Preparation and characterization of nanoemulsions of curcumin and echium oil
Heliyon. 2022 Feb 16;8(2):e08974. doi: 10.1016/j.heliyon.2022.e08974. eCollection 2022 Feb.
ABSTRACT
The search for the plant origin bioactive compounds is increasing over animal origin compounds. Echium oil (EO) contains high amounts of plant based omega-3 fatty acids. Moreover, curcumin addition may increase the release of these omega-3 fatty acids during digestion. The study’s objective is to determine the bioaccessibility of curcumin in simulated intestinal digestion conditions and the release behavior of fatty acids of echium oil from nanoemulsions. We prepared curcumin and EO nanoemulsions with a microfluidizer using two different concentrations of surfactant, Tween 80 (5% and 10%). Emulsion stability tests, antioxidant analysis, in vitro oil release and fatty acid composition assays were conducted. Results showed that curcumin-containing nanoemulsions provide higher radical scavenging activity than the EO nanoemulsions. In addition, in vitro bioaccessibility of curcumin after in vitro simulated intestinal digestion was calculated as 35.5%. Gas chromatography results of the digested nanoemulsions revealed that curcumin addition decreases oleic acid release while increasing stearidonic acid (SDA) release.
PMID:35243093 | PMC:PMC8861391 | DOI:10.1016/j.heliyon.2022.e08974
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About The Author
Patrick Blanchard MD
Meet Dr. Blanchard Dr. Blanchard’s medical practice is an embodiment of Integrative health which brings conventional and complementary approaches together in a coordinated way. Conveniently located in sunny Florida and over the internet with ValiseMD’s secure HIPPA compliant telXmed servers. Since 1994, patients with a wide range of challenging medical problems have achieved optimum health using the best of natural medicine, judiciously combined with high-tech innovations. Breakthroughs are often achieved even after patients have consulted mainstream specialists and holistic practitioners. Dr. Blanchard is founder and CEO of ValiseMD, Inc. He is board certified in Family Medicine since 1994 and awarded Fellow of the American Academy of Family Physicians in 2001. He received the ‘Teacher of the Year’ award from the University of Kansas School of Medicine at completion of his residency in Family Medicine. He completed a fellowship at Wake Forest University in the field of vascular neurosonology. He holds a medical patent in the field of Gastroenterology. He holds an unrestricted license to practice medicine and surgery in Florida. He started his medical career as a Emergency Medical Technician, then as a Paramedic and later a Medical Doctor.