Diabetes Mellitus, Race, and Effects of Omega-3 Fatty Acids on Incidence of Heart Failure Hospitalization
JACC Heart Fail. 2022 Apr;10(4):227-234. doi: 10.1016/j.jchf.2021.12.006. Epub 2022 Mar 9. ABSTRACT OBJECTIVES: The primary aim was to evaluate whether prevalent type 2 diabetes (T2D)...
The Influence of Select Medications on Prospective Hemorrhage Risk in Patients with Spinal or Cerebral Cavernous Malformations
World Neurosurg. 2022 Mar 29:S1878-8750(22)00395-3. doi: 10.1016/j.wneu.2022.03.101. Online ahead of print. ABSTRACT BACKGROUND: Effects of select medication on hemorrhage risk in patients with cerebral or...
Integrated gut microbiome and metabolome analyses reveals an inconsistent dose effect of a tuna oil with more higher docosahexaenoic acid content on intestinal dysbiosis and metabolic disorders in high-fat diet-fed mice
J Sci Food Agric. 2022 Apr 3. doi: 10.1002/jsfa.11908. Online ahead of print. ABSTRACT BACKGROUND: The health benefits of tuna oil, which is different from...
Icariin and its metabolites as potential protective phytochemicals against cardiovascular disease: From effects to molecular mechanisms
Biomed Pharmacother. 2022 Mar;147:112642. doi: 10.1016/j.biopha.2022.112642. Epub 2022 Jan 21. ABSTRACT Cardiovascular disease (CVD) is the leading cause of morbidity and mortality among all types...
Icariin attenuates cyclophosphamide-induced cystitis via down-regulation of NF-B and up-regulation of Nrf-2/HO-1 signaling pathways in mice model
Int Immunopharmacol. 2022 Feb 8;106:108604. doi: 10.1016/j.intimp.2022.108604. Online ahead of print. ABSTRACT Cystitis is a chronic bladder pain associated with frequency and nocturia. In the...
Steroid-Induced Osteonecrosis of the Femoral Head: Novel Insight Into the Roles of Bone Endothelial Cells in Pathogenesis and Treatment
Front Cell Dev Biol. 2021 Nov 30;9:777697. doi: 10.3389/fcell.2021.777697. eCollection 2021. ABSTRACT Steroid-induced osteonecrosis of the femoral head (SONFH) is a disease characterized by the...
Protective effects of icariin on dorsal random skin flap survival: An experimental study
Eur J Pharmacol. 2019 Oct 15;861:172600. doi: 10.1016/j.ejphar.2019.172600. Epub 2019 Aug 8. ABSTRACT This study was performed to examine the protective effects of icariin (ICA)...
Inhibition of airway remodeling and inflammatory response by Icariin in asthma
BMC Complement Altern Med. 2019 Nov 19;19(1):316. doi: 10.1186/s12906-019-2743-x. ABSTRACT BACKGROUND: Icariin (ICA) is the major active ingredient extracted from Chinese herbal medicine Epimedium, which...
Icariin promotes angiogenesis in glucocorticoid-induced osteonecrosis of femoral heads: In vitro and in vivo studies
J Cell Mol Med. 2019 Nov;23(11):7320-7330. doi: 10.1111/jcmm.14589. Epub 2019 Sep 10. ABSTRACT The injury and dysfunction of the femoral head microvascular endothelial cells are...
Icariside II affects hippocampal neuron axon regeneration and improves learning and memory in a chronic cerebral hypoperfusion rat model
Int J Clin Exp Pathol. 2019 Mar 1;12(3):826-834. eCollection 2019. ABSTRACT Chronic cerebral hypoperfusion (CCH) is a basic pathological process that is comorbid with brain...
Sex hormone-like Effects of Icariin on T-cells immune modulation in spontaneously hypertensive rats
J Ethnopharmacol. 2021 Apr 6;269:113717. doi: 10.1016/j.jep.2020.113717. Epub 2020 Dec 24. ABSTRACT ETHNOPHARMACOLOGICAL RELEVANCE: Epimedium brevicornu Maxim as a Chinese herb, is recommended for the...
Preliminary study of icariin indicating prevention of steroid-induced osteonecrosis of femoral head by regulating abnormal expression of miRNA-335 and protecting the functions of bone microvascular endothelial cells in rats
Gene. 2021 Jan 15;766:145128. doi: 10.1016/j.gene.2020.145128. Epub 2020 Sep 7. ABSTRACT BACKGROUND: The pathogenesis of osteonecrosis of the femoral head (ONFH) is unclear. Our previous...
Icariin ameliorates endothelial dysfunction in type 1 diabetic rats by suppressing ER stress via the PPARalpha/Sirt1/AMPKalpha pathway
J Cell Physiol. 2021 Mar;236(3):1889-1902. doi: 10.1002/jcp.29972. Epub 2020 Aug 7. ABSTRACT Icariin (ICA), as a flavonoid glycoside, is associated with the improvement of vascular...
Inhibitory mechanism of icariin against oxidative stress-induced calcification in aortic vascular smooth muscle cells
Zhongguo Zhong Yao Za Zhi. 2021 Sep;46(17):4497-4503. doi: 10.19540/j.cnki.cjcmm.20210603.406. ABSTRACT This study aimed to observe the inhibitory effect of icariin against oxidative stress-induced calcification in...
Essential role of protein kinase C betaI in icariin-mediated protection against atherosclerosis
J Pharm Pharmacol. 2021 Aug 12;73(9):1169-1179. doi: 10.1093/jpp/rgab040. ABSTRACT OBJECTIVES: This study aimed to clarify the superior beneficial effects of icariin on atherosclerosis, as well...