The Effects of Blackcurrant and Berry Extracts on Oxidative Stress in Cultured Cardiomyocytes and Microglial Cells
FASEB J. 2022 May;36 Suppl 1. doi: 10.1096/fasebj.2022.36.S1.R2805. ABSTRACT BACKGROUND: Cardiovascular disease (CVD) is the number one cause of morbidity and mortality for both men...
Screening of Non-Purine Ligands Binding to Adenosine Receptors A1 , A2A , A2B , and A3
FASEB J. 2022 May;36 Suppl 1. doi: 10.1096/fasebj.2022.36.S1.R4816. ABSTRACT Adenosine receptors (ARs) are G-protein coupled receptors (GPCRs) which have been shown to have therapeutic potential....
The Effect of Curcumin on Idiopathic Parkinson Disease: A Clinical and Skin Biopsy Study
J Neuropathol Exp Neurol. 2022 May 13:nlac034. doi: 10.1093/jnen/nlac034. Online ahead of print. ABSTRACT There are currently no standardized therapies for Parkinson disease (PD). Curcumin...
Potential Drug Therapy For Fragile X Tremor/Ataxia Syndrome
FASEB J. 2022 May;36 Suppl 1. doi: 10.1096/fasebj.2022.36.S1.R6346. ABSTRACT Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurological disorder that affects carriers of the alleles...
In-Vitro Antioxidant Assays and Computational Investigation of Phytoconstituents from Theobroma cacao Beans as Inhibitors of Neuro-Modulatory Enzymes
FASEB J. 2022 May;36 Suppl 1. doi: 10.1096/fasebj.2022.36.S1.L7613. ABSTRACT Neurodegenerative disease (ND) is a heterogeneous group of disorders characterized by progressive deterioration of neuronal cells...
The Effects of Berry Extracts on Oxidative Stress in Cultured Cardiomyocytes and Microglial Cells: A Potential Cardioprotective and Neuroprotective Mechanism
Molecules. 2022 Apr 27;27(9):2789. doi: 10.3390/molecules27092789. ABSTRACT Oxidative stress is a key underlying factor in cognitive decline and atherosclerosis. Oxidative stress occurs at the cellular...
Biodegradable Nanoparticles Loaded with Levodopa and Curcumin for Treatment of Parkinson’s Disease
Molecules. 2022 Apr 28;27(9):2811. doi: 10.3390/molecules27092811. ABSTRACT Background: Parkinson’s disease (PD) is the second most common age-related neurodegenerative disorder. Levodopa (L-DOPA) remains the gold-standard drug...
Flavonoids as Potential Anti-Inflammatory Molecules: A Review
Molecules. 2022 May 2;27(9):2901. doi: 10.3390/molecules27092901. ABSTRACT Hydroxylated polyphenols, also called flavonoids, are richly present in vegetables, fruits, cereals, nuts, herbs, seeds, stems, and flowers...
Curcumin attenuates LPS-induced sickness behavior and fever LPS-induced in rats by modulating Nrf2 activity
Neurosci Lett. 2022 May 11:136680. doi: 10.1016/j.neulet.2022.136680. Online ahead of print. ABSTRACT Lipopolysaccharide (LPS) is a potent inducer of inflammation, triggering behavioral changes and fever....
Platelet Activating Factor Receptor Exaggerates Microglia-Mediated Microenvironment by IL10-STAT3 Signaling: A Novel Potential Biomarker and Target for Diagnosis and Treatment of Alzheimer’s Disease
Front Aging Neurosci. 2022 Apr 28;14:856628. doi: 10.3389/fnagi.2022.856628. eCollection 2022. ABSTRACT BACKGROUND: Early diagnosis and effective intervention are the keys to delaying the progression of...
Curcumin Restrains Oxidative Stress of After Intracerebral Hemorrhage in Rat by Activating the Nrf2/HO-1 Pathway
Front Pharmacol. 2022 Apr 27;13:889226. doi: 10.3389/fphar.2022.889226. eCollection 2022. ABSTRACT Intracerebral hemorrhage (ICH), a severe hemorrhagic stroke, induces cerebral oxidative stress and severe secondary neurological...
Curcumin inhibits cerebral ischaemia-reperfusion injury and cell apoptosis in rats through the ERK-CHOP-caspase-11 pathway
Pharm Biol. 2022 Dec;60(1):854-861. doi: 10.1080/13880209.2022.2069271. ABSTRACT CONTEXT: Curcumin has a significant effect on cerebral ischaemia-reperfusion injury (CIRI). However, the underlying mechanism is less studied....
Curcumin: reclaiming the lost ground against cancer resistance
Cancer Drug Resist. 2021 Jun 19;4(2):298-320. doi: 10.20517/cdr.2020.92. eCollection 2021. ABSTRACT Curcumin, a polyphenol, has a wide range of biological properties such as anticancer, antibacterial,...
Quercetin alleviated multi-walled carbon nanotubes-induced neurotoxicity in mice through inhibition of oxidation, inflammation, and pyroptosis
Biomed Pharmacother. 2022 May 20;151:113160. doi: 10.1016/j.biopha.2022.113160. Online ahead of print. ABSTRACT Recently, we reported that quercetin (Que) could alleviate immunotoxicity induced by pristine multi-walled...
The influence of a glucose administration on stress responsivity and memory after a socially evaluated cold pressor test
Psychoneuroendocrinology. 2022 May 16;142:105803. doi: 10.1016/j.psyneuen.2022.105803. Online ahead of print. ABSTRACT The nutritional state of participants prior to stress induction via a laboratory stressor has...