res. 2021 Aug 12:1-20. doi: 10.1080/0361073X.2021.1959823. Online ahead of print. ABSTRACT INTRODUCTION: Parkinsonism is a neurodegenerative disorder. Pomegranate (POM) has been previously shown...
Intake of Products Containing Anthocyanins, Flavanols, and Flavanones, and Cognitive Function: A Narrative Review
Front Aging Neurosci. 2021 Sep 3;13:640381. doi: 10.3389/fnagi.2021.640381. eCollection 2021. ABSTRACT The purpose of this review is to examine human research studies published within the...
Consumption of 85% cocoa dark chocolate improves mood in association with gut microbial changes in healthy adults: a randomized controlled trial
J Nutr Biochem. 2022 Jan;99:108854. doi: 10.1016/j.jnutbio.2021.108854. Epub 2021 Sep 14. ABSTRACT Dark chocolate has long been recognized for its mood-altering properties; however, the evidence...
The role of nutraceuticals in prevention and treatment of hypertension: An updated review of the literature
Food Res Int. 2020 Feb;128:108749. doi: 10.1016/j.foodres.2019.108749. Epub 2019 Nov 7. ABSTRACT Hypertension (HTN) is a worldwide epidemic in both developed and developing countries. It...
Chocolate, “Food of the Gods”: History, Science, and Human Health
Int J Environ Res Public Health. 2019 Dec 6;16(24):4960. doi: 10.3390/ijerph16244960. ABSTRACT Chocolate is well known for its fine flavor, and its history began in...
Chronic and acute effects of cocoa products intake on arterial stiffness and platelet count and function: A systematic review and dose-response Meta-analysis of randomized clinical trials
Crit Rev Food Sci Nutr. 2021;61(3):357-379. doi: 10.1080/10408398.2020.1733484. Epub 2020 Mar 4. ABSTRACT The findings of trials investigating the effect of cocoa products consumption on...
Acute (-)-Epicatechin Consumption: Effects on Local Vasodilation Following Resistance Exercise and High-Intensity Exercise Performance
Sports (Basel). 2020 Feb 15;8(2):22. doi: 10.3390/sports8020022. ABSTRACT (-)-Epicatechin is a polyphenol previously shown to enhance vascular health. The purposes of the current studies were...
Effects of Cocoa-Rich Chocolate on Blood Pressure, Cardiovascular Risk Factors, and Arterial Stiffness in Postmenopausal Women: A Randomized Clinical Trial
Nutrients. 2020 Jun 12;12(6):1758. doi: 10.3390/nu12061758. ABSTRACT This study aimed to evaluate the effects of the intake of 10 g of cocoa-rich chocolate on blood...
Chronic Consumption of Bovine Dairy Milk Attenuates Dietary Saturated Fatty Acid-Induced Blood-Brain Barrier Dysfunction
Front Nutr. 2020 May 6;7:58. doi: 10.3389/fnut.2020.00058. eCollection 2020. ABSTRACT Ingestion of Western-diets enriched in long chain saturated fatty acids (LCSFA) are associated with increased...
Cocoa Flavanols Protect Human Endothelial Cells from Oxidative Stress
Plant Foods Hum Nutr. 2020 Jun;75(2):161-168. doi: 10.1007/s11130-020-00807-1. ABSTRACT Oxidative stress may cause functional disorders of vascular endothelia which can lead to endothelial apoptosis and...
Dietary flavanols improve cerebral cortical oxygenation and cognition in healthy adults
Sci Rep. 2020 Nov 24;10(1):19409. doi: 10.1038/s41598-020-76160-9. ABSTRACT Cocoa flavanols protect humans against vascular disease, as evidenced by improvements in peripheral endothelial function, likely through...
Preventive effect of cocoa flavanols against glucotoxicity-induced vascular inflammation in the arteria of diabetic rats and on the inflammatory process in TNF-alpha-stimulated endothelial cells
Food Chem Toxicol. 2020 Dec;146:111824. doi: 10.1016/j.fct.2020.111824. Epub 2020 Oct 21. ABSTRACT Hyperglycaemia induces a vascular inflammatory process that is a critical event in cardiovascular...
Changes in the Composition of Methylxanthines, Polyphenols, and Volatiles and Sensory Profiles of Cocoa Beans from the Sul 1 Genotype Affected by Fermentation
J Agric Food Chem. 2020 Aug 12;68(32):8658-8675. doi: 10.1021/acs.jafc.0c02909. Epub 2020 Jul 29. ABSTRACT The Sul 1 cacao (Theobroma cacao) genotype has become more popular...
Acute Effects of Cocoa Flavanols on Blood Pressure and Peripheral Vascular Reactivity in Type 2 Diabetes Mellitus and Essential Hypertension: A Protocol for an Acute, Randomized, Double-Blinded, Placebo-Controlled Cross-Over Trial
Front Cardiovasc Med. 2021 Mar 15;8:602086. doi: 10.3389/fcvm.2021.602086. eCollection 2021. ABSTRACT Introduction: Patients with type 2 diabetes mellitus are at high risk to develop vascular...
Cocoa Flavanols Improve Vascular Responses to Acute Mental Stress in Young Healthy Adults
Nutrients. 2021 Mar 27;13(4):1103. doi: 10.3390/nu13041103. ABSTRACT Mental stress has been shown to induce cardiovascular events, likely due to its negative impact on vascular function....