Associations of alcohol and cannabis use with change in posttraumatic stress disorder and depression symptoms over time in recently trauma-exposed individuals
Psychol Med. 2023 Jun 13:1-12. doi: 10.1017/S0033291723001642. Online ahead of print. ABSTRACT BACKGROUND: Several hypotheses may explain the association between substance use, posttraumatic stress disorder...
Independent contribution of polygenic risk for schizophrenia and cannabis use in predicting psychotic-like experiences in young adulthood: testing gene × environment moderation and mediation
Psychol Med. 2023 Apr;53(5):1759-1769. doi: 10.1017/S0033291721003378. Epub 2021 Sep 23. ABSTRACT BACKGROUND: It has not yet been determined if the commonly reported cannabis-psychosis association is...
Non-Psychoactive Cannabinoid Modulation of Nociception and Inflammation Associated with a Rat Model of Pulpitis
Biomolecules. 2023 May 16;13(5):846. doi: 10.3390/biom13050846. ABSTRACT Despite advancements in dental pain management, one of the most common reasons for emergency dental care is orofacial...
Isolation of Biologically Active Compounds from Cannabis sativa L. Inflorescences by Using Different Extraction Solvents and Evaluation of Antimicrobial Activity
Antioxidants (Basel). 2023 Apr 25;12(5):998. doi: 10.3390/antiox12050998. ABSTRACT Hemp inflorescences are a source of vital compounds, including phytocannabinoids and other biologically active compounds. Various methods...
Role of omega-3 and omega-6 endocannabinoids in cardiopulmonary pharmacology
Adv Pharmacol. 2023;97:375-422. doi: 10.1016/bs.apha.2023.02.003. Epub 2023 Mar 28. ABSTRACT Endocannabinoids are derived from dietary omega-3 and omega-6 fatty acids and play an important role...
Bioactivity of the cannabigerol cannabinoid and its analogues – the role of 3-dimensional conformation
Org Biomol Chem. 2023 Jun 7;21(22):4683-4693. doi: 10.1039/d3ob00383c. ABSTRACT Cannabinoids are naturally occurring bioactive compounds with the potential to help treat chronic illnesses including epilepsy,...
Development, Characterization and Evidence of Anti-Endometriotic Activity of Phytocannabinoid-Rich Nanoemulsions
Int J Pharm. 2023 May 15:123049. doi: 10.1016/j.ijpharm.2023.123049. Online ahead of print. ABSTRACT During the last decades, the cannabinoid research for therapeutic purposes has been...
Cannabis Is Not Doping
Cannabis Cannabinoid Res. 2023 Jun 6. doi: 10.1089/can.2023.0012. Online ahead of print. ABSTRACT The World Anti-Doping Agency (WADA) classifies cannabis, all phytocannabinoids, and synthetics as...
Preparation of poly(methacrylic acid-co-ethylene glycol dimethacrylate)-functionalized magnetic polydopamine nanoparticles for the extraction of six cannabinoids in wastewater followed by UHPLC-MS/MS
Talanta. 2023 May 31;264:124752. doi: 10.1016/j.talanta.2023.124752. Online ahead of print. ABSTRACT Phytocannabinoids and their synthetic analogs (natural and synthetic cannabinoids) are illicit drugs that are...
Beyond Pain Relief: A Review on Cannabidiol Potential in Medical Therapies
Pharmaceuticals (Basel). 2023 Jan 20;16(2):155. doi: 10.3390/ph16020155. ABSTRACT The phytocannabinoid cannabidiol (CBD) is receiving increasing attention due to its pharmacological properties. Although CBD is extracted...
Anti-allodynic and medullary modulatory effects of a single dose of delta-9-tetrahydrocannabinol (THC) in neuropathic rats tolerant to morphine
Prog Neuropsychopharmacol Biol Psychiatry. 2023 May 29:110805. doi: 10.1016/j.pnpbp.2023.110805. Online ahead of print. ABSTRACT Neuropathic pain (NP) is often treated with opioids, the prolonged use...
Cell-autonomous and differential endocannabinoid signaling impacts the development of presynaptic retinal ganglion cell axon connectivity in vivo
Front Synaptic Neurosci. 2023 May 12;15:1176864. doi: 10.3389/fnsyn.2023.1176864. eCollection 2023. ABSTRACT Cannabis exposure during gestation evokes significant molecular modifications to neurodevelopmental programs leading to neurophysiological...
Cannabidiol and Minor Phytocannabinoids: A Preliminary Study to Assess Their Anti-Melanoma, Anti-Melanogenic, and Anti-Tyrosinase Properties
Pharmaceuticals (Basel). 2023 Apr 26;16(5):648. doi: 10.3390/ph16050648. ABSTRACT Currently, there is an increased interest from both scientists and consumers in the application of cannabis/hemp/phytocannabinoids in...
Cannabinoid and Opioid Receptor Affinity and Modulation of Cancer-Related Signaling Pathways of Machaeriols and Machaeridiols from Machaerium Pers
Molecules. 2023 May 18;28(10):4162. doi: 10.3390/molecules28104162. ABSTRACT Machaeriols and machaeridiols are unique hexahydrodibenzopyran-type aralkyl phytocannabinoids isolated from Machaerium Pers. Earlier studies of machaeriol A (1)...
The current role of cannabis and cannabinoids in health: A comprehensive review of their therapeutic potential
Life Sci. 2023 Jun 6:121838. doi: 10.1016/j.lfs.2023.121838. Online ahead of print. ABSTRACT There has been an increased interest of the scientific community in cannabis and...