High-Throughput Sequencing and Bioinformatics analysis reveals the neurogenesis key targets of Curcumin action in mouse brain with MCAO
Comb Chem High Throughput Screen. 2022 Aug 3. doi: 10.2174/1386207325666220803090112. Online ahead of print. ABSTRACT BACKGROUND: Experimental studies have shown that Curcumin exerts neuroprotective effects...
Antioxidant and Neuroprotective Effects of L-arginine Administration After Traumatic Brain Injury and Hemorrhagic Shock in Rats
Turk Neurosurg. 2022 Feb 2. doi: 10.5137/1019-5149.JTN.35263-21.2. Online ahead of print. ABSTRACT AIM: The aim of the current study was to investigate the effect of...
Natural Antioxidant Compounds as Potential Pharmaceutical Tools against Neurodegenerative Diseases
ACS Omega. 2022 Jul 19;7(30):25974-25990. doi: 10.1021/acsomega.2c03291. eCollection 2022 Aug 2. ABSTRACT Natural antioxidants are a very large diversified family of molecules classified by activity...
Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism
Front Immunol. 2022 Jul 22;13:943321. doi: 10.3389/fimmu.2022.943321. eCollection 2022. ABSTRACT Quercetin, a naturally non-toxic flavonoid within the safe dose range with antioxidant, anti-apoptotic and anti-inflammatory...
Protective Effect of Curcuma Extract in an Ex Vivo Model of Retinal Degeneration via Antioxidant Activity and Targeting the SUMOylation
Oxid Med Cell Longev. 2022 Jul 29;2022:8923615. doi: 10.1155/2022/8923615. eCollection 2022. ABSTRACT Retinal degeneration is the major and principal cause behind many incurable blindness diseases....
An update on molecular mechanisms of curcumin effect on diabetes
J Food Biochem. 2022 Aug 9:e14358. doi: 10.1111/jfbc.14358. Online ahead of print. ABSTRACT Owing to its prevalent nature, diabetes mellitus has become one of the...
Expanding Arsenal against Neurodegenerative Diseases using Quercetin based Nanoformulations: Breakthroughs and Bottlenecks
Curr Neuropharmacol. 2022 Aug 10. doi: 10.2174/1570159X20666220810105421. Online ahead of print. ABSTRACT Quercetin (Qu), a dietary flavonoid, is obtained from many fruits and vegetables such...
Therapeutic Potential of Quercetin and its Derivatives in Epilepsy: Evidence from Preclinical Studies
Neuromolecular Med. 2022 Aug 11. doi: 10.1007/s12017-022-08724-z. Online ahead of print. ABSTRACT Quercetin is a polyphenolic bioactive compound highly enriched in dietary fruits, vegetables, nuts,...
Expanding Arsenal against Neurodegenerative Diseases using Quercetin based Nanoformulations: Breakthroughs and Bottlenecks
Curr Neuropharmacol. 2022 Aug 10. doi: 10.2174/1570159X20666220810105421. Online ahead of print. ABSTRACT Quercetin (Qu), a dietary flavonoid, is obtained from many fruits and vegetables such...
Advances on nanoformulation approaches for delivering plant-derived antioxidants: A case of quercetin
Int J Pharm. 2022 Aug 8:122093. doi: 10.1016/j.ijpharm.2022.122093. Online ahead of print. ABSTRACT Oxidative stress has been implicated in tumorigenic, cardiovascular, neuro-, and age-related degenerative...
Targeting Oxidative Stress Mechanisms to Treat Alzheimer’s and Parkinson’s Disease: A Critical Review
Oxid Med Cell Longev. 2022 Jul 31;2022:7934442. doi: 10.1155/2022/7934442. eCollection 2022. ABSTRACT Neurodegenerative disorders such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) are becoming...
Ultrasmall Coordination Polymers for Alleviating ROS-Mediated Inflammatory and Realizing Neuroprotection against Parkinson’s Disease
Research (Wash D C). 2022 Jul 18;2022:9781323. doi: 10.34133/2022/9781323. eCollection 2022. ABSTRACT Parkinson’s disease (PD) is the second most common neurodegenerative disease globally, and there...
Therapeutic Role of Curcumin in Diabetes: An Analysis Based on Bioinformatic Findings
Nutrients. 2022 Aug 8;14(15):3244. doi: 10.3390/nu14153244. ABSTRACT BACKGROUND: Diabetes is an increasingly prevalent global disease caused by the impairment in insulin production or insulin function....
Protective and anti-oxidative effects of curcumin and resveratrol on Aβ-oligomer-induced damage in the SH-SY5Y cell line
J Neurol Sci. 2022 Aug 1;441:120356. doi: 10.1016/j.jns.2022.120356. Online ahead of print. ABSTRACT Alzheimer’s disease (AD) is a degenerative disorder characterized by the loss of...
Mechanisms behind the Fibrillation and Toxicity of Insulin Fibrils on Neuron Cells by Engineered Curcumin Analogs
ACS Chem Neurosci. 2022 Aug 15. doi: 10.1021/acschemneuro.2c00209. Online ahead of print. ABSTRACT Among foods, the use of plant derivatives as promising drugs and/or excipients...