HomeIngredientSynthesis and Characterization of Curcumin Incorporated Multi component Nano-Scaffold with Enhanced Anti-bacterial and Wound Healing Properties

Synthesis and Characterization of Curcumin Incorporated Multi component Nano-Scaffold with Enhanced Anti-bacterial and Wound Healing Properties

April 24, 2022

Curr Drug Deliv. 2022 Apr 14. doi: 10.2174/1567201819666220414092342. Online ahead of print.

ABSTRACT

BACKGROUND: Wound healing is one of the major challenges in chronic diseases, the current treatment options are less effective with undesirable side effects, and are expensive. Extensive research is carried out to develop cost-effective, natural, biodegradable wound dressings that can reduce oxidative stress, inflammation and prevent bacterial infections. Curcumin has a plethora of therapeutic applications; however, its low solubility limits its clinical use.

OBJECTIVE: In this study, curcumin nanoparticles (Cur NP) and curcumin-chitosan nanoparticles (CCNP) were incorporated into the chitosan collagen vanillin scaffold, characterized and investigated their potential wound healing properties.

METHOD: The nano-scaffolds were prepared by freeze-drying method and were characterized using Fourier transform infrared spectroscopy, X-ray diffraction, nanoparticle tracking analysis, and scanning electron microscopy. The drug release, antioxidant, antibacterial, and wound healing properties were assessed by in vitro assays.

RESULTS: Cur nano-scaffolds showed particle size of 195.9 nm and 110.6 nm for Cur NP+VC and CCNP+VC respectively. The curcumin encapsulated in the Cur NP+VC and CC+VC nano-scaffolds showed a release profile of > 60% and an improved antioxidant activity of greater than 80%. The nano-scaffolds were antagonistic against Escherichia coli and Staphylococcus aureus, and likewise enhanced wound healing capacity of 85.62 % and 77.05% was observed in murine cell line.

CONCLUSION: The curcumin nano-scaffold is a biodegradable and effective drug delivery system for topical use that can act as an antioxidant, facilitate wound healing, as well as prevent bacterial infections.

PMID:35430990 | DOI:10.2174/1567201819666220414092342

Tags:,

Related Posts

About The Author

Patrick Blanchard MD

Meet Dr. Blanchard Dr. Blanchard’s medical practice is an embodiment of Integrative health which brings conventional and complementary approaches together in a coordinated way. Conveniently located in sunny Florida and over the internet with ValiseMD’s secure HIPPA compliant telXmed servers. Since 1994, patients with a wide range of challenging medical problems have achieved optimum health using the best of natural medicine, judiciously combined with high-tech innovations. Breakthroughs are often achieved even after patients have consulted mainstream specialists and holistic practitioners. Dr. Blanchard is founder and CEO of ValiseMD, Inc. He is board certified in Family Medicine since 1994 and awarded Fellow of the American Academy of Family Physicians in 2001. He received the ‘Teacher of the Year’ award from the University of Kansas School of Medicine at completion of his residency in Family Medicine. He completed a fellowship at Wake Forest University in the field of vascular neurosonology. He holds a medical patent in the field of Gastroenterology. He holds an unrestricted license to practice medicine and surgery in Florida. He started his medical career as a Emergency Medical Technician, then as a Paramedic and later a Medical Doctor.